Search Results - "LUDWIG, Joseph A"

Biomarkers in Cancer Staging, Prognosis and Treatment Selection by Weinstein, John N, Ludwig, Joseph A

“…Advances in genomics, proteomics and molecular pathology have generated many candidate biomarkers with potential clinical value. Their use for cancer staging…”
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Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma by Santoro, Marco, Lamhamedi-Cherradi, Salah-Eddine, Menegaz, Brian A., Ludwig, Joseph A., Mikos, Antonios G.

“…Three-dimensional tumor models accurately describe different aspects of the tumor microenvironment and are readily available for mechanistic studies of tumor…”
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Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells by SATELLI, Arun, MITRA, Abhisek, LUDWIG, Joseph A, KLEINERMAN, Eugenie S, SHULIN LI, CUTRERA, Jeffry J, DEVARIE, Marcos, XUEQING XIA, INGRAM, Davis R, DIBRA, Denada, SOMAIAH, Neeta, TORRES, Keila E, RAVI, Vinod

“…To date, no specific marker exists for the detection of circulating tumor cells (CTC) from different types of sarcomas, though tools are available for…”
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Modeling Ewing sarcoma tumors in vitro with 3D scaffolds by Fong, Eliza Li Shan, Lamhamedi-Cherradi, Salah-Eddine, Burdett, Emily, Ramamoorthy, Vandhana, Lazar, Alexander J., Kasper, F. Kurtis, Farach-Carson, Mary C., Vishwamitra, Deeksha, Demicco, Elizabeth G., Menegaz, Brian A., Amin, Hesham M., Mikos, Antonios G., Ludwig, Joseph A.

“…The pronounced biological influence of the tumor microenvironment on cancer progression and metastasis has gained increased recognition over the past decade,…”
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Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival by Subbiah, Vivek, Lamhamedi-Cherradi, Salah-Eddine, Cuglievan, Branko, Menegaz, Brian A, Camacho, Pamela, Huh, Winston, Ramamoorthy, Vandhana, Anderson, Pete M, Pollock, Raphael E, Lev, Dina C, Qiao, Wei, McAleer, Mary Frances, Benjamin, Robert S, Patel, Shreyaskumar, Herzog, Cynthia E, Daw, Najat C, Feig, Barry W, Lazar, Alexander J, Hayes-Jordan, Andrea, Ludwig, Joseph A

“…Desmoplastic small round cell tumor (DSRCT), which harbors EWSR1-WT1 t(11;22)(p13:q12) chromosomal translocation, is an aggressive malignancy that typically…”
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Activity of temozolomide and bevacizumab in the treatment of locally advanced, recurrent, and metastatic hemangiopericytoma and malignant solitary fibrous tumor by Park, Min S., Patel, Shreyaskumar R., Ludwig, Joseph A., Trent, Jonathan C., Conrad, Charles A., Lazar, Alexander J., Wang, Wei‐Lien, Boonsirikamchai, Piyaporn, Choi, Haesun, Wang, Xuemei, Benjamin, Robert S., Araujo, Dejka M.

“…BACKGROUND: Hemangiopericytomas and malignant solitary fibrous tumors (HPC/SFT) are rare, closely related sarcomas with unpredictable behavior that respond…”
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Commentary: A Special Edition in bone sarcoma by Ludwig, Joseph A, Van Tine, Brian

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Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing by Truong, Danh D, Lamhamedi-Cherradi, Salah-Eddine, Porter, Robert W, Krishnan, Sandhya, Swaminathan, Jyothishmathi, Gibson, Amber, Lazar, Alexander J, Livingston, J Andrew, Gopalakrishnan, Vidya, Gordon, Nancy, Daw, Najat C, Navin, Nicholas E, Gorlick, Richard, Ludwig, Joseph A

“…Single-cell RNA-seq has emerged as an innovative technology used to study complex tissues and characterize cell types, states, and lineages at a single-cell…”
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Targeting the IGF/PI3K/mTOR pathway and AXL/YAP1/TAZ pathways in primary bone cancer by Truong, Danh D., Lamhamedi-Cherradi, Salah-Eddine, Ludwig, Joseph A.

“…•Our manuscript summarizes the critical role that the IGF/PI3K/mTOR and YAP/TAZ pathways play in bone sarcoma tumor progression.•It highlights the successes…”
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Novel secondary somatic mutations in Ewing's sarcoma and desmoplastic small round cell tumors by Jiang, Yunyun, Subbiah, Vivek, Janku, Filip, Ludwig, Joseph A, Naing, Aung, Benjamin, Robert S, Brown, Robert E, Anderson, Pete, Kurzrock, Razelle

“…Ewing's sarcoma (ES) and desmoplastic small round cell tumors (DSRCT) are small round blue cell tumors driven by an N-terminal containing EWS translocation…”
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Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Kidney: The MD Anderson Cancer Center Experience by Tarek, Nidale, Said, Rabih, Andersen, Clark R, Suki, Tina S, Foglesong, Jessica, Herzog, Cynthia E, Tannir, Nizar M, Patel, Shreyaskumar, Ratan, Ravin, Ludwig, Joseph A, Daw, Najat C

“…Limited information exists on the clinical behavior of the Ewing sarcoma family of tumors (ESFT) of the kidney. We reviewed the records of 30 patients (aged…”
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Efficacy of ONC201 in Desmoplastic Small Round Cell Tumor by Hayes-Jordan, Andrea A., Ma, Xiao, Menegaz, Brian A., Lamhamedi-Cherradi, Salah-Eddine, Kingsley, Charles V., Benson, Jalen A., Camacho, Pamela E., Ludwig, Joseph A., Lockworth, Cynthia R., Garcia, Gloria E., Craig, Suzanne L.

“…Desmoplastic Small Round Cell Tumor (DSRCT) is a rare sarcoma tumor of adolescence and young adulthood, which harbors a recurrent chromosomal translocation…”
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Ewing’s Sarcoma: Standard and Experimental Treatment Options by Subbiah, Vivek, Anderson, Pete, Lazar, Alexander J., Burdett, Emily, Raymond, Kevin, Ludwig, Joseph A.

“…Opinion statement Ewing sarcoma family tumors (EWS), which include classic Ewing’s sarcoma in addition to primitive neuroectodermal tumor and Askin tumor, are…”
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Prognostic Factors and Patterns of Relapse in Ewing Sarcoma Patients Treated With Chemotherapy and R0 Resection by Pan, Hubert Y., MD, Morani, Ajaykumar, MD, Wang, Wei-Lien, MD, Hess, Kenneth R., PhD, Paulino, Arnold C., MD, Ludwig, Joseph A., MD, Lin, Patrick P., MD, Daw, Najat C., MD, Mahajan, Anita, MD

“…Purpose To identify prognostic factors and patterns of relapse for patients with Ewing sarcoma who underwent chemotherapy and R0 resection without radiation…”
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SARC006: Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated Chemotherapy-Naive Malignant Peripheral Nerve Sheath Tumors by Higham, Christine S., Steinberg, Seth M., Dombi, Eva, Perry, Arie, Helman, Lee J., Schuetze, Scott M., Ludwig, Joseph A., Staddon, Arthur, Milhem, Mohammed M., Rushing, Daniel, Jones, Robin L., Livingston, Michael, Goldman, Stewart, Moertel, Christopher, Wagner, Lars, Janhofer, David, Annunziata, Christina M., Reinke, Denise, Long, Lauren, Viskochil, David, Baker, Larry, Widemann, Brigitte C.

“…Background. Worse chemotherapy response for neurofibromatosis type 1- (NF1-) associated compared to sporadic malignant peripheral nerve sheath tumors (MPNST)…”
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IGF-1R/mTOR Targeted Therapy for Ewing Sarcoma: A Meta-Analysis of Five IGF-1R-Related Trials Matched to Proteomic and Radiologic Predictive Biomarkers by Amin, Hesham M, Morani, Ajaykumar C, Daw, Najat C, Lamhamedi-Cherradi, Salah-Eddine, Subbiah, Vivek, Menegaz, Brian A, Vishwamitra, Deeksha, Eskandari, Ghazaleh, George, Bhawana, Benjamin, Robert S, Patel, Shreyaskumar, Song, Juhee, Lazar, Alexander J, Wang, Wei-Lien, Kurzrock, Razelle, Pappo, Alberto, Anderson, Peter M, Schwartz, Gary K, Araujo, Dejka, Cuglievan, Branko, Ratan, Ravin, McCall, David, Mohiuddin, Sana, Livingston, John A, Molina, Eric R, Naing, Aung, Ludwig, Joseph A

“…: Ten to fourteen percent of Ewing sarcoma (ES) study participants treated nationwide with IGF-1 receptor (IGF-1R)-targeted antibodies achieved tumor…”
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Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer by LUDWIG, Joseph A, SZAKACS, Gergely, GOTTESMAN, Michael M, MARTIN, Scott E, CHU, Benjamin F, CARDARELLI, Carol, SAUNA, Zuben E, CAPLEN, Natasha J, FALES, Henry M, AMBUDKAR, Suresh V, WEINSTEIN, John N

“…ATP-binding cassette (ABC) proteins include the best known mediators of resistance to anticancer drugs. In particular, ABCB1 [MDR1/P-glycoprotein (P-gp)]…”
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Clinical characteristics and outcomes of adult alveolar rhabdomyosarcoma patients on first-line systemic therapies: A single-institution cohort by Nakazawa, Michael S, Livingston, J Andrew, Zarzour, Maria A, Bishop, Andrew J, Ratan, Ravin, Ludwig, Joseph A, Araujo, Dejka M, Somaiah, Neeta, Ravi, Vinod, Nassif, Elise F, Roland, Christina L, Lazar, Alexander J, Guadagnolo, B Ashleigh, Harrison, Douglas J, Benjamin, Robert S, Patel, Shreyaskumar R, Conley, Anthony P

“…Rhabdomyosarcomas are the most common soft tissue sarcoma in children, and pediatric alveolar rhabdomyosarcoma (ARMS) prognosis has improved based on…”
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Enzalutamide induces cytotoxicity in desmoplastic small round cell tumor independent of the androgen receptor by Magrath, Justin W., Goldberg, Ilon N., Truong, Danh D., Hartono, Alifiani B., Sampath, Shruthi Sanjitha, Jackson, Chandler E., Ghosh, Anushka, Cardin, Derrick L., Zhang, Haitao, Ludwig, Joseph A., Lee, Sean B.

“…Desmoplastic Small Round Cell Tumor (DSRCT) is a rare, pediatric cancer caused by the EWSR1::WT1 fusion protein. DSRCT predominantly occurs in males, which…”
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Multi-site desmoplastic small round cell tumors are genetically related and immune-cold by Wu, Chia-Chin, Beird, Hannah C., Lamhamedi-Cherradi, Salah-Eddine, Soeung, Melinda, Ingram, Davis, Truong, Danh D., Porter, Robert W., Krishnan, Sandhya, Little, Latasha, Gumbs, Curtis, Zhang, Jianhua, Titus, Mark, Genovese, Giannicola, Ludwig, Joseph A., Lazar, Alexander J., Hayes-Jordan, Andrea, Futreal, P. Andrew

“…Desmoplastic small round cell tumor (DSRCT) is a highly aggressive soft tissue sarcoma that is characterized by the EWSR1-WT1 fusion protein. Patients present…”
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