Search Results - "LUCKENBAUGH, David A"

Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial by Zarate, Carlos A, Brutsche, Nancy E, Ibrahim, Lobna, Franco-Chaves, Jose, Diazgranados, Nancy, Cravchik, Anibal, Selter, Jessica, Marquardt, Craig A, Liberty, Victoria, Luckenbaugh, David A

“…Background Currently, no pharmacological treatments for bipolar depression exist that exert rapid (within hours) antidepressant or antisuicidal effects. We…”
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Do the dissociative side effects of ketamine mediate its antidepressant effects? by Luckenbaugh, David A, Niciu, Mark J, Ionescu, Dawn F, Nolan, Neal M, Richards, Erica M, Brutsche, Nancy E, Guevara, Sara, Zarate, Carlos A

“…Abstract Background The N-methyl- d -aspartate receptor antagonist ketamine has rapid antidepressant effects in major depression. Psychotomimetic symptoms,…”
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A Randomized Trial of a Low-Trapping Nonselective N -Methyl-D-Aspartate Channel Blocker in Major Depression by Zarate, Carlos A, Mathews, Daniel, Ibrahim, Lobna, Chaves, Jose Franco, Marquardt, Craig, Ukoh, Immaculata, Jolkovsky, Libby, Brutsche, Nancy E, Smith, Mark A, Luckenbaugh, David A

“…Background The high-affinity N -methyl-D-aspartate (NMDA) antagonist ketamine exerts rapid antidepressant effects but has psychotomimetic properties. AZD6765…”
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Neural correlates of change in major depressive disorder anhedonia following open-label ketamine by Lally, Níall, Nugent, Allison C, Luckenbaugh, David A, Niciu, Mark J, Roiser, Jonathan P, Zarate, Carlos A

“…Anhedonia is a cardinal symptom of major depression and is often refractory to standard treatment, yet no approved medication for this specific symptom exists…”
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Features of dissociation differentially predict antidepressant response to ketamine in treatment-resistant depression by Niciu, Mark J., Shovestul, Bridget J., Jaso, Brittany A., Farmer, Cristan, Luckenbaugh, David A., Brutsche, Nancy E., Park, Lawrence T., Ballard, Elizabeth D., Zarate, Carlos A.

“…Ketamine induces rapid and robust antidepressant effects, and many patients also describe dissociation, which is associated with antidepressant response. This…”
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Course of Improvement in Depressive Symptoms to a Single Intravenous Infusion of Ketamine vs Add-on Riluzole: Results from a 4-Week, Double-Blind, Placebo-Controlled Study by IBRAHIM, Lobna, DIAZGRANADOS, Nancy, ZARATE, Carlos A, FRANCO-CHAVES, Jose, BRUTSCHE, Nancy, HENTER, Ioline D, KRONSTEIN, Phillip, MOADDEL, Ruin, WAINER, Irving, LUCKENBAUGH, David A, MANJI, Husseini K

“…The N-methyl-D-aspartate antagonist ketamine has rapid antidepressant effects in patients with treatment-resistant major depression (TRD); these effects have…”
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Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: ketamine and other compounds by Niciu, Mark J, Henter, Ioline D, Luckenbaugh, David A, Zarate, Jr, Carlos A, Charney, Dennis S

“…The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has rapid and potent antidepressant effects in treatment-resistant major depressive disorder and…”
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Early-Onset Bipolar Disorder and Treatment Delay Are Risk Factors for Poor Outcome in Adulthood by POST, Robert M, LEVERICH, Gabriele S, SUPPES, Trisha, NOLEN, Willem A, KUPKA, Ralph W, KECK, Paul E, MCELROY, Susan L, ALTSHULER, Lori L, FRYE, Mark A, LUCKENBAUGH, David A, ROWE, Michael, GRUNZE, Heinz

“…We examined the influence of age at onset of illness and the delay in time to first treatment on morbidity in adulthood. 529 adult outpatients with a mean age…”
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Automated subcortical segmentation using FIRST: Test-retest reliability, interscanner reliability, and comparison to manual segmentation by Nugent, Allison C., Luckenbaugh, David A., Wood, Suzanne E., Bogers, Wendy, Zarate Jr, Carlos A., Drevets, Wayne C

“…Multiple techniques exist for the automated segmentation of magnetic resonance images (MRIs). The validity of these techniques can be assessed by evaluating…”
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Probing for hemispheric specialization for motor skill learning: a transcranial direct current stimulation study by Schambra, Heidi M, Abe, Mitsunari, Luckenbaugh, David A, Reis, Janine, Krakauer, John W, Cohen, Leonardo G

“…Convergent findings point to a left-sided specialization for the representation of learned actions in right-handed humans, but it is unknown whether analogous…”
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Antidepressant treatment history as a predictor of response to scopolamine: clinical implications by Ellis, Jessica S, Zarate, Carlos A, Luckenbaugh, David A, Furey, Maura L

“…Abstract Background The intravenous administration of scopolamine produces rapid antidepressant effects. Generally, failing multiple previous antidepressant…”
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A Double-Blind, Placebo-Controlled Study of Memantine in the Treatment of Major Depression by Zarate, Carlos A., Singh, Jaskaran B., Quiroz, Jorge A., De Jesus, Georgette, Denicoff, Kirk K., Luckenbaugh, David A., Manji, Husseini K., Charney, Dennis S.

“…OBJECTIVE: This study was designed to assess possible antidepressant effects of memantine, a selective N-methyl-D-aspartate (NMDA) receptor antagonist in…”
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A randomized, placebo-controlled pilot trial of the delta opioid receptor agonist AZD2327 in anxious depression by Richards, Erica M., Mathews, Daniel C., Luckenbaugh, David A., Ionescu, Dawn F., Machado-Vieira, Rodrigo, Niciu, Mark J., Duncan, Wallace C., Nolan, Neal M., Franco-Chaves, Jose A., Hudzik, Thomas, Maciag, Carla, Li, Shuang, Cross, Alan, Smith, Mark A., Zarate, Carlos A.

“…Rationale Patients with anxious major depressive disorder (AMDD) have more severe symptoms and poorer treatment response than patients with non-AMDD…”
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Controlled Study of 50-Hz Repetitive Transcranial Magnetic Stimulation for the Treatment of Parkinson Disease by Benninger, David H., Iseki, Kazumi, Kranick, Sarah, Luckenbaugh, David A., Houdayer, Elise, Hallett, Mark

“…Objective. To investigate the safety and efficacy of 50-Hz repetitive transcranial magnetic stimulation (rTMS) in the treatment of motor symptoms in Parkinson…”
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Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study by Zarate Jr, Carlos A, Singh, Jaskaran B, Carlson, Paul J, Quiroz, Jorge, Jolkovsky, Libby, Luckenbaugh, David A, Manji, Husseini K

“…Objectives:  Considerable preclinical biochemical and behavioral data suggest that protein kinase C inhibition would bring about antimanic effects. Notably,…”
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Transcranial direct current stimulation for the treatment of focal hand dystonia by Benninger, David H., Lomarev, Mikhail, Lopez, Grisel, Pal, Natassja, Luckenbaugh, David A., Hallett, Mark

“…The treatment of writer's cramp, a task‐specific focal hand dystonia, needs new approaches. A deficiency of inhibition in the motor cortex might cause writer's…”
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Reduced Posterior Hippocampal Volume in Posttraumatic Stress Disorder by BONNE, Omer, VYTHILINGAM, Meena, CHARNEY, Dennis S, INAGAKI, Masatoshi, WOOD, Suzanne, NEUMEISTER, Alexander, NUGENT, Allison C, SNOW, Joseph, LUCKENBAUGH, David A, BAIN, Earle E, DREVETS, Wayne C

“…Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously…”
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Combining a dopamine agonist and selective serotonin reuptake inhibitor for the treatment of depression: A double-blind, randomized pilot study by Franco-Chaves, Jose A, Mateus, Camilo F, Luckenbaugh, David A, Martinez, Pedro E, Mallinger, Alan G, Zarate, Carlos A

“…Abstract Background Antidepressants that act on two or more amine neurotransmitters may confer higher remission rates when first-line agents affecting a single…”
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On quantitative relationships between drug-like compound lipophilicity and plasma free fraction in monkey and human by Zoghbi, Sami S, Anderson, Kacey B, Jenko, Kimberly J, Luckenbaugh, David A, Innis, Robert B, Pike, Victor W

“…Drug interactions with plasma proteins influence their pharmacokinetics and pharmacodynamics. We aimed to test whether a strong quantitative relationship…”
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Gender-specific abnormalities in the serotonin transporter system in panic disorder by Cannon, Dara M., Klaver, Jacqueline M., Klug, Summer A., Carlson, Paul J., Luckenbaugh, David A., Ichise, Masanori, Drevets, Wayne C.

“…The central serotonergic system has been implicated in the pathophysiology of panic disorder (PD) by evidence of abnormally elevated serotonin-turnover,…”
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