Search Results - "LUDOVICI, Donald W"

Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants by Das, Kalyan, Clark, Arthur D, Lewi, Paul J, Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Vinkers, H. Maarten, Daeyaert, Frederik, Ludovici, Donald W, Kukla, Michael J, De Corte, Bart, Kavash, Robert W, Ho, Chih Y, Ye, Hong, Lichtenstein, Mark. A, Andries, Koen, Pauwels, Rudi, de Béthune, Marie-Pierre, Boyer, Paul L, Clark, Patrick, Hughes, Stephen H, Janssen, Paul A. J, Arnold, Eddy

“…Anti-AIDS drug candidate and non-nucleoside reverse transcriptase inhibitor (NNRTI) TMC125-R165335 (etravirine) caused an initial drop in viral load similar to…”
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Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists by Zhu, Bin, Xia, Mingde, Xu, Xiaoqing, Ludovici, Donald W., Tennakoon, Manomi, Youngman, Mark A., Matthews, Jay M., Dax, Scott L., Colburn, Raymond W., Qin, Ning, Hutchinson, Tasha L., Lubin, Mary Lou, Brandt, Michael R., Stone, Dennis J., Flores, Christopher M., Macielag, Mark J.

“…A series of arylglycine-based analogs was synthesized and tested for TRPM8 antagonism in a cell-based functional assay. Following structure–activity…”
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Evolution of anti-HIV drug candidates. Part 3: diarylpyrimidine (DAPY) analogues by Ludovici, Donald W., De Corte, Bart L., Kukla, Michael J., Ye, Hong, Ho, Chih Y., Lichtenstein, Mark A., Kavash, Robert W., Andries, Koen, de Béthune, Marie-Pierre, Azijn, Hilde, Pauwels, Rudi, Lewi, Paul J., Heeres, Jan, Koymans, Lucien M.H., de Jonge, Marc R., Van Aken, Koen J.A., Daeyaert, Frederik F.D., Das, Kalyan, Arnold, Edward, Janssen, Paul A.J.

“…The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAPYs) are described. Several members of this novel class of non-nucleoside reverse…”
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Evolution of anti-HIV drug candidates. Part 2 : Diaryltriazine (DATA) analogues by LUDOVICI, Donald W, KAVASH, Robert W, MOEREELS, Henry E. L, HEERES, Jan, KOYMANS, Lucien M. H, DE JONGE, Marc R, VAN AKEN, Koen J. A, DAEYAERT, Frederik F. D, LEWI, Paul J, DAS, Kalyan, ARNOLD, Edward, JANSSEN, Paul A. J, KUKLA, Michael J, HO, Chih Y, HONG YE, DE CORTE, Bart L, ANDRIES, Koen, DE BETHUNE, Marie-Pierre, AZIJN, Hilde, PAUWELS, Rudi

“…A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the…”
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Evolution of anti-HIV drug candidates. Part 1: From α-Anilinophenylacetamide (α-APA) to imidoyl thiourea (ITU) by Ludovici, Donald W., Kukla, Michael J., Grous, Philip G., Krishnan, Suma, Andries, Koen, de Béthune, Marie-Pierre, Azijn, Hilde, Pauwels, Rudi, De Clercq, Erik, Arnold, Edward, Janssen, Paul A.J.

“…Stemming from work on a previous clinical candidate, loviride, and other α-APA derivatives, a new series of potent non-nucleoside reverse transcriptase…”
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(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines:  Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors with Broad Antiproliferative Activity against Tumor Cells by Ho, Chih Y, Ludovici, Donald W, Maharoof, Umar S. M, Mei, Jay, Sechler, Jan L, Tuman, Robert W, Strobel, Eric D, Andraka, Laura, Yen, Hwa-Kwo, Leo, Gregory, Li, Jian, Almond, Harold, Lu, Hong, DeVine, Ann, Tominovich, Rose M, Baker, Judith, Emanuel, Stuart, Gruninger, Robert H, Middleton, Steven A, Johnson, Dana L, Galemmo, Robert A

“…A series of (6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines has been optimized to preserve both potent kinase inhibition activity against the…”
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Synthesis and Anti-HIV-1 Activity of 4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) Derivatives. 3 by Breslin, Henry J, Kukla, Michael J, Ludovici, Donald W, Mohrbacher, Richard, Ho, Winston, Miranda, Milton, Rodgers, James D, Hitchens, T. Kevin, Leo, Gregory

“…4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2 (1H)-ones (TIBO), 1, have been shown to significantly inhibit HIV-1 replication in vitro by…”
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Synthesis and Anti-HIV-1 Activity of 4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TlBO) Derivatives. 4 by Ho, Winston, Kukla, Michael J, Breslin, Henry J, Ludovici, Donald W, Grous, Philip P, Diamond, Craig J, Miranda, Milton, Rodgers, James D, Ho, Chih Y

“…In previous papers, we have described the discovery of a new series of compounds, 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1 H)- ones,…”
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Preparation and reactions of some derivatives of 2,4-benzodiazepines and 1,3-diazepines by Heine, Harold W, Ludovici, Donald W, Pardoen, Johannes A, Weber, Robert C, Bonsall, Eric, Osterhout, Keith R

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Evolution of Anti-HIV Drug CandidatesPart 2: Diaryltriazine (DATA) Analogues by Ludovici, Donald W., Kavash, Robert W., Kukla, Michael J., Ho, Chih Y., Ye, Hong, De Corte, Bart L., Andries, Koen, de Béthune, Marie-Pierre, Azijn, Hilde, Pauwels, Rudi, Moereels, Henry E.L., Heeres, Jan, Koymans, Lucien M.H., de Jonge, Marc R., Van Aken, Koen J.A., Daeyaert, Frederik F.D., J. Lewi, Paul, Das, Kalyan, Arnold, Edward, Janssen, Paul A.J.

“…A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the…”
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