Search Results - "LOWDELL, M. W."

The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro by STEELE, A. J, JONES, D. T, HOFFBRAND, A. V, WICKREMASINGHE, R. G, GANESHAGURU, K, DUKE, V. M, YOGASHANGARY, B. C, NORTH, J. M, LOWDELL, M. W, KOTTARIDIS, P. D, MEHTA, A. B, PRENTICE, A. G

“…We have studied the in vitro actions of the sesquiterpene lactone parthenolide (PTL) on cells isolated from patients with chronic lymphocytic leukemia (CLL)…”
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Tissue‐Engineered Tracheal Replacement in a Child: A 4‐Year Follow‐Up Study by Hamilton, N. J., Kanani, M., Roebuck, D. J., Hewitt, R. J., Cetto, R., Culme‐Seymour, E. J., Toll, E., Bates, A. J., Comerford, A. P., McLaren, C. A., Butler, C. R., Crowley, C., McIntyre, D., Sebire, N. J., Janes, S. M., O'Callaghan, C., Mason, C., De Coppi, P., Lowdell, M. W., Elliott, M. J., Birchall, M. A.

“…In 2010, a tissue‐engineered trachea was transplanted into a 10‐year‐old child using a decellularized deceased donor trachea repopulated with the recipient's…”
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Acute myeloid leukaemia cells secrete a soluble factor that inhibits T and NK cell proliferation but not cytolytic function – implications for the adoptive immunotherapy of leukaemia by Orleans‐Lindsay, J. K., Barber, L. D., Prentice, H. G., Lowdell, M. W.

“…Evidence of an immune mediated graft‐versus‐leukaemia effect has led to the belief that T and NK cell based adoptive immunotherapy can constitute effective…”
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Biochemical changes caused by decellularization may compromise mechanical integrity of tracheal scaffolds by Partington, L., Mordan, N.J., Mason, C., Knowles, J.C., Kim, H-W., Lowdell, M.W., Birchall, M.A., Wall, I.B.

“…Tissue-engineered airways have achieved clinical success, but concerns remain about short-term loss of biomechanical properties, necessitating a stent. This…”
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Functional impairment of human T-lymphocytes following PHA-induced expansion and retroviral transduction: implications for gene therapy by DUARTE, R. F, CHEN, F. E, LOWDELL, M. W, POTTER, M. N, LAMANA, M. L, PRENTICE, H. G, MADRIGAL, J. A

“…The immune function of retrovirus-mediated gene modified (GM) T cells is critical for a beneficial effect to follow their adoptive transfer into patients…”
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Selective removal of alloreactive cells from haematopoietic stem cell grafts : graft engineering for GVHD prophylaxis by KOH, M. B. C, PRENTICE, H. G, LOWDELL, M. W

“…One of the main goals in allogeneic bone marrow transplantation is the abrogation of graft-versus-host disease with the preservation of antileukaemia and…”
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Pilot study of a novel vacuum‐assisted method for decellularization of tracheae for clinical tissue engineering applications by Lange, P., Greco, K., Partington, L., Carvalho, C., Oliani, S., Birchall, M. A., Sibbons, P. D., Lowdell, M. W., Ansari, T.

“…Tissue engineered tracheae have been successfully implanted to treat a small number of patients on compassionate grounds. The treatment has not become…”
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ANALYSIS OF APOPTOSIS IN RELATION TO TISSUE DESTRUCTION ASSOCIATED WITH HASHIMOTO'S AUTOIMMUNE THYROIDITIS by HAMMOND, L. J., LOWDELL, M. W., CERRANO, P. G., GOODE, A. W., BOTTAZZO, G. F., MIRAKIAN, R.

“…The level of apoptosis has been investigated in thyroid tissue from eight patients with Graves's disease, one with Hashitoxicosis, three with Hashimoto's…”
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Intracoronary platelet and monocyte activation status within platelet-monocyte complexes are determinants of inflammation in ST elevation myocardial infarction1 by Majumder, B, Koganti, S, Lowdell, M W, Rakhit, R D

“…Platelet Monocyte Complexes (PMCs) are commonly expressed in coronary artery disease but their pathologic significance in ST elevation myocardial infarction…”
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Generation of memory T cells for adoptive transfer using clinical-grade anti-CD62L magnetic beads by Verfuerth, S, Sousa, P S E, Beloki, L, Murray, M, Peters, M D, Mackinnon, S, Lowdell, M W, Chakraverty, R, Samuel, E R

“…Pre-clinical studies of allogeneic stem cell transplantation suggest that depletion of naive T cells from donor lymphocytes will reduce the risk of GvHD but…”
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In vitro co‐stimulation with anti‐CD28 synergizes with IL‐12 in the generation of T cell immune responses to leukaemic cells; a strategy for ex‐vivo generation of CTL for immunotherapy by ORLEANS‐LINDSAY, J. K., DERU, A., CRAIG, J. I. O., PRENTICE, H. G., LOWDELL, M. W.

“…SUMMARY The existence of an immune based graft‐versus‐leukaemia (GvL) effect highlighted the prospect of managing relapsed leukaemias with T cell‐based…”
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Natural killer cells in haematopoietic stem cell transplantation by Lowdell, M. W.

“…Natural killer cells represent the predominant lymphoid cell in the peripheral blood for many months after allogeneic or autologous stem cell transplant and…”
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Generation of memory T cells for adoptive transfer using clinical-grade anti-CD62L magnetic beads by Verfuerth, S, Sousa, P S E, Beloki, L, Murray, M, Peters, M D, O'Neill, A T, Mackinnon, S, Lowdell, M W, Chakraverty, R, Samuel, E R

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The effect of T cell depletion with Campath-1M on immune reconstitution after chemotherapy and allogeneic bone marrow transplant as treatment for leukaemia by LOWDELL, M. W, CRASTON, R, RAY, N, KOH, M, GALATOWICZ, G, PRENTICE, H. G

“…The prophylactic use of T cell depletion (TCD) strategies for the prevention of graft-versus-host disease (GVHD) following allogeneic stem cell transplantation…”
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Reply to: “Recent Advances in Circumferential Tracheal Replacement and Transplantation” by Hamilton, N. J., Kanani, M., Roebuck, D. J., Hewitt, R. J., Cetto, R., McLaren, C. A., Butler, C. R., Crowley, C., Janes, S. M., O'Callaghan, C., Culme‐Seymour, E. J., Mason, C., De Coppi, P., Lowdell, M. W., Elliott, M. J., Birchall, M. A.

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Temporal dynamics of CD69 expression on lymphoid cells by Craston, R, Koh, M, Mc Dermott, A, Ray, N, Prentice, H.G, Lowdell, M.W

“…Lymphocyte activation remains an area of intense interest to immunologists and cell biologists and the dynamics of expression of surface molecules during the…”
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Tissue banking in ENT: challenges and methods by Warner, E, Birchall, M, Lowdell, M W

“…Biobanking is the process of storing high quality human biospecimens alongside linked clinical data, for research purposes. The aim is to identify novel…”
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Non‐MHC‐restricted cytotoxic cells: their roles in the control and treatment of leukaemias by Lowdell, Mark W., Lamb, Lawrence, Hoyle, Christine, Velardi, Andrea, Prentice, H. Grant

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The in vitro detection of anti-leukaemia-specific cytotoxicity after autologous bone marrow transplantation for acute leukaemia by LOWDELL, M. W, RAY, N, CRASTON, R, CORBETT, T, DEANE, M, PRENTICE, H. G

“…Anti-leukaemia activity after allogeneic bone marrow transplantation has been studied extensively but its antigen specificity and effector cell phenotype…”
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Quality issues in stem cell and immunotherapy laboratories by Smith, L., Lowdell, M. W.

“…The advent of the Code of Practice for Tissue Banks has led to the requirement for quality systems to be established in all laboratories involved in the…”
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