Search Results - "LOW, Lindsey"

Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase by Petković, Hrvoje, Sandmann, Axel, Challis, Iain R, Hecht, Hans-Jürgen, Silakowski, Barbara, Low, Lindsey, Beeston, Nicola, Kuscer, Enej, Garcia-Bernardo, Jose, Leadlay, Peter F, Kendrew, Steven G, Wilkinson, Barrie, Müller, Rolf

“…The production of epothilone mixtures is a direct consequence of the substrate tolerance of the module 3 acyltransferase (AT) domain of the epothilone…”
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Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties by Schell, Ursula, Haydock, Stephen F, Kaja, Andrew L, Carletti, Isabelle, Lill, Rachel E, Read, Eliot, Sheehan, Lesley S, Low, Lindsey, Fernandez, Maria-Jose, Grolle, Friederike, McArthur, Hamish A I, Sheridan, Rose M, Leadlay, Peter F, Wilkinson, Barrie, Gaisser, Sabine

“…The glycosylation of natural product scaffolds with highly modified deoxysugars is often essential for their biological activity, being responsible for…”
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Rapamycin biosynthesis: Elucidation of gene product function by Gregory, Matthew A, Hong, Hui, Lill, Rachel E, Gaisser, Sabine, Petkovic, Hrvoje, Low, Lindsey, Sheehan, Lesley S, Carletti, Isabelle, Ready, Sarah J, Ward, Michael J, Kaja, Andrew L, Weston, Alison J, Challis, Iain R, Leadlay, Peter F, Martin, Christine J, Wilkinson, Barrie, Sheridan, Rose M

“…The function of gene products involved in the biosynthesis of the clinically important polyketide rapamycin were elucidated by biotransformation and gene…”
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DNA vaccination with electroporation induces increased antibody responses in patients with prostate cancer by Low, Lindsey, Mander, Ann, McCann, Katy, Dearnaley, David, Tjelle, Torunn, Mathiesen, Iacob, Stevenson, Freda, Ottensmeier, Christian H

“…We are evaluating the use of electroporation (EP) to deliver a novel DNA vaccine, p.DOM-PSMA(27). This vaccine encodes a domain (DOM) of fragment C of tetanus…”
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Fit for purpose? A case study: validation of immunological endpoint assays for the detection of cellular and humoral responses to anti-tumour DNA fusion vaccines by Mander, Ann, Chowdhury, Ferdousi, Low, Lindsey, Ottensmeier, Christian H

“…Clinical trials are governed by an increasingly stringent regulatory framework, which applies to all levels of trial conduct. Study critical immunological…”
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Active-site residue, domain and module swaps in modular polyketide synthases by DEL VECCHIO, Francesca, PETKOVIC, Hrvoje, KENDREW, Steven G, LOW, Lindsey, WILKINSON, Barrie, LILL, Rachel, CORTES, Jesus, RUDD, Brian A. M, STAUNTON, Jim, LEADLAY, Peter F

“…Sequence comparisons of multiple acyltransferase (AT) domains from modular polyketide synthases (PKSs) have highlighted a correlation between a short sequence…”
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Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272 by Gaisser, Sabine, Kellenberger, Laurenz, Kaja, Andrew L, Weston, Alison J, Lill, Rachel E, Wirtz, Gabriele, Kendrew, Steven G, Low, Lindsey, Sheridan, Rose M, Wilkinson, Barrie, Galloway, Ian S, Stutzman-Engwall, Kim, McArthur, Hamish A, Staunton, James, Leadlay, Peter F

“…Ivermectin, a mixture of 22,23-dihydroavermectin B1a9 with minor amounts of 22,23-dihydroavermectin B1b 10, is one of the most successful veterinary…”
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