Search Results - "LOWELL, B. B"

New Neuroscience of Homeostasis and Drives for Food, Water, and Salt by Lowell, Bradford B

“…New neuroscientific techniques have enabled investigators to assess the neurons and pathways involved in essential drives for food, water, and salt and to…”
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Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons by Vong, Linh, Ye, Chianping, Yang, Zongfang, Choi, Brian, Chua, Streamson, Lowell, Bradford B.

“…Leptin acts in the brain to prevent obesity. The underlying neurocircuitry responsible for this is poorly understood, in part because of incomplete knowledge…”
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Identification of Spinal Circuits Transmitting and Gating Mechanical Pain by Duan, Bo, Cheng, Longzhen, Bourane, Steeve, Britz, Olivier, Padilla, Christopher, Garcia-Campmany, Lidia, Krashes, Michael, Knowlton, Wendy, Velasquez, Tomoko, Ren, Xiangyu, Ross, Sarah E., Lowell, Bradford B., Wang, Yun, Goulding, Martyn, Ma, Qiufu

“…Pain information processing in the spinal cord has been postulated to rely on nociceptive transmission (T) neurons receiving inputs from nociceptors and Aβ…”
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Sensory Neurons that Detect Stretch and Nutrients in the Digestive System by Williams, Erika K., Chang, Rui B., Strochlic, David E., Umans, Benjamin D., Lowell, Bradford B., Liberles, Stephen D.

“…Neural inputs from internal organs are essential for normal autonomic function. The vagus nerve is a key body-brain connection that monitors the digestive,…”
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Neuron-type-specific signals for reward and punishment in the ventral tegmental area by Cohen, Jeremiah Y., Haesler, Sebastian, Vong, Linh, Lowell, Bradford B., Uchida, Naoshige

“…Dopaminergic neurons in the mouse ventral tegmental area signal the difference between received and expected reward, whereas GABAergic neurons signal expected…”
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Mitochondrial Dysfunction and Type 2 Diabetes by Lowell, Bradford B, Shulman, Gerald I

“…Maintenance of normal blood glucose levels depends on a complex interplay between the insulin responsiveness of skeletal muscle and liver and…”
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Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward by Al-Hasani, Ream, McCall, Jordan G., Shin, Gunchul, Gomez, Adrian M., Schmitz, Gavin P., Bernardi, Julio M., Pyo, Chang-O., Park, Sung Il, Marcinkiewcz, Catherine M., Crowley, Nicole A., Krashes, Michael J., Lowell, Bradford B., Kash, Thomas L., Rogers, John A., Bruchas, Michael R.

“…The nucleus accumbens (NAc) and the dynorphinergic system are widely implicated in motivated behaviors. Prior studies have shown that activation of…”
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Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome by Kulke, Matthew H, Hörsch, Dieter, Caplin, Martyn E, Anthony, Lowell B, Bergsland, Emily, Öberg, Kjell, Welin, Staffan, Warner, Richard R P, Lombard-Bohas, Catherine, Kunz, Pamela L, Grande, Enrique, Valle, Juan W, Fleming, Douglas, Lapuerta, Pablo, Banks, Phillip, Jackson, Shanna, Zambrowicz, Brian, Sands, Arthur T, Pavel, Marianne

“…Purpose Preliminary studies suggested that telotristat ethyl, a tryptophan hydroxylase inhibitor, reduces bowel movement (BM) frequency in patients with…”
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Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone by Liu, Tiemin, Kong, Dong, Shah, Bhavik P., Ye, Chianping, Koda, Shuichi, Saunders, Arpiar, Ding, Jun B., Yang, Zongfang, Sabatini, Bernardo L., Lowell, Bradford B.

“…AgRP neuron activity drives feeding and weight gain whereas that of nearby POMC neurons does the opposite. However, the role of excitatory glutamatergic input…”
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Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons by Sohn, Jong-Woo, Harris, Louise E., Berglund, Eric D., Liu, Tiemin, Vong, Linh, Lowell, Bradford B., Balthasar, Nina, Williams, Kevin W., Elmquist, Joel K.

“…Melanocortin 4 receptors (MC4Rs) in the central nervous system are key regulators of energy and glucose homeostasis. Notably, obese patients with MC4R…”
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Estimation of Current and Future Physiological States in Insular Cortex by Livneh, Yoav, Sugden, Arthur U., Madara, Joseph C., Essner, Rachel A., Flores, Vanessa I., Sugden, Lauren A., Resch, Jon M., Lowell, Bradford B., Andermann, Mark L.

“…Interoception, the sense of internal bodily signals, is essential for physiological homeostasis, cognition, and emotions. While human insular cortex (InsCtx)…”
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Identification of spinal circuits involved in touch-evoked dynamic mechanical pain by Cheng, Longzhen, Duan, Bo, Huang, Tianwen, Zhang, Yan, Chen, Yangyang, Britz, Olivier, Garcia-Campmany, Lidia, Ren, Xiangyu, Vong, Linh, Lowell, Bradford B, Goulding, Martyn, Wang, Yun, Ma, Qiufu

“…Touch-evoked dynamic mechanical pain is one of most bothersome and prevalent symptoms in chronic pain patients. Here the authors have genetically identified a…”
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Telotristat ethyl in carcinoid syndrome: safety and efficacy in the TELECAST phase 3 trial by Pavel, Marianne, Gross, David J, Benavent, Marta, Perros, Petros, Srirajaskanthan, Raj, Warner, Richard R P, Kulke, Matthew H, Anthony, Lowell B, Kunz, Pamela L, Hörsch, Dieter, Weickert, Martin O, Lapuerta, Pablo, Jiang, Wenjun, Kassler-Taub, Kenneth, Wason, Suman, Fleming, Rosanna, Fleming, Douglas, Garcia-Carbonero, Rocio

“…Telotristat ethyl, a tryptophan hydroxylase inhibitor, was efficacious and well tolerated in the phase 3 TELESTAR study in patients with carcinoid syndrome…”
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Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP by Krashes, Michael J., Shah, Bhavik P., Koda, Shuichi, Lowell, Bradford B.

“…Agouti-related peptide (AgRP) neurons of the hypothalamus release a fast transmitter (GABA) in addition to neuropeptides (neuropeptide Y [NPY] and…”
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Homeostatic circuits selectively gate food cue responses in insular cortex by Livneh, Yoav, Ramesh, Rohan N., Burgess, Christian R., Levandowski, Kirsten M., Madara, Joseph C., Fenselau, Henning, Goldey, Glenn J., Diaz, Veronica E., Jikomes, Nick, Resch, Jon M., Lowell, Bradford B., Andermann, Mark L.

“…Physiological needs bias perception and attention to relevant sensory cues. This process is ‘hijacked’ by drug addiction, causing cue-induced cravings and…”
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Rapid, reversible activation of AgRP neurons drives feeding behavior in mice by Krashes, Michael J, Koda, Shuichi, Ye, ChianPing, Rogan, Sarah C, Adams, Andrew C, Cusher, Daniel S, Maratos-Flier, Eleftheria, Roth, Bryan L, Lowell, Bradford B

“…Several different neuronal populations are involved in regulating energy homeostasis. Among these, agouti-related protein (AgRP) neurons are thought to promote…”
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Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism by BOSS, O, HAGEN, T, LOWELL, B. B

“…Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism. O Boss , T Hagen and B B Lowell Department of Medicine, Beth Israel…”
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A neural basis for melanocortin-4 receptor–regulated appetite by Garfield, Alastair S, Li, Chia, Madara, Joseph C, Shah, Bhavik P, Webber, Emily, Steger, Jennifer S, Campbell, John N, Gavrilova, Oksana, Lee, Charlotte E, Olson, David P, Elmquist, Joel K, Tannous, Bakhos A, Krashes, Michael J, Lowell, Bradford B

“…Melanocortin 4 receptors (MC4Rs) are critical to the promotion of homeostatic satiety. The authors established paraventricular hypothalamus (PVH)…”
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An obligate role of oxytocin neurons in diet induced energy expenditure by Wu, Zhaofei, Xu, Yuanzhong, Zhu, Yaming, Sutton, Amy K, Zhao, Rongjie, Lowell, Bradford B, Olson, David P, Tong, Qingchun

“…Oxytocin neurons represent one of the major subsets of neurons in the paraventricular hypothalamus (PVH), a critical brain region for energy homeostasis…”
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Runx1 controls terminal morphology and mechanosensitivity of VGLUT3-expressing C-mechanoreceptors by Lou, Shan, Duan, Bo, Vong, Linh, Lowell, Bradford B, Ma, Qiufu

“…VGLUT3-expressing unmyelinated low-threshold mechanoreceptors (C-LTMRs) are proposed to mediate pleasant touch and/or pain, but the molecular programs…”
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