Search Results - "LOW, Philip S"

Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases by Low, Philip S, Henne, Walter A, Doorneweerd, Derek D

“…In order to avoid the toxicities associated with prescription drug use today, we have explored novel methods for delivering drugs selectively to pathologic…”
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Tumor detection using folate receptor-targeted imaging agents by Sega, Emanuela I., Low, Philip S.

“…Folate receptors are up-regulated on a variety of human cancers, including cancers of the breast, ovaries, endometrium, lungs, kidneys, colon, brain, and…”
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A phase II, multicenter, open-label trial of OTL38 injection for the intra-operative imaging of folate receptor-alpha positive ovarian cancer by Randall, Leslie M., Wenham, Robert M., Low, Philip S., Dowdy, Sean C., Tanyi, Janos L.

“…OTL38 is a folate-indole-cyanine green-like conjugate to folate receptor alpha (FRa). The objectives of this prospective trial were to assess the safety and…”
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Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters by Lee, Yong Gu, Chu, Haiyan, Lu, Yingjuan, Leamon, Christopher P., Srinivasarao, Madduri, Putt, Karson S., Low, Philip S.

“…Although chimeric antigen receptor (CAR) T cell therapies have demonstrated considerable success in treating hematologic malignancies, they have simultaneously…”
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Evaluation of Novel Tumor-Targeted Near-Infrared Probe for Fluorescence-Guided Surgery of Cancer by Mahalingam, Sakkarapalayam M, Kularatne, Sumith A, Myers, Carrie H, Gagare, Pravin, Norshi, Mohammad, Liu, Xin, Singhal, Sunil, Low, Philip S

“…Because the most reliable therapy for cancer involves quantitative resection of all diseased tissue, considerable effort has been devoted to improving a…”
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Oxygen regulates the band 3-ankyrin bridge in the human erythrocyte membrane by Stefanovic, Marko, Puchulu-Campanella, Estela, Kodippili, Gayani, Low, Philip S

“…The oxygenation state of erythrocytes is known to impact several cellular processes. As the only known O2-binding protein in red blood cells, haemoglobin has…”
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Intraoperative fluorescence imaging in thoracic surgery by Newton, Andrew D., Predina, Jarrod D., Nie, Shuming, Low, Philip S., Singhal, Sunil

“…Intraoperative fluorescence imaging (IFI) can improve real‐time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery…”
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Mapping of glycolytic enzyme-binding sites on human erythrocyte band 3 by Chu, Haiyan, Low, Philip S

“…Previous work has shown that GAPDH (glyceraldehyde-3-phosphate dehydrogenase), aldolase, PFK (phosphofructokinase), PK (pyruvate kinase) and LDH (lactate…”
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A Phase I Clinical Trial of Targeted Intraoperative Molecular Imaging for Pulmonary Adenocarcinomas by Predina, Jarrod D., Newton, Andrew D., Keating, Jane, Dunbar, Ashley, Connolly, Courtney, Baldassari, Michael, Mizelle, Jack, Xia, Leilei, Deshpande, Charuhas, Kucharczuk, John, Low, Philip S., Singhal, Sunil

“…Intraoperative identification of pulmonary nodules, particularly small lesions, can be challenging. We hypothesize that folate receptor-targeted intraoperative…”
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Folate receptor-mediated drug targeting: from therapeutics to diagnostics by Hilgenbrink, Andrew R, Low, Philip S

“…Folate targeted drug delivery has emerged as an alternative therapy for the treatment and imaging of many cancers and inflammatory diseases. Due to its small…”
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Regulation of membrane-cytoskeletal interactions by tyrosine phosphorylation of erythrocyte band 3 by Ferru, Emanuela, Giger, Katie, Pantaleo, Antonella, Campanella, Estela, Grey, Jesse, Ritchie, Ken, Vono, Rosa, Turrini, Francesco, Low, Philip S.

“…The cytoplasmic domain of band 3 serves as a center of erythrocyte membrane organization and constitutes the major substrate of erythrocyte tyrosine kinases…”
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Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases by Frigerio, Barbara, Bizzoni, Claudia, Jansen, Gerrit, Leamon, Christopher P, Peters, Godefridus J, Low, Philip S, Matherly, Larry H, Figini, Mariangela

“…Folate receptors and transporters and one-carbon metabolism continue to be important areas of study given their essential roles in an assortment of diseases…”
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Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models by Hettiarachchi, Suraj U, Li, Yen-Hsing, Roy, Jyoti, Zhang, Fenghua, Puchulu-Campanella, Estela, Lindeman, Spencer D, Srinivasarao, Madduri, Tsoyi, Konstantin, Liang, Xiaoliang, Ayaub, Ehab A, Nickerson-Nutter, Cheryl, Rosas, Ivan O, Low, Philip S

“…Idiopathic pulmonary fibrosis (IPF) is a lethal disease with an average life expectancy of 3 to 5 years. IPF is characterized by progressive stiffening of the…”
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Targeting of a Photosensitizer to the Mitochondrion Enhances the Potency of Photodynamic Therapy by Mahalingam, Sakkarapalayam M, Ordaz, Josue D, Low, Philip S

“…Photodynamic therapy (PDT) involves use of a photosensitizer, whose activation with light leads to the production of singlet oxygen (SOS), generation of…”
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FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer by Orellana, Esteban A, Tenneti, Srinivasarao, Rangasamy, Loganathan, Lyle, L Tiffany, Low, Philip S, Kasinski, Andrea L

“…MicroRNAs are small RNAs that negatively regulate gene expression posttranscriptionally. Because changes in microRNA expression can promote or maintain disease…”
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Fast Release of Lipophilic Agents from Circulating PEG-PDLLA Micelles Revealed by in Vivo Förster Resonance Energy Transfer Imaging by HONGTAO CHEN, KIM, Sungwon, WEI HE, HAIFENG WAN, LOW, Philip S, PARK, Kinam, CHENG, Ji-Xin

“…Understanding the in vivo behavior of nanoparticles is critical for the translation of nanomedicine from laboratory research to clinical trials. In this work,…”
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Identification of tyrosine kinase inhibitors that halt Plasmodium falciparum parasitemia by Kesely, Kristina, Noomuna, Panae, Vieth, Michal, Hipskind, Philip, Haldar, Kasturi, Pantaleo, Antonella, Turrini, Francesco, Low, Philip S

“…Although current malaria therapies inhibit pathways encoded in the parasite's genome, we have looked for anti-malaria drugs that can target an erythrocyte…”
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A universal dual mechanism immunotherapy for the treatment of influenza virus infections by Liu, Xin, Zhang, Boning, Wang, Yingcai, Haymour, Hanan S., Zhang, Fenghua, Xu, Le-cun, Srinivasarao, Madduri, Low, Philip S.

“…Seasonal influenza epidemics lead to 3–5 million severe infections and 290,000–650,000 annual global deaths. With deaths from the 1918 influenza pandemic…”
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Identification of a Folate Receptor-Targeted Near-Infrared Molecular Contrast Agent to Localize Pulmonary Adenocarcinomas by Predina, Jarrod D., Newton, Andrew D., Connolly, Courtney, Dunbar, Ashley, Baldassari, Michael, Deshpande, Charuhas, Cantu, Edward, Stadanlick, Jason, Kularatne, Sumith A., Low, Philip S., Singhal, Sunil

“…Non-small cell lung cancer (NSCLC) is the number one cancer killer in the United States. Despite attempted curative surgical resection, nearly 40% of patients…”
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Macrophage Hitchhiking Nanoparticles for the Treatment of Myocardial Infarction: An In Vitro and In Vivo Study by Torrieri, Giulia, Iqbal, Imran, Fontana, Flavia, Talman, Virpi, Liljenbäck, Heidi, Putri, Andriana, Nammas, Wail, Rajander, Johan, Guo‐Li, Xiang, Low, Philip S., Teesalu, Tambet, Roivainen, Anne, Hirvonen, Jouni, Ruskoaho, Heikki, Balasubramanian, Vimalkumar, Saraste, Antti, Santos, Hélder A.

“…Myocardial infarction (MI) is the leading cause of death worldwide. However, current therapies are unable to restore the function of the injured myocardium…”
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