Search Results - "LOVETT, Jacqueline"

Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression by Farmer, Cristan A, Gilbert, Jessica R, Moaddel, Ruin, George, Jomy, Adeojo, Lilian, Lovett, Jacqueline, Nugent, Allison C, Kadriu, Bashkim, Yuan, Peixiong, Gould, Todd D, Park, Lawrence T, Zarate, Jr, Carlos A

“…A single, subanesthetic dose of (R,S)-ketamine (ketamine) exerts rapid and robust antidepressant effects. Several groups previously reported that…”
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Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects by Moaddel, Ruin, Shardell, Michelle, Khadeer, Mohammed, Lovett, Jacqueline, Kadriu, Bashkim, Ravichandran, Sarangan, Morris, Patrick J., Yuan, Peixiong, Thomas, Craig J., Gould, Todd D., Ferrucci, Luigi, Zarate, Carlos A.

“…(R,S)-Ketamine produces rapid, robust, and sustained antidepressant effects in major depressive disorder. Specifically, its pharmacological efficacy in…”
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Cross-sectional analysis of plasma and CSF metabolomic markers in Huntington’s disease for participants of varying functional disability: a pilot study by McGarry, Andrew, Gaughan, John, Hackmyer, Cory, Lovett, Jacqueline, Khadeer, Mohammed, Shaikh, Hamza, Pradhan, Basant, Ferraro, Thomas N., Wainer, Irving W., Moaddel, Ruin

“…Huntington’s Disease (HD) is a progressive, fatal neurodegenerative condition. While generally considered for its devastating neurological phenotype,…”
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Temporal changes in sphingolipids and systemic insulin sensitivity during the transition from gestation to lactation by Rico, J Eduardo, Saed Samii, Sina, Mathews, Alice T, Lovett, Jacqueline, Haughey, Norman J, McFadden, Joseph W

“…Reduced insulin action develops naturally during the peripartum to ensure maternal nutrient delivery to the fetus and neonate. However, increased insulin…”
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Kynurenines link chronic inflammation to functional decline and physical frailty by Westbrook, Reyhan, Chung, Tae, Lovett, Jacqueline, Ward, Chris, Joca, Humberto, Yang, Huanle, Khadeer, Mohammed, Tian, Jing, Xue, Qian-Li, Le, Anne, Ferrucci, Luigi, Moaddel, Ruin, de Cabo, Rafa, Hoke, Ahmet, Walston, Jeremy, Abadir, Peter M

“…Chronic inflammation is associated with physical frailty and functional decline in older adults; however, the molecular mechanisms of this linkage are not…”
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Dynamics of autochthonous soil viral communities parallels dynamics of host communities under nutrient stimulation by Srinivasiah, Sharath, Lovett, Jacqueline, Ghosh, Dhritiman, Roy, Krishnakali, Fuhrmann, Jeffry J., Radosevich, Mark, Wommack, K. Eric

“…Viruses are highly abundant in soils with their numbers exceeding those of cooccurring bacterial cells by 10- to over 1000-fold. Water and organic matter…”
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Author Correction: Cross-sectional analysis of plasma and CSF metabolomic markers in Huntington’s disease for participants of varying functional disability: a pilot study by McGarry, Andrew, Gaughan, John, Hackmyer, Cory, Lovett, Jacqueline, Khadeer, Mohammed, Shaikh, Hamza, Pradhan, Basant, Ferraro, Thomas N., Wainer, Irving W., Moaddel, Ruin

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administration by Moaddel, Ruin, Zanos, Panos, Farmer, Cristan A., Kadriu, Bashkim, Morris, Patrick J., Lovett, Jacqueline, Acevedo-Diaz, Elia E., Cavanaugh, Grace W., Yuan, Peixiong, Yavi, Mani, Thomas, Craig J., Park, Lawrence T., Ferrucci, Luigi, Gould, Todd D., Zarate, Carlos A.

“…Subanesthetic-dose racemic ( R,S )-ketamine (ketamine) produces rapid, robust, and sustained antidepressant effects in major depressive disorder (MDD) and…”
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Direct Assessment of Viral Diversity in Soils by Random PCR Amplification of Polymorphic DNA by SRINIVASIAH, Sharath, LOVETT, Jacqueline, POLSON, Shawn, BHAVSAR, Jaysheel, GHOSH, Dhritiman, ROY, Krishnakali, FUHRMANN, Jeffry J, RADOSEVICH, Mark, WOMMACK, K. Eric

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Short-term responses of decomposers to flow restoration in Fossil Creek, Arizona, USA by Muehlbauer, Jeffrey D, LeRoy, Carri J, Lovett, Jacqueline M, Flaccus, Kathleen K, Vlieg, Julie K, Marks, Jane C

“…Dam decommissioning projects, although numerous, rarely include complete sets of data before and after restoration for evaluating the ecological consequences…”
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(R)‐Ketamine exerts antidepressant actions partly via conversion to (2R,6R)‐hydroxynorketamine, while causing adverse effects at sub‐anaesthetic doses by Zanos, Panos, Highland, Jaclyn N., Liu, Xin, Troppoli, Timothy A., Georgiou, Polymnia, Lovett, Jacqueline, Morris, Patrick J., Stewart, Brent W., Thomas, Craig J., Thompson, Scott M., Moaddel, Ruin, Gould, Todd D.

“…Background and Purpose (R)‐Ketamine (arketamine) may have utility as a rapidly acting antidepressant. While (R)‐ketamine has lower potency than (R,S)‐ketamine…”
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Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin by Vreones, Michael, Mustapic, Maja, Moaddel, Ruin, Pucha, Krishna A., Lovett, Jacqueline, Seals, Douglas R., Kapogiannis, Dimitrios, Martens, Christopher R.

“…Declining nicotinamide adenine dinucleotide (NAD+) concentration in the brain during aging contributes to metabolic and cellular dysfunction and is implicated…”
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Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor by Georgiou, Polymnia, Zanos, Panos, Mou, Ta-Chung M., An, Xiaoxian, Gerhard, Danielle M., Dryanovski, Dilyan I., Potter, Liam E., Highland, Jaclyn N., Jenne, Carleigh E., Stewart, Brent W., Pultorak, Katherine J., Yuan, Peixiong, Powels, Chris F., Lovett, Jacqueline, Pereira, Edna F. R., Clark, Sarah M., Tonelli, Leonardo H., Moaddel, Ruin, Zarate, Carlos A., Duman, Ronald S., Thompson, Scott M., Gould, Todd D.

“…We show that the sex of human experimenters affects mouse behaviors and responses following administration of the rapid-acting antidepressant ketamine and its…”
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Cross-Laboratory Standardization of Preclinical Lipidomics Using Differential Mobility Spectrometry and Multiple Reaction Monitoring by Ghorasaini, Mohan, Mohammed, Yassene, Adamski, Jerzy, Bettcher, Lisa, Bowden, John A, Cabruja, Matias, Contrepois, Kévin, Ellenberger, Mathew, Gajera, Bharat, Haid, Mark, Hornburg, Daniel, Hunter, Christie, Jones, Christina M, Klein, Theo, Mayboroda, Oleg, Mirzaian, Mina, Moaddel, Ruin, Ferrucci, Luigi, Lovett, Jacqueline, Nazir, Kenneth, Pearson, Mackenzie, Ubhi, Baljit K, Raftery, Daniel, Riols, Fabien, Sayers, Rebekah, Sijbrands, Eric J. G, Snyder, Michael P, Su, Baolong, Velagapudi, Vidya, Williams, Kevin J, de Rijke, Yolanda B, Giera, Martin

“…Modern biomarker and translational research as well as personalized health care studies rely heavily on powerful omics’ technologies, including metabolomics…”
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Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function by Lumsden, Eric W., Troppoli, Timothy A., Myers, Scott J., Zanos, Panos, Aracava, Yasco, Kehr, Jan, Lovett, Jacqueline, Kim, Sukhan, Wang, Fu-Hua, Schmidt, Staffan, Jenne, Carleigh E., Yuan, Peixiong, Morris, Patrick J., Thomas, Craig J., Zarate, Carlos A., Moaddel, Ruin, Traynelis, Stephen F., Pereira, Edna F. R., Thompson, Scott M., Albuquerque, Edson X., Gould, Todd D.

“…Preclinical studies indicate that (2R,6R)-hydroxynorketamine (HNK) is a putative fast-acting antidepressant candidate. Although inhibition of NMDA-type…”
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Sex-dependent metabolism of ketamine and (2R,6R)-hydroxynorketamine in mice and humans by Highland, Jaclyn N, Farmer, Cristan A, Zanos, Panos, Lovett, Jacqueline, Zarate, Carlos A, Moaddel, Ruin, Gould, Todd D

“…Background: Ketamine is rapidly metabolized to norketamine and hydroxynorketamine (HNK) metabolites. In female mice, when compared to males, higher levels of…”
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Assessment of NAD+metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle by Demarest, Tyler G., Truong, Gia Thinh D., Lovett, Jacqueline, Mohanty, Joy G., Mattison, Julie A., Mattson, Mark P., Ferrucci, Luigi, Bohr, Vilhelm A., Moaddel, Ruin

“…The reduction-oxidation state of NAD+/NADH is critical for cellular health with NAD+ and its metabolites playing critical roles in aging and pathologies. Given…”
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Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of (2R,6R)-hydroxynorketamine by Highland, Jaclyn N, Morris, Patrick J, Zanos, Panos, Lovett, Jacqueline, Ghosh, Soumita, Wang, Amy Q, Zarate, Carlos A, Thomas, Craig J, Moaddel, Ruin, Gould, Todd D

“…Background: (R,S)-ketamine has gained attention for its rapid-acting antidepressant actions in patients with treatment-resistant depression. However,…”
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Ketamine for Refractory Chronic Migraine: An Observational Pilot Study and Metabolite Analysis by Schwenk, Eric S., Torjman, Marc C., Moaddel, Ruin, Lovett, Jacqueline, Katz, Daniel, Denk, William, Lauritsen, Clinton, Silberstein, Stephen D., Wainer, Irving W.

“…Patients with refractory chronic migraine have substantial disability and have failed many acute and preventive medications. When aggressive intravenous…”
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Cross‐sectional analysis of healthy individuals across decades: Aging signatures across multiple physiological compartments by Moaddel, Ruin, Ubaida‐Mohien, Ceereena, Tanaka, Toshiko, Tian, Qu, Candia, Julián, Moore, Ann Zenobia, Lovett, Jacqueline, Fantoni, Giovanna, Shehadeh, Nader, Turek, Lisa, Collingham, Victoria, Kaileh, Mary, Chia, Chee W., Sen, Ranjan, Egan, Josephine M., Ferrucci, Luigi

“…The study of age‐related biomarkers from different biofluids and tissues within the same individual might provide a more comprehensive understanding of…”
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