Search Results - "LUCIANO, A. A"

CRISPR-Cas immunity in prokaryotes by Marraffini, Luciano A.

“…Prokaryotic organisms are threatened by a large array of viruses and have developed numerous defence strategies. Among these, only clustered, regularly…”
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CRISPR-Cas Systems: Prokaryotes Upgrade to Adaptive Immunity by Barrangou, Rodolphe, Marraffini, Luciano A.

“…Clustered regularly interspaced short palindromic repeats (CRISPR), and associated proteins (Cas) comprise the CRISPR-Cas system, which confers adaptive…”
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Molecular mechanisms of CRISPR–Cas spacer acquisition by McGinn, Jon, Marraffini, Luciano A.

“…Many bacteria and archaea have the unique ability to heritably alter their genomes by incorporating small fragments of foreign DNA, called spacers, into CRISPR…”
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Degradation of Phage Transcripts by CRISPR-Associated RNases Enables Type III CRISPR-Cas Immunity by Jiang, Wenyan, Samai, Poulami, Marraffini, Luciano A.

“…Type III-A CRISPR-Cas systems defend prokaryotes against viral infection using CRISPR RNA (crRNA)-guided nucleases that perform co-transcriptional cleavage of…”
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Molecular Mechanisms of CRISPR-Cas Immunity in Bacteria by Nussenzweig, Philip M, Marraffini, Luciano A

“…Prokaryotes have developed numerous defense strategies to combat the constant threat posed by the diverse genetic parasites that endanger them. Clustered…”
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An evaluation of the economic effects of bovine respiratory disease on animal performance, carcass traits, and economic outcomes in feedlot cattle defined using four BRD diagnosis methods by Blakebrough-Hall, Claudia, McMeniman, Joe P, González, Luciano A

“…Abstract Bovine respiratory disease (BRD) causes significant economic losses to the feedlot industry due to decreased production and increased costs associated…”
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Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage by Meeske, Alexander J., Nakandakari-Higa, Sandra, Marraffini, Luciano A.

“…Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci in prokaryotes are composed of 30–40-base-pair repeats separated by equally short…”
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RNA-guided editing of bacterial genomes using CRISPR-Cas systems by Jiang, Wenyan, Bikard, David, Cox, David, Zhang, Feng, Marraffini, Luciano A

“…A CRISPR-Cas system is harnessed to introduce template-driven mutations in S. pneumoniae and E. coli at high efficiency without requiring selectable markers…”
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Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity by Samai, Poulami, Pyenson, Nora, Jiang, Wenyan, Goldberg, Gregory W., Hatoum-Aslan, Asma, Marraffini, Luciano A.

“…Immune systems must recognize and destroy different pathogens that threaten the host. CRISPR-Cas immune systems protect prokaryotes from viral and plasmid…”
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CRISPR Interference Can Prevent Natural Transformation and Virulence Acquisition during In Vivo Bacterial Infection by Bikard, David, Hatoum-Aslan, Asma, Mucida, Daniel, Marraffini, Luciano A.

“…Pathogenic bacterial strains emerge largely due to transfer of virulence and antimicrobial resistance genes between bacteria, a process known as horizontal…”
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Diagnosis of atrial fibrillation after stroke and transient ischaemic attack: a systematic review and meta-analysis by Sposato, Luciano A, Dr, Cipriano, Lauren E, PhD, Saposnik, Gustavo, MD, Vargas, Estefanía Ruíz, PhD, Riccio, Patricia M, MD, Hachinski, Vladimir, Prof

“…Summary Background Among patients with atrial fibrillation, the risk of stroke is highest for those with a history of stroke; however, oral anticoagulants can…”
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CRISPR-Cas Systems Optimize Their Immune Response by Specifying the Site of Spacer Integration by McGinn, Jon, Marraffini, Luciano A.

“…CRISPR-Cas systems defend prokaryotes against viruses and plasmids. Short DNA segments of the invader, known as spacers, are stored in the CRISPR array as…”
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CRISPR-Cas: New Tools for Genetic Manipulations from Bacterial Immunity Systems by Jiang, Wenyan, Marraffini, Luciano A

“…Prokaryotic CRISPR-Cas loci encode proteins that function as an adaptive immune system against infectious viruses and plasmids. Immunity is mediated by Cas…”
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CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA by Marraffini, Luciano A, Sontheimer, Erik J

“…Horizontal gene transfer (HGT) in bacteria and archaea occurs through phage transduction, transformation, or conjugation, and the latter is particularly…”
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Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system by Bikard, David, Jiang, Wenyan, Samai, Poulami, Hochschild, Ann, Zhang, Feng, Marraffini, Luciano A

“…The ability to artificially control transcription is essential both to the study of gene function and to the construction of synthetic gene networks with…”
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Mitochondrial cytochrome c oxidase biogenesis: Recent developments by Timón-Gómez, Alba, Nývltová, Eva, Abriata, Luciano A., Vila, Alejandro J., Hosler, Jonathan, Barrientos, Antoni

“…Mitochondrial cytochrome c oxidase (COX) is the primary site of cellular oxygen consumption and is essential for aerobic energy generation in the form of ATP…”
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Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting by Goldberg, Gregory W., Jiang, Wenyan, Bikard, David, Marraffini, Luciano A.

“…The Staphylococcus epidermidis CRISPR-Cas system can prevent lytic infection but tolerate lysogenization by temperate phage through a transcription-dependent…”
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On-barn pig weight estimation based on body measurements by a Kinect v1 depth camera by Pezzuolo, Andrea, Guarino, Marcella, Sartori, Luigi, González, Luciano A., Marinello, Francesco

“…•Manual measurement is traditionally the only way to get indications of animal growth.•A low-cost sensor based on a 3D camera is proposed for pig weight…”
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How Technologies Assisted Science Learning at Home During the COVID-19 Pandemic by Abriata, Luciano A

“…As most other aspects of life, education was strongly affected by the lockdowns imposed to slow down the spread of the COVID-19 pandemic. Teachers at all…”
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Cas9 interaction with the tracrRNA nexus modulates the repression of type II-A CRISPR-cas genes by Kim, Hyejin, Marraffini, Luciano A

“…Immune responses need to be regulated to prevent autoimmunity. CRISPR-Cas systems provide adaptive immunity in prokaryotes through the acquisition of short DNA…”
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