Search Results - "LOWY, Andrew M"

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring by Shi, Yu, Gao, Weina, Lytle, Nikki K., Huang, Peiwu, Yuan, Xiao, Dann, Amanda M., Ridinger-Saison, Maya, DelGiorno, Kathleen E., Antal, Corina E., Liang, Gaoyang, Atkins, Annette R., Erikson, Galina, Sun, Huaiyu, Meisenhelder, Jill, Terenziani, Elena, Woo, Gyunghwi, Fang, Linjing, Santisakultarm, Thom P., Manor, Uri, Xu, Ruilian, Becerra, Carlos R., Borazanci, Erkut, Von Hoff, Daniel D., Grandgenett, Paul M., Hollingsworth, Michael A., Leblanc, Mathias, Umetsu, Sarah E., Collisson, Eric A., Scadeng, Miriam, Lowy, Andrew M., Donahue, Timothy R., Reya, Tannishtha, Downes, Michael, Evans, Ronald M., Wahl, Geoffrey M., Pawson, Tony, Tian, Ruijun, Hunter, Tony

“…Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic…”
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Borderline resectable pancreatic cancer: Definitions and management by Lopez, Nicole E, Prendergast, Cristina, Lowy, Andrew M

“…Pancreatic cancer is the fourth leading cause of cancer death in the United States. While surgical resection remains the only curative option, more than 80% of…”
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Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness by Zhang, Yijuan, Recouvreux, M Victoria, Jung, Michael, Galenkamp, Koen M O, Li, Yunbo, Zagnitko, Olga, Scott, David A, Lowy, Andrew M, Commisso, Cosimo

“…Although pancreatic ductal adenocarcinoma (PDAC) cells are exposed to a nutrient-depleted tumor microenvironment, they can acquire nutrients via…”
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SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma by Ben-Josef, Edgar, Guthrie, Katherine A, El-Khoueiry, Anthony B, Corless, Christopher L, Zalupski, Mark M, Lowy, Andrew M, Thomas, Jr, Charles R, Alberts, Steven R, Dawson, Laura A, Micetich, Kenneth C, Thomas, Melanie B, Siegel, Abby B, Blanke, Charles D

“…The role of postoperative therapy in extrahepatic cholangiocarcinoma (EHCC) or gallbladder carcinoma (GBCA) is unknown. S0809 was designed to estimate 2-year…”
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Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases by Milette, Simon, Hashimoto, Masakazu, Perrino, Stephanie, Qi, Shu, Chen, Michely, Ham, Boram, Wang, Ni, Istomine, Roman, Lowy, Andrew M., Piccirillo, Ciriaco A., Brodt, Pnina

“…Liver metastases (LM) remain a major cause of cancer-associated death and a clinical challenge. Here we explore a sexual dimorphism observed in the regulation…”
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A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma by Lytle, Nikki K., Ferguson, L. Paige, Rajbhandari, Nirakar, Gilroy, Kathryn, Fox, Raymond G., Deshpande, Anagha, Schürch, Christian M., Hamilton, Michael, Robertson, Neil, Lin, Wei, Noel, Pawan, Wartenberg, Martin, Zlobec, Inti, Eichmann, Micha, Galván, José A., Karamitopoulou, Eva, Gilderman, Tami, Esparza, Lourdes Adriana, Shima, Yutaka, Spahn, Philipp, French, Randall, Lewis, Nathan E., Fisch, Kathleen M., Sasik, Roman, Rosenthal, Sara Brin, Kritzik, Marcie, Von Hoff, Daniel, Han, Haiyong, Ideker, Trey, Deshpande, Aniruddha J., Lowy, Andrew M., Adams, Peter D., Reya, Tannishtha

“…Drug resistance and relapse remain key challenges in pancreatic cancer. Here, we have used RNA sequencing (RNA-seq), chromatin immunoprecipitation (ChIP)-seq,…”
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Development of a predictive model for risk stratification of acute kidney injury in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy by Krause, Martin, Mehdipour, Soraya, Veerapong, Jula, Baumgartner, Joel M., Lowy, Andrew M., Gabriel, Rodney A.

“…Acute kidney injury (AKI) following hyperthermic intraperitoneal chemotherapy (HIPEC) is common. Identifying patients at risk could have implications for…”
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Borderline Resectable Pancreatic Cancer: Need for Standardization and Methods for Optimal Clinical Trial Design by Katz, Matthew H. G., Marsh, Robert, Herman, Joseph M., Shi, Qian, Collison, Eric, Venook, Alan P., Kindler, Hedy L., Alberts, Steven R., Philip, Philip, Lowy, Andrew M., Pisters, Peter W. T., Posner, Mitchell C., Berlin, Jordan D., Ahmad, Syed A.

“…Background Methodological limitations of prior studies have prevented progress in the treatment of patients with borderline resectable pancreatic…”
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Tumor-penetrating therapy for β5 integrin-rich pancreas cancer by Hurtado de Mendoza, Tatiana, Mose, Evangeline S., Botta, Gregory P., Braun, Gary B., Kotamraju, Venkata R., French, Randall P., Suzuki, Kodai, Miyamura, Norio, Teesalu, Tambet, Ruoslahti, Erkki, Lowy, Andrew M., Sugahara, Kazuki N.

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked desmoplasia and drug resistance due, in part, to poor drug delivery to extravascular tumor…”
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Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer by Morton, Jennifer P, Timpson, Paul, Karim, Saadia A, Ridgway, Rachel A, Athineos, Dimitris, Doyle, Brendan, Jamieson, Nigel B, Oien, Karin A, Lowy, Andrew M, Brunton, Valerie G, Frame, Margaret C, Evans, T.R. Jeffry, Sansom, Owen J

“…TP53 mutation occurs in 50-75% of human pancreatic ductal adenocarcinomas (PDAC) following an initiating activating mutation in the KRAS gene. These p53…”
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A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer by Schönhuber, Nina, Seidler, Barbara, Schuck, Kathleen, Veltkamp, Christian, Schachtler, Christina, Zukowska, Magdalena, Eser, Stefan, Feyerabend, Thorsten B, Paul, Mariel C, Eser, Philipp, Klein, Sabine, Lowy, Andrew M, Banerjee, Ruby, Yang, Fangtang, Lee, Chang-Lung, Moding, Everett J, Kirsch, David G, Scheideler, Angelika, Alessi, Dario R, Varela, Ignacio, Bradley, Allan, Kind, Alexander, Schnieke, Angelika E, Rodewald, Hans-Reimer, Rad, Roland, Schmid, Roland M, Schneider, Günter, Saur, Dieter

“…The next generation of genetically engineered mouse models of pancreatic cancer involving a new inducible dual-recombinase system that combines Flp- FRT and…”
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Tumor-penetrating iRGD peptide inhibits metastasis by Sugahara, Kazuki N, Braun, Gary B, de Mendoza, Tatiana Hurtado, Kotamraju, Venkata Ramana, French, Randall P, Lowy, Andrew M, Teesalu, Tambet, Ruoslahti, Erkki

“…Tumor-specific tissue-penetrating peptides deliver drugs into extravascular tumor tissue by increasing tumor vascular permeability through interaction with…”
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Laparoscopy is Safe and Accurate to Evaluate Peritoneal Surface Metastasis Prior to Cytoreductive Surgery by Marmor, Rebecca A., Kelly, Kaitlyn J., Lowy, Andrew M., Baumgartner, Joel M.

“…Background Completeness of cytoreduction is a significant predictor of long-term outcome after cytoreductive surgery (CRS) and hyperthermic intraperitoneal…”
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Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma by Fox, Raymond G., Lytle, Nikki K., Jaquish, Dawn V., Park, Frederick D., Ito, Takahiro, Bajaj, Jeevisha, Koechlein, Claire S., Zimdahl, Bryan, Yano, Masato, Kopp, Janel L., Kritzik, Marcie, Sicklick, Jason K., Sander, Maike, Grandgenett, Paul M., Hollingsworth, Michael A., Shibata, Shinsuke, Pizzo, Donald, Valasek, Mark A., Sasik, Roman, Scadeng, Miriam, Okano, Hideyuki, Kim, Youngsoo, MacLeod, A. Robert, Lowy, Andrew M., Reya, Tannishtha

“…The stem cell determinant Musashi (Msi) is a key mediator of pancreatic cancer progression and therapy resistance. Musashi protein target in pancreatic cancer…”
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GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets by Insel, Paul A, Sriram, Krishna, Wiley, Shu Z, Wilderman, Andrea, Katakia, Trishna, McCann, Thalia, Yokouchi, Hiroshi, Zhang, Lingzhi, Corriden, Ross, Liu, Dongling, Feigin, Michael E, French, Randall P, Lowy, Andrew M, Murray, Fiona

“…G protein-coupled receptors (GPCRs), the largest family of targets for approved drugs, are rarely targeted for cancer treatment, except for certain endocrine…”
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A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer by Fujimura, Ken, Wright, Tracy, Strnadel, Jan, Kaushal, Sharmeela, Metildi, Cristina, Lowy, Andrew M, Bouvet, Michael, Kelber, Jonathan A, Klemke, Richard L

“…Deregulation of protein synthesis is a hallmark of cancer cell proliferation, survival, and metastatic progression. eIF5A1 and its highly related isoform…”
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Combined Modality Treatment of Resectable and Borderline Resectable Pancreas Cancer: Expert Consensus Statement by Abrams, Ross A., Lowy, Andrew M., O’Reilly, Eileen M., Wolff, Robert A., Picozzi, Vincent J., Pisters, Peter W. T.

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Phase I Trial of Stereotactic Body Radiation Therapy Dose Escalation in Pancreatic Cancer by Courtney, P. Travis, Paravati, Anthony J., Atwood, Todd F., Raja, Nandita, Zimmerman, Collin T., Fanta, Paul T., Lowy, Andrew M., Simpson, Daniel R., Xu, Ronghui, Murphy, James D.

“…Stereotactic body radiation therapy (SBRT) has demonstrated encouraging local tumor control rates in the treatment of pancreatic cancer, yet we lack…”
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Sox17 Regulates Organ Lineage Segregation of Ventral Foregut Progenitor Cells by Spence, Jason R., Lange, Alex W., Lin, Suh-Chin J., Kaestner, Klaus H., Lowy, Andrew M., Kim, Injune, Whitsett, Jeffrey A., Wells, James M.

“…The ventral pancreas, biliary system, and liver arise from the posterior ventral foregut, but the cell-intrinsic pathway by which these organ lineages are…”
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Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells by Heinrich, Eileen L, Lee, Wendy, Lu, Jianming, Lowy, Andrew M, Kim, Joseph

“…Previously assumed to be a select ligand for chemokine receptor CXCR4, chemokine CXCL12 is now known to activate both CXCR4 and CXCR7. However, very little is…”
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