Search Results - "LUBITZ, Steven A"

Detection of Atrial Fibrillation in a Large Population Using Wearable Devices: The Fitbit Heart Study by Lubitz, Steven A., Faranesh, Anthony Z., Selvaggi, Caitlin, Atlas, Steven J., McManus, David D., Singer, Daniel E., Pagoto, Sherry, McConnell, Michael V., Pantelopoulos, Alexandros, Foulkes, Andrea S.

“…Morbidity from undiagnosed atrial fibrillation (AF) may be preventable with early detection. Many consumer wearables contain optical photoplethysmography (PPG)…”
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Population-Based Screening for Atrial Fibrillation by Khurshid, Shaan, Healey, Jeffrey S., McIntyre, William F., Lubitz, Steven A.

“…Atrial fibrillation (AF) is a common and morbid arrhythmia. Stroke is a major hazard of AF and may be preventable with oral anticoagulation. Yet since AF is…”
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ECG-Based Deep Learning and Clinical Risk Factors to Predict Atrial Fibrillation by Khurshid, Shaan, Friedman, Samuel, Reeder, Christopher, Di Achille, Paolo, Diamant, Nathaniel, Singh, Pulkit, Harrington, Lia X., Wang, Xin, Al-Alusi, Mostafa A., Sarma, Gopal, Foulkes, Andrea S., Ellinor, Patrick T., Anderson, Christopher D., Ho, Jennifer E., Philippakis, Anthony A., Batra, Puneet, Lubitz, Steven A.

“…Artificial intelligence (AI)-enabled analysis of 12-lead ECGs may facilitate efficient estimation of incident atrial fibrillation (AF) risk. However, it…”
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Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data from the Framingham Heart Study by Staerk, Laila, Wang, Biqi, Preis, Sarah R, Larson, Martin G, Lubitz, Steven A, Ellinor, Patrick T, McManus, David D, Ko, Darae, Weng, Lu-Chen, Lunetta, Kathryn L, Frost, Lars, Benjamin, Emelia J, Trinquart, Ludovic

“…AbstractObjectiveTo examine the association between risk factor burdens—categorized as optimal, borderline, or elevated—and the lifetime risk of atrial…”
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50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study by Schnabel, Renate B, Dr, Yin, Xiaoyan, PhD, Gona, Philimon, Phd, Larson, Martin G, ScD, Beiser, Alexa S, PhD, McManus, David D, MD, Newton-Cheh, Christopher, MD, Lubitz, Steven A, MD, Magnani, Jared W, MD, Ellinor, Patrick T, MD, Seshadri, Sudha, MD, Wolf, Philip A, MD, Vasan, Ramachandran S, Prof, Benjamin, Emelia J, Prof, Levy, Daniel, Prof

“…Summary Background Comprehensive long-term data on atrial fibrillation trends in men and women are scant. We aimed to provide such data through analysis of the…”
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Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation by Weng, Lu-Chen, Preis, Sarah R, Hulme, Olivia L, Larson, Martin G, Choi, Seung Hoan, Wang, Biqi, Trinquart, Ludovic, McManus, David D, Staerk, Laila, Lin, Honghuang, Lunetta, Kathryn L, Ellinor, Patrick T, Benjamin, Emelia J, Lubitz, Steven A

“…BACKGROUND:The long-term probability of developing atrial fibrillation (AF) considering genetic predisposition and clinical risk factor burden is unknown…”
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Frequency of Cardiac Rhythm Abnormalities in a Half Million Adults by Khurshid, Shaan, Choi, Seung Hoan, Weng, Lu-Chen, Wang, Elizabeth Y, Trinquart, Ludovic, Benjamin, Emelia J, Ellinor, Patrick T, Lubitz, Steven A

“…BACKGROUND:The frequency of cardiac rhythm abnormalities and their risk factors in community-dwelling adults are not well characterized. METHODS:We determined…”
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Rationale and design of a large population study to validate software for the assessment of atrial fibrillation from data acquired by a consumer tracker or smartwatch: The Fitbit heart study by Lubitz, Steven A., Faranesh, Anthony Z., Atlas, Steven J., McManus, David D., Singer, Daniel E., Pagoto, Sherry, Pantelopoulos, Alexandros, Foulkes, Andrea S.

“…[Display omitted] Early detection of atrial fibrillation or flutter (AF) may enable prevention of downstream morbidity. Consumer wrist-worn wearable technology…”
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Sudden Cardiac Arrest Survivorship: A Scientific Statement From the American Heart Association by Sawyer, Kelly N., Camp-Rogers, Teresa R., Kotini-Shah, Pavitra, Del Rios, Marina, Gossip, Michelle R., Moitra, Vivek K., Haywood, Kirstie L., Dougherty, Cynthia M., Lubitz, Steven A., Rabinstein, Alejandro A., Rittenberger, Jon C., Callaway, Clifton W., Abella, Benjamin S., Geocadin, Romergryko G., Kurz, Michael C.

“…Cardiac arrest systems of care are successfully coordinating community, emergency medical services, and hospital efforts to improve the process of care for…”
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Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy by Pirruccello, James P., Bick, Alexander, Wang, Minxian, Chaffin, Mark, Friedman, Samuel, Yao, Jie, Guo, Xiuqing, Venkatesh, Bharath Ambale, Taylor, Kent D., Post, Wendy S., Rich, Stephen, Lima, Joao A. C., Rotter, Jerome I., Philippakis, Anthony, Lubitz, Steven A., Ellinor, Patrick T., Khera, Amit V., Kathiresan, Sekar, Aragam, Krishna G.

“…Dilated cardiomyopathy (DCM) is an important cause of heart failure and the leading indication for heart transplantation. Many rare genetic variants have been…”
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Clinical and genetic evaluation after sudden cardiac arrest by Harris, Stephanie L., Lubitz, Steven A.

“…Sudden cardiac arrest (SCA) and sudden cardiac death (SCD) can be attributed to cardiac, respiratory, metabolic, and toxicologic etiologies. Most cases of SCD…”
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A Functional Variant Associated with Atrial Fibrillation Regulates PITX2c Expression through TFAP2a by Ye, Jiangchuan, Tucker, Nathan R., Weng, Lu-Chen, Clauss, Sebastian, Lubitz, Steven A., Ellinor, Patrick T.

“…The most significantly associated genetic locus for atrial fibrillation (AF) is in chromosomal region 4q25, where four independent association signals have…”
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The Effect of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibition on the Risk of Venous Thromboembolism by Marston, Nicholas A., Gurmu, Yared, Melloni, Giorgio E.M., Bonaca, Marc, Gencer, Baris, Sever, Peter S., Pedersen, Terje R., Keech, Anthony C., Roselli, Carolina, Lubitz, Steven A., Ellinor, Patrick T., O’Donoghue, Michelle L., Giugliano, Robert P., Ruff, Christian T., Sabatine, Marc S.

“…BACKGROUND:The relationship between cholesterol levels and risk of venous thromboembolism (VTE) is uncertain. We set out to determine the effect of PCSK9…”
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Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery by Aragam, Krishna G, Chaffin, Mark, Levinson, Rebecca T, McDermott, Gregory, Choi, Seung Hoan, Shoemaker, M Benjamin, Haas, Mary E, Weng, Lu-Chen, Lindsay, Mark E, Smith, J Gustav, Newton-Cheh, Christopher, Roden, Dan M, London, Barry, Wells, Quinn S, Ellinor, Patrick T, Kathiresan, Sekar, Lubitz, Steven A

“…BACKGROUND:Heart failure (HF) is a morbid and heritable disorder for which the biological mechanisms are incompletely understood. We therefore examined genetic…”
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Cross-modal autoencoder framework learns holistic representations of cardiovascular state by Radhakrishnan, Adityanarayanan, Friedman, Sam F., Khurshid, Shaan, Ng, Kenney, Batra, Puneet, Lubitz, Steven A., Philippakis, Anthony A., Uhler, Caroline

“…A fundamental challenge in diagnostics is integrating multiple modalities to develop a joint characterization of physiological state. Using the heart as a…”
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Genetics of myocardial interstitial fibrosis in the human heart and association with disease by Nauffal, Victor, Di Achille, Paolo, Klarqvist, Marcus D. R., Cunningham, Jonathan W., Hill, Matthew C., Pirruccello, James P., Weng, Lu-Chen, Morrill, Valerie N., Choi, Seung Hoan, Khurshid, Shaan, Friedman, Samuel F., Nekoui, Mahan, Roselli, Carolina, Ng, Kenney, Philippakis, Anthony A., Batra, Puneet, Ellinor, Patrick T., Lubitz, Steven A.

“…Myocardial interstitial fibrosis is associated with cardiovascular disease and adverse prognosis. Here, to investigate the biological pathways that underlie…”
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Adjusting for common variant polygenic scores improves yield in rare variant association analyses by Jurgens, Sean J., Pirruccello, James P., Choi, Seung Hoan, Morrill, Valerie N., Chaffin, Mark, Lubitz, Steven A., Lunetta, Kathryn L., Ellinor, Patrick T.

“…With the emergence of large-scale sequencing data, methods for improving power in rare variant association tests are needed. Here we show that adjusting for…”
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Aspirin Instead of Oral Anticoagulant Prescription in Atrial Fibrillation Patients at Risk for Stroke by Hsu, Jonathan C., MD, MAS, Maddox, Thomas M., MD, MSc, Kennedy, Kevin, MS, Katz, David F., MD, Marzec, Lucas N., MD, Lubitz, Steven A., MD, MPH, Gehi, Anil K., MD, Turakhia, Mintu P., MD, MAS, Marcus, Gregory M., MD, MAS

“…Abstract Background Oral anticoagulation (OAC), rather than aspirin, is recommended in patients with atrial fibrillation (AF) at moderate to high risk of…”
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A comparison of the CHARGE–AF and the CHA2DS2-VASc risk scores for prediction of atrial fibrillation in the Framingham Heart Study by Christophersen, Ingrid E., Yin, Xiaoyan, Larson, Martin G., Lubitz, Steven A., Magnani, Jared W., McManus, David D., Ellinor, Patrick T., Benjamin, Emelia J.

“…Atrial fibrillation (AF) affects more than 33 million individuals worldwide and increases risks of stroke, heart failure, and death. The CHARGE-AF risk score…”
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Galectin 3 and incident atrial fibrillation in the community by Ho, Jennifer E., MD, Yin, Xiaoyan, PhD, Levy, Daniel, MD, Vasan, Ramachandran S., MD, Magnani, Jared W., MD, Ellinor, Patrick T., MD, PhD, McManus, David D., MD, ScM, Lubitz, Steven A., MD, MPH, Larson, Martin G., ScD, Benjamin, Emelia J., MD, ScM

“…Background Galectin 3 (Gal-3) is a potential mediator of cardiac fibrosis, and Gal-3 concentrations predict incident heart failure. The same mechanisms that…”
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