Search Results - "LUEBKE, J. I"

Synapses are lost during aging in the primate prefrontal cortex by Peters, A, Sethares, C, Luebke, J.I

“…Abstract An electron microscopic analysis has been carried out on the effects of age on the numerical density of both excitatory (asymmetric) and inhibitory…”
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Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs by Rocher, A.B., Crimins, J.L., Amatrudo, J.M., Kinson, M.S., Todd-Brown, M.A., Lewis, J., Luebke, J.I.

“…In the rTg4510 mouse model, expression of the mutant human tau variant P301L leads to development of neurofibrillary tangles (NFTs), neuronal death, and memory…”
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Age-related alterations to working memory and to pyramidal neurons in the prefrontal cortex of rhesus monkeys begin in early middle-age and are partially ameliorated by dietary curcumin by Chang, W., Weaver, CM, Medalla, M., Moore, TL, Luebke, JI

“…•Spatial working memory (WM) performance begins to decline in middle age•Pyramidal neurons exhibit hyperexcitability and spine loss beginning in middle…”
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Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortex by Luebke, J.I, Chang, Y.-M, Moore, T.L, Rosene, D.L

“…Executive system function, mediated largely by the prefrontal cortex (PFC), often declines significantly with normal aging in humans and non-human primates…”
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Effects of aging on the electrophysiological properties of layer 5 pyramidal cells in the monkey prefrontal cortex by Luebke, J.I, Chang, Y.-M

“…Abstract A significant decline in executive system function mediated by the prefrontal cortex (PFC) often occurs with normal aging. In vitro slice studies have…”
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Dendritic spine changes associated with normal aging by Dickstein, D.L, Weaver, C.M, Luebke, J.I, Hof, P.R

“…Highlights ► Effects of normal aging on neuronal loss, dendrites, and spines are region-specific. ► In many brain areas, normal aging is accompanied by…”
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Calcium influx through presynaptic 5-HT3 receptors facilitates GABA release in the hippocampus: In vitro slice and synaptosome studies by TURNER, T. J, MOKLER, D. J, LUEBKE, J. I

“…Serotonin 5-hydroxytryptamine type 3 receptors (5HT3R) are Ca2+-permeant, non-selective cation channels that have been localized to presynaptic terminals and…”
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Serotonin Hyperpolarizes Cholinergic Low-Threshold Burst Neurons in the Rat Laterodorsal Tegmental Nucleus in vitro by Luebke, J. I., Greene, R. W., Semba, K., Kamondi, A., McCarley, R. W., Reiner, P. B.

“…Serotonergic suppression of cholinergic neuronal activity implicated in the regulation of rapid eye movement sleep and its associated phenomenon,…”
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Age-related increase of sI(AHP) in prefrontal pyramidal cells of monkeys: relationship to cognition by Luebke, J I, Amatrudo, J M

“…Reduced excitability, due to an increase in the slow afterhyperpolarization (and its underlying current sI(AHP)), occurs in CA1 pyramidal cells in aged…”
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Multiple calcium channel types control glutamatergic synaptic transmission in the hippocampus by Luebke, J I, Dunlap, K, Turner, T J

“…N-type calcium channels play a dominant role in controlling synaptic transmission in many peripheral neurons. Transmitter release from mammalian central nerve…”
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Inhibitory action of muscarinic agonists on neurons in the rat laterodorsal tegmental nucleus in vitro by Luebke, J I, McCarley, R W, Greene, R W

“…1. The effects of the mixed cholinergic agonist carbachol and the muscarinic agonist methacholine (MCh) on neurons of the laterodorsal tegmental nucleus (LDT)…”
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Age-related increase of sIAHP in prefrontal pyramidal cells of monkeys: relationship to cognition by Luebke, J.I, Amatrudo, J.M

“…Abstract Reduced excitability, due to an increase in the slow afterhyperpolarization (and its underlying current sIAHP ), occurs in CA1 pyramidal cells in aged…”
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Age-Related Changes to Layer 3 Pyramidal Cells in the Rhesus Monkey Visual Cortex by Luebke, J. I., Medalla, M., Amatrudo, J. M., Weaver, C. M., Crimins, J. L., Hunt, B., Hof, P. R., Peters, A.

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Characterization of superior cervical ganglion neurons that project to the submandibular glands, the eyes, and the pineal gland in rats by Luebke, J I, Wright, L L

“…These studies sought to determine whether the cell bodies of rat superior cervical ganglion neurons projecting to three very different target organs differ in…”
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Distribution of NADPH-diaphorase positive somata in the brainstem of the monitor lizard Varanus exanthematicus by Luebke, J I, Weider, J M, McCarley, R W, Greene, R W

“…The distribution and size of presumptive cholinergic somata in the brainstem of the Savanna monitor lizard Varanus exanthematicus were determined using the…”
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Somatostatin-, vasoactive intestinal polypeptide- and neuropeptide Y-like immunoreactivity in eye- and submandibular gland-projecting sympathetic neurons by Wright, L L, Luebke, J I

“…Studies combine the use of the retrograde tracer, fluorogold, and immunocytochemical staining to determine whether superior cervical ganglion (SCG) neurons…”
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Exocytotic Ca2+ channels in mammalian central neurons by DUNLAP, K, LUEBKE, J. I, TURNER, T. J

“…Intracellular Ca2+ initiates physiological events as diverse as gene transcription, muscle contraction, cell division and exocytosis. Predictably, the…”
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Identification of Calcium Channels That Control Neurosecretion by Dunlap, Kathleen, Luebke, Jennifer I., Turner, Timothy J., Wheeler, David B., Tsien, Richard W., Randall, Andrew

“…Abstract only…”
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Labelling and recording from dissociated target-specific rat superior cervical ganglion neurons by Luebke, J I, Weight, F F, Aguayo, L G

“…A population of neurons was retrogradely labelled in the superior cervical ganglia (SCG) of the adult rat following the injection of the fluorescent dye Fast…”
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Prenatal Protein Malnutrition Results in Increased Frequency of Miniature Inhibitory Postsynaptic Currents in Rat CA3 Interneurons by Chang, Yu-Ming, Galler, Janina R., Luebke, Jennifer I.

“…Electrophysiological studies have revealed an increase in the level of tonic inhibition in the hippocampus following prenatal protein malnutrition in rats. In…”
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