Search Results - "LUDEWIG, G"

PCB153 reduces telomerase activity and telomere length in immortalized human skin keratinocytes (HaCaT) but not in human foreskin keratinocytes (NFK) by Senthilkumar, P.K., Robertson, L.W., Ludewig, G.

“…Polychlorinated biphenyls (PCBs), ubiquitous environmental pollutants, are characterized by long term-persistence in the environment, bioaccumulation, and…”
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Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat) by Senthilkumar, P.K., Klingelhutz, A.J., Jacobus, J.A., Lehmler, H., Robertson, L.W., Ludewig, G.

“…PCBs, a group of 209 individual congeners, are ubiquitous environmental pollutants and classified as probable human carcinogens. One major route of exposure is…”
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Metallothionein's role in PCB126 induced hepatotoxicity and hepatic micronutrient disruption by Klaren, W D, Flor, S, Gibson-Corley, K N, Ludewig, G, Robertson, L W

“…Polychlorinated biphenyls (PCBs), industrial chemicals and persistent environmental pollutants, are found in rural and urban settings. Rodent studies have…”
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Production of DNA Strand Breaks in Vitro and Reactive Oxygen Species in Vitro and in HL-60 Cells by PCB Metabolites by Srinivasan, Anandi, Lehmler, Hans-Joachim, Robertson, Larry W., Ludewig, Gabriele

“…PCBs are industrial chemicals that continue to contaminate our environment. They cause various toxic effects in animals and in exposed human populations. The…”
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A low halogenated biphenyl (PCB3) increases CYP1A1 expression and activity via the estrogen receptor beta in the porcine ovary by Ptak, A, Ludewig, G, Gregoraszczuk, E Ł

“…Polychlorinated biphenyls (PCBs) have been detected at high levels, up to hundreds of pg/ml, in human ovarian follicle fluid. The effect of PCBs on the ovary…”
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3-Methylcholanthrene (3-MC) and 4-chlorobiphenyl (PCB3) genotoxicity is gender-related in Fischer 344 transgenic rats by Jacobus, J.A., Wang, B., Maddox, C., Esch, H., Lehmann, L., Robertson, L.W., Wang, K., Kirby, P., Ludewig, G.

“…Polychlorinated biphenyls (PCBs) are a class of persistent organic pollutants with myriad biological effects, including carcinogenicity. We present data…”
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Synthesis, physicochemical properties and in vitro cytotoxicity of nicotinic acid ester prodrugs intended for pulmonary delivery using perfluorooctyl bromide as vehicle by Lehmler, Hans-Joachim, Xu, Ling, Vyas, Sandhya M., Ojogun, Vivian A., Knutson, Barbara L., Ludewig, Gabriele

“…This study explores perfluorooctyl bromide (PFOB) as a potential vehicle for the pulmonary delivery of a series of prodrugs of nicotinic acid using cell…”
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Sulfhydryl Binding and Topoisomerase Inhibition by PCB Metabolites by Srinivasan, A, Robertson, L. W, Ludewig, G

“…Polychlorinated biphenyls (PCBs) are highly persistent contaminants in our environment. Their persistence is due to a general resistance to metabolic attack…”
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2-(4′-chlorophenyl)-1,4-benzoquinone increases the frequency of micronuclei and shortens telomeres by Jacobus, J.A, Flor, S, Klingelhutz, A.J, Robertson, L.W, Ludewig, G

“…Abstract The toxicity of polychlorinated biphenyls (PCBs) has been attributed widely to receptor-mediated effects, buttressed by the popularity of the toxic…”
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Metabolism and metabolites of polychlorinated biphenyls by Grimm, Fabian A., Hu, Dingfei, Kania-Korwel, Izabela, Lehmler, Hans-Joachim, Ludewig, Gabriele, Hornbuckle, Keri C., Duffel, Michael W., Bergman, Åke, Robertson, Larry W.

“…Abstract The metabolism of polychlorinated biphenyls (PCBs) is complex and has an impact on toxicity, and thereby on the assessment of PCB risks. A large…”
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Characterization of the PNT1 pentamidine resistance gene of Saccharomyces cerevisiae by LUDEWIG, G, STABEN, C

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Ovarian toxicity following exposure to polychlorinated biphenyl 126 is mediated by the aryl hydrocarbon receptor by Klenov, V., Flor, S., Ganesan, S., Clark, K.L., Eti, N., Iqbal, K., Soares, M.J., Ludewig, G., Keating, A.F., Robertson, L.W.

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Mechanisms of toxicity of PCB metabolites: generation of reactive oxygen species and glutathione depletion by Ludewig, G, Srinivasan, A, Robertson, L W

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Effects of pentamidine isethionate on Saccharomyces cerevisiae by Ludewig, G, Williams, J M, Li, Y, Staben, C

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PCB153 reduces Telomerase Activity and Telomere Length in Immortalized Human Skin Kerantinocytes (HaCaT) but not in Human Foreskin Keratinocytes (NFK) by Senthilkumar, P.K., Robertson, L.W., Ludewig, G.

“…Polychlorinated Biphenyls (PCBs), ubiquitous environmental pollutants, are characterized by long term-persistence in the environment, bioaccumulation, and…”
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Multiple Activation Pathways of Benzene Leading to Products with Varying Genotoxic Characteristics by Glatt, Hansruedi, Padykula, Robert, Berchtold, Glenn A., Ludewig, Gabriele, Platt, Karl L., Klein, Jochen, Oesch, Franz

“…Benzene and 13 potential metabolites were investigated for genotoxicity in Salmonella typhimurium and V79 Chinese hamster cells. In the presence of…”
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A mutation found in the promoter region of the human survivin gene is correlated to overexpression of survivin in cancer cells by Xu, Yong, Fang, Fang, Ludewig, Gabriele, Jones, Grace, Jones, Davy

“…Survivin, a unique antiapoptotic factor, plays an important role in cell cycle regulation. Numerous clinical studies have shown that survivin is markedly…”
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Genotoxicity of 1,4-Benzoquinone and 1,4-Naphthoquinone in Relation to Effects on Glutathione and NAD(P)H Levels in V79 Cells by Ludewig, Gabriele, Dogra, Satish, Glatt, Hansruedi

“…1,4-Benzoquinone is cytotoxic in V79 Chinese hamster cells and induces gene mutations and micronuclei. The cell-damaging effects of quinones are usually…”
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Sensitivity of taxonomically diverse fungi to pentamidine isethionate by Ludewig, G, Staben, C

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Metabolism and activation of polychlorinated biphenyls (PCBs) by Robertson, L W, Espandiari, P, Lehmler, H J, Pereg, D, Srinivasan, A, Tampal, N, Twaroski, T, Ludewig, G, Glauert, H P, Arif, J, Gupta, R

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