Search Results - "LUBET, Ronald"

Coxibs and other nonsteroidal anti-inflammatory drugs in animal models of cancer chemoprevention by Fischer, Susan M, Hawk, Ernest T, Lubet, Ronald A

“…Coxibs, including celecoxib, and other nonsteroidal anti-inflammatory drugs (NSAID), including aspirin, are among the most promising cancer chemopreventive…”
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PRIMARY PREVENTION AND INTERCEPTION STUDIES IN RAS-MUTATED TUMOR MODELS EMPLOYING SMALL MOLECULES OR VACCINES by Dragnev, Konstantin H, Lubet, Ronald A, Miller, Mark Steven, Sei, Shizuko, Fox, Jennifer T, You, Ming

“…Therapeutic targeting of RAS-mutated cancers is difficult, whereas prevention or interception (treatment before or in the presence of preinvasive lesions)…”
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Targeting Glutamine Metabolism to Enhance Immunoprevention of EGFR‐Driven Lung Cancer by Huang, Mofei, Xiong, Donghai, Pan, Jing, Zhang, Qi, Sei, Shizuko, Shoemaker, Robert H., Lubet, Ronald A., Montuenga, Luis M., Wang, Yian, Slusher, Barbara S., You, Ming

“…Lung cancer is the leading cause of cancer death worldwide. Vaccination against EGFR can be one of the venues to prevent lung cancer. Blocking glutamine…”
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Prediction of molecular targets of cancer preventing flavonoid compounds using computational methods by Chen, Hanyong, Yao, Ke, Nadas, Janos, Bode, Ann M, Malakhova, Margarita, Oi, Naomi, Li, Haitao, Lubet, Ronald A, Dong, Zigang

“…Plant-based polyphenols (i.e., phytochemicals) have been used as treatments for human ailments for centuries. The mechanisms of action of these plant-derived…”
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Multi-Epitope-Based Vaccines for Colon Cancer Treatment and Prevention by Corulli, Lauren R, Cecil, Denise L, Gad, Ekram, Koehnlein, Marlese, Coveler, Andrew L, Childs, Jennifer S, Lubet, Ronald A, Disis, Mary L

“…Overexpression of nonmutated proteins involved in oncogenesis is a mechanism by which such proteins become immunogenic. We questioned whether overexpressed…”
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COX-2 Inhibitors Decrease Expression of PD-L1 in Colon Tumors and Increase the Influx of Type I Tumor-infiltrating Lymphocytes by Cecil, Denise L, Gad, Ekram A, Corulli, Lauren R, Drovetto, Nicholas, Lubet, Ronald A, Disis, Mary L

“…Colon cancer is initiated under inflammatory conditions associated with upregulation of immune checkpoint proteins. We evaluated immune modulation induced by…”
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Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients by Román-Pérez, Erick, Casbas-Hernández, Patricia, Pirone, Jason R, Rein, Jessica, Carey, Lisa A, Lubet, Ronald A, Mani, Sendurai A, Amos, Keith D, Troester, Melissa A

“…A gene expression signature indicative of activated wound responses is common to more than 90% of non-neoplastic tissues adjacent to breast cancer, but these…”
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Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity by Lee, Kyung Mi, Lee, Ki Won, Jung, Sung Keun, Lee, Eun Jung, Heo, Yong-Seok, Bode, Ann M., Lubet, Ronald A., Lee, Hyong Joo, Dong, Zigang

“…Hypothetical computational models of Src in complex with kaempferol. Our results suggest that kaempferol is a potent chemopreventive agent against skin cancer…”
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Quantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [(18)F]ISO-1 by Shoghi, Kooresh I, Xu, Jinbin, Su, Yi, He, June, Rowland, Douglas, Yan, Ying, Garbow, Joel R, Tu, Zhude, Jones, Lynne A, Higashikubo, Ryuji, Wheeler, Kenneth T, Lubet, Ronald A, Mach, Robert H, You, Ming

“…The sigma-2 receptor is expressed in higher density in proliferating (P) tumor cells versus quiescent (Q) tumor cells, thus providing an attractive target for…”
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Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3K by Oi, Naomi, Chen, Hanyong, Ok Kim, Myoung, Lubet, Ronald A, Bode, Ann M, Dong, Zigang

“…Skin cancer is one of the most commonly diagnosed cancers in the United States. Taxifolin reportedly exerts multiple biologic effects, but the molecular…”
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Novel mutational landscapes and expression signatures of lung squamous cell carcinoma by Xiong, Donghai, Pan, Jing, Yin, Yuxin, Jiang, Hui, Szabo, Eva, Lubet, Ronald A, Wang, Yian, You, Ming

“…Lung squamous cell carcinoma (LUSC) is a major subtype of Non-Small Cell Lung Cancer. To increase our understanding of the LUSC pathobiology, we performed…”
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Optimized Bexarotene Aerosol Formulation Inhibits Major Subtypes of Lung Cancer in Mice by Zhang, Qi, Lee, Sang Beom, Chen, Xu, Stevenson, Morgan E, Pan, Jing, Xiong, Donghai, Zhou, Yu, Miller, Mark Steven, Lubet, Ronald A, Wang, Yian, Mirza, Shama P, You, Ming

“…Bexarotene has shown inhibition of lung and mammary gland tumorigenesis in preclinical models and in clinical trials. The main side effects of orally…”
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Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis by Zhang, Qi, Pan, Jing, Wang, Yian, Lubet, Ronald, You, Ming

“…Betanin, also called beetroot red, has been extensively used as a food colorant. In this study, the chemopreventive activity of betanin by oral consumption was…”
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Suppression of Rat Oral Carcinogenesis by Agonists of Peroxisome Proliferator Activated Receptor γ by McCormick, David L, Horn, Thomas L, Johnson, William D, Peng, Xinjian, Lubet, Ronald A, Steele, Vernon E

“…Peroxisome-proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor that regulates cell proliferation, differentiation, and…”
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Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKt inhibitor MK2206 in mammary cancer models by Lubet, Ronald A, Steele, Vernon E, Juliana, M M, Bode, Ann, Moeinpour, Fariba, Grubbs, Clinton J

“…Daily vs. weekly dosing with EGFR inhibitors (gefitinib and lapatinib) and an AKT inhibitor (MK2206) were compared in two rodent breast cancer models. Female…”
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Potentiation of Kras peptide cancer vaccine by avasimibe, a cholesterol modulator by Pan, Jing, Zhang, Qi, Palen, Katie, Wang, Li, Qiao, Lifen, Johnson, Bryon, Sei, Shizuko, Shoemaker, Robert H., Lubet, Ronald A., Wang, Yian, You, Ming

“…No effective approaches to target mutant Kras have yet been developed. Immunoprevention using KRAS-specific antigenic peptides to trigger T cells capable of…”
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Exosomal miRNAs as Novel Pharmacodynamic Biomarkers for Cancer Chemopreventive Agent Early Stage Treatments in Chemically Induced Mouse Model of Lung Squamous Cell Carcinoma by Zhou, Yu, Zhang, Qi, Du, Meijun, Xiong, Donghai, Wang, Yian, Mohammed, Altaf, Lubet, Ronald A, Wang, Liang, You, Ming

“…Chemopreventive agent (CPA) treatment is one of the main preventive options for lung cancer. However, few studies have been done on pharmacodynamic biomarkers…”
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Targeting the insulin-like growth factor-1 receptor by picropodophyllin for lung cancer chemoprevention by Zhang, Qi, Pan, Jing, Lubet, Ronald A., Wang, Yian, You, Ming

“…Insulin‐like growth factor‐1 receptor (IGF‐1R) is a transmembrane heterotetramer that is activated by Insulin‐like growth factor 1 and is crucial for tumor…”
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Immunoprevention of KRAS-driven lung adenocarcinoma by a multipeptide vaccine by Pan, Jing, Zhang, Qi, Sei, Shizuko, Shoemaker, Robert H, Lubet, Ronald A, Wang, Yian, You, Ming

“…Lung cancer remains the leading cause of cancer death worldwide. Mutations in KRAS are detected in up to 30% of lung cancer cases. No effective therapies…”
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Epidermal growth factor receptor derived peptide vaccination to prevent lung adenocarcinoma formation: An in vivo study in a murine model of EGFR mutant lung cancer by Ebben, Johnathan D., Lubet, Ronald A., Gad, Ekram, Disis, Mary L., You, Ming

“…The ability to prevent disease is the holy grail of medicine. For decades, efforts have been made to extend the successes seen with vaccination against…”
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