Search Results - "LOWENSTEIN, P. R"

Molecular Indetermination in the Transition to Error Catastrophe: Systematic Elimination of Lymphocytic Choriomeningitis Virus through Mutagenesis Does Not Correlate Linearly with Large Increases in Mutant Spectrum Complexity by Grande-Pérez, A., Sierra, S., Castro, M. G., Domingo, E., Lowenstein, P. R.

“…Studies with several RNA viruses have shown that enhanced mutagenesis resulted in decreases of infectivity or virus extinction, as predicted from virus entry…”
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Study of the Efficacy, Biodistribution, and Safety Profile of Therapeutic Gutless Adenovirus Vectors as a Prelude to a Phase I Clinical Trial for Glioblastoma by Muhammad, A K M G, Puntel, M, Candolfi, M, Salem, A, Yagiz, K, Farrokhi, C, Kroeger, K M, Xiong, W, Curtin, J F, Liu, C, Lawrence, K, Bondale, N S, Lerner, J, Baker, G J, Foulad, D, Pechnick, R N, Palmer, D, Ng, P, Lowenstein, P R, Castro, M G

“…Glioblastoma multiforme (GBM) is the most common and most aggressive primary brain tumor in humans. Systemic immunity against gene therapy vectors has been…”
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There Must Be a Way Out of Here: Identifying a Safe and Efficient Combination of Promoter, Transgene, and Vector Backbone for Gene Therapy of Neurological Disease by Lowenstein, PR, Yadav, Viveka Nand, Chockley, Peter, Castro, Maria

“…The long-term therapeutic success of gene therapy for the treatment of neurological diseases will rely in large part on the vector used.1 Clinical success will…”
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Regulatable Gene Expression Systems for Gene Therapy Applications: Progress and Future Challenges by Goverdhana, S, Puntel, M, Xiong, W, Zirger, J M, Barcia, C, Curtin, J F, Soffer, E B, Mondkar, S, King, G D, Hu, J, Sciascia, S A, Candolfi, M, Greengold, D S, Lowenstein, P R, Castro, M G

“…Gene therapy aims to revert diseased phenotypes by the use of both viral and nonviral gene delivery systems. Substantial progress has been made in making gene…”
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Kupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function in vivo by Yang, J, Sanderson, N.S.R, Wawrowsky, K, Puntel, M, Castro, M.G, Lowenstein, P.R

“…To analyze the in vivo structure of antigen-specific immunological synapses during an effective immune response, we established brain tumors expressing the…”
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Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences by Lowenstein, P R, Castro, M G

“…Gene Therapy (2003) 10, 946-954. doi:10.1038/sj.gt.3302048…”
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Efficient Virus Extinction by Combinations of a Mutagen and Antiviral Inhibitors by Pariente, N, Sierra, S, Lowenstein, P R, Domingo, E

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Response of Foot-and-Mouth Disease Virus to Increased Mutagenesis: Influence of Viral Load and Fitness in Loss of Infectivity by Sierra, S, Dávila, M, Lowenstein, P R, Domingo, E

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Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors by Thomas, C E, Schiedner, G, Kochanek, S, Castro, M G, Lowenstein, P R

“…The utility of first-generation adenovirus vectors for long-term gene transfer in humans is limited by preexisting antiadenoviral immunity. We demonstrate here…”
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Current and future strategies for the treatment of malignant brain tumors by Castro, M G, Cowen, R, Williamson, I K, David, A, Jimenez-Dalmaroni, M J, Yuan, X, Bigliari, A, Williams, J C, Hu, J, Lowenstein, P R

“…Glioblastoma (GB) is the most common subtype of primary brain tumor in adults. These tumors are highly invasive, very aggressive, and often infiltrate critical…”
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Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction by Puntel, M, Curtin, J F, Zirger, J M, Muhammad, A K M, Xiong, W, Liu, C, Hu, J, Kroeger, K M, Czer, P, Sciascia, S, Mondkar, S, Lowenstein, P R, Castro, M G

“…First-generation adenoviral (Ad) and high-capacity adenoviral (HC-Ad) vectors are efficient delivery vehicles for transferring therapeutic transgenes in vivo…”
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Viral vectors for gene delivery and gene therapy within the endocrine system by Stone, D, David, A, Bolognani, F, Lowenstein, PR, Castro, MG

“…The transfer of genetic material into endocrine cells and tissues, both in vitro and in vivo, has been identified as critical for the study of endocrine…”
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Virology and immunology of gene therapy, or virology and immunology of high MOI infection with defective viruses by Lowenstein, P R

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Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration by Hurtado-Lorenzo, A, Millan, E, Gonzalez-Nicolini, V, Suwelack, D, Castro, M G, Lowenstein, P R

“…We tested the activity of the dopaminergic neuron differentiation factor sonic hedgehog, its downstream transcription factor target Gli-1, and an orphan…”
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Herpes Simplex Virus Type 1 Thymidine Kinase Sequence Fused to the lacZ Gene Increases Levels of β-Galactosidase Activity per Genome of High-Capacity but Not First-Generation Adenoviral Vectors In Vitro and In Vivo by PUNTEL, M, BARRETT, R. J, SHI, Y, SALEM, A, ZADMEHR, A, HUYNH, P, PALMER, D, NG, P, CASTRO, M. G, LOWENSTEIN, P. R, MONDKAR, S, SAXENA, V, KROEGER, K. M, MUHAMMAD, A. K. M, LIU, C, BONDALE, N, SCIASCIA, S, XIONG, W

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Foot-and-mouth disease virus evolution: exploring pathways towards virus extinction by Domingo, E, Pariente, N, Airaksinen, A, Gonzaĺez-Lopez, C, Sierra, S, Herrera, M, Grande-Pérez, A, Lowenstein, P R, Manrubia, S C, Lázaro, E, Escarmís, C

“…Foot-and-mouth disease virus (FMDV) is genetically and phenotypically variable. As a typical RNA virus, FMDV follows a quasispecies dynamics, with the many…”
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Delivery of sonic hedgehog or glial derived neurotrophic factor to dopamine-rich grafts in a rat model of Parkinson's disease using adenoviral vectors Increased yield of dopamine cells is dependent on embryonic donor age by Torres, E M, Monville, C, Lowenstein, P R, Castro, M G, Dunnett, S B

“…The poor survival of dopamine grafts in Parkinson's disease is one of the main obstacles to the widespread application of this therapy. One hypothesis is that…”
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A novel combination of promoter and enhancers increases transgene expression in vascular smooth muscle cells in vitro and coronary arteries in vivo after adenovirus-mediated gene transfer by APPLEBY, C. E, KINGSTON, P. A, DAVID, A, GERDES, C. A, UMANA, P, CASTRO, M. G, LOWENSTEIN, P. R, HEAGERTY, A. M

“…Recombinant adenoviruses are employed widely for vascular gene transfer. Vascular smooth muscle cells (SMCs) are a relatively poor target for transgene…”
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Immunological needles in the gene therapy haystack: applying a genetic paradigm to gene therapy by Lowenstein, P R

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The Long and Winding Road: From the High-Affinity Choline Uptake Site to Clinical Trials for Malignant Brain Tumors by Lowenstein, P R, Castro, M G

“…Malignant brain tumors are one of the most lethal cancers. They originate from glial cells which infiltrate throughout the brain. Current standard of care…”
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