Search Results - "LUDWIG, E. A"

Population Pharmacokinetics of Tigecycline in Patients with Complicated Intra-Abdominal or Skin and Skin Structure Infections by VAN WART, S. A, OWEN, J. S, LUDWIG, E. A, MEAGHER, A. K, KORTH-BRADLEY, J. M, CIRINCIONE, B. B

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynamics by Lew, K H, Ludwig, E A, Milad, M A, Donovan, K, Middleton, Jr, E, Ferry, J J, Jusko, W J

“…The pharmacokinetics and selected pharmacodynamic responses to methylprednisolone were investigated in six men and six premenopausal women after a dose of 0.6…”
Get more information

Oral contraceptive effects on methylprednisolone pharmacokinetics and pharmacodynamics by Slayter, K L, Ludwig, E A, Lew, K H, Middleton, Jr, E, Ferry, J J, Jusko, W J

“…Oral contraceptive (OC) steroids alter the disposition of numerous drugs, including corticosteroids. We investigated the pharmacokinetics and pharmacodynamics…”
Get more information

Population Pharmacokinetics of Tigecycline in Healthy Volunteers by Van Wart, S. A., Cirincione, B. B., Ludwig, E. A., Meagher, A. K., Korth-Bradley, J. M., Owen, J. S.

“…Tigecycline, a novel glycylcycline, possesses broad‐spectrum antimicrobial activity. A structural population pharmacokinetic model for tigecycline was…”
Get full text

Pharmacokinetics and pharmacodynamics of methylprednisolone in obesity by Dunn, T E, Ludwig, E A, Slaughter, R L, Camara, D S, Jusko, W J

“…Methylprednisolone pharmacokinetics and its directly suppressive effects on plasma cortisol, blood histamine (basophils), and circulating helper T cells were…”
Get more information

Methylprednisolone pharmacokinetics and pharmacodynamics in chronic renal failure by Jusko, W J, Milad, M A, Ludwig, E A, Lew, K H, Kohli, R K

“…Methylprednisolone (MP) pharmacokinetics and its directly suppressive effects on cortisol secretion and cell trafficking were compared in 6 chronic renal…”
Get more information

Pharmacokinetics and pharmacodynamic modeling of direct suppression effects of methylprednisolone on serum cortisol and blood histamine in human subjects by Kong, A N, Ludwig, E A, Slaughter, R L, DiStefano, P M, DeMasi, J, Middleton, Jr, E, Jusko, W J

“…Pharmacodynamic models for "directly suppressive" effects of methylprednisolone are based on the premise that receptor interactions of steroids are followed by…”
Get more information

Lack of pharmacokinetic and pharmacodynamic interactions between ketoconazole and prednisolone by Yamashita, S K, Ludwig, E A, Middleton, Jr, E, Jusko, W J

“…The effects of ketoconazole on the pharmacokinetics and pharmacodynamics of intravenous prednisolone (14.8 mg) were assessed in six healthy volunteers…”
Get more information

Pharmacokinetics and pharmacodynamics of methylprednisolone when administered at 8 am versus 4 pm by Fisher, L E, Ludwig, E A, Wald, J A, Sloan, R R, Middleton, Jr, E, Jusko, W J

“…The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 AM versus 4 PM were investigated in six healthy male…”
Get more information

Pharmacokinetics of methylprednisolone hemisuccinate and methylprednisolone in chronic liver disease by Ludwig, E A, Kong, A N, Camara, D S, Jusko, W J

“…The disposition of methylprednisolone (MP) and its prodrug hemisuccinate (MPHS) was assessed in six middle-aged patients with chronic liver disease (CLD) and…”
Get more information

Evaluation of dose-related pharmacokinetics and pharmacodynamics of prednisolone in man by Wald, J A, Law, R M, Ludwig, E A, Sloan, R R, Middleton, Jr, E, Jusko, W J

“…The pharmacokinetics and pharmacodynamics of prednisolone were evaluated in normal male volunteers. Seven subjects completed 3 phases: 16.4- and 49.2-mg iv…”
Get more information

A population pharmacokinetic-pharmacodynamic analysis and model validation of azimilide by Phillips, L

Get full text

Steroid-specific effects of ketoconazole on corticosteroid disposition: unaltered prednisolone elimination by Ludwig, E A, Slaughter, R L, Savliwala, M, Brass, C, Jusko, W J

“…Ketoconazole inhibits the clearance of methylprednisolone by 60 percent and extends cortisol suppression beyond that produced by methylprednisolone alone. This…”
Get more information

THE EFFECTS OF REINFORCER MAGNITUDE ON TIMING IN RATS by Ludvig, Elliot A., Conover, Kent, Shizgal, Peter

“…The relation between reinforcer magnitude and timing behavior was studied using a peak procedure. Four rats received multiple consecutive sessions with both…”
Get full text

Pharmacoimmunodynamics of methylprednisolone: trafficking of helper T lymphocytes by Fisher, L E, Ludwig, E A, Jusko, W J

“…A two-compartment closed model was used to characterize the cell trafficking behavior of helper T cells in response to various single doses of…”
Get more information

Steroid dose sparing: pharmacodynamic responses to single versus divided doses of methylprednisolone in man by Reiss, W G, Slaughter, R L, Ludwig, E A, Middleton, Jr, E, Jusko, W J

“…Inhibitory drug interactions affecting the metabolism of methylprednisolone (MP) may produce either steroid sparing or adverse effects partly by increasing the…”
Get more information

Pharmacodynamic model for joint exogenous and endogenous corticosteroid suppression of lymphocyte trafficking by Milad, M A, Ludwig, E A, Anné, S, Middleton, Jr, E, Jusko, W J

“…The circadian pattern of the immune system correlates with that of circulating T-helper cells and inversely with cortisol concentrations. Corticosteroids, both…”
Get more information

OI-A-1 by Van Wart, S. A., Cirincione, B. B., Ludwig, E. A., Chen, X., Shoaf, S., Grasela, T. H., Mallikaarjun, S.

“…AIM TOL is a oral vasopressin (V2) receptor antagonist under development for treatment of CHF and/or HYP. Direct and indirect effect PK/PD models were…”
Get full text

PIII-10 by Van Wart, S. A., Cirincione, B. B., Ludwig, E. A., Chen, X., Shoaf, S., Grasela, T. H., Mallikaarjun, S.

“…AIM Direct effect, indirect effect, and competitive antagonism models were evaluated to describe plasma TOL concentration (Cp) effect on urine flow rate (UFR),…”
Get full text

ENVIRONMENTAL PROTECTION IN THE NETHERLANDS by BRIET, LUDWIG A. E.

Get full text