Search Results - "LOVENBERG, T"

Acute wake‐promoting actions of JNJ‐5207852, a novel, diamine‐based H 3 antagonist by Barbier, A J, Berridge, C, Dugovic, C, Laposky, A D, Wilson, S J, Boggs, J, Aluisio, L, Lord, B, Mazur, C, Pudiak, C M, Langlois, X, Xiao, W, Apodaca, R, Carruthers, N I, Lovenberg, T W

“…1‐[4‐(3‐piperidin‐1‐yl‐propoxy)‐benzyl]‐piperidine (JNJ‐5207852) is a novel, non‐imidazole histamine H 3 receptor antagonist, with high affinity at the rat (p…”
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Histamine H3 receptor antagonists: from target identification to drug leads by Bonaventure, P, Letavic, M, Dugovic, C, Wilson, S, Aluisio, L, Pudiak, C, Lord, B, Mazur, C, Kamme, F, Nishino, S, Carruthers, N, Lovenberg, T

“…The successful cloning and functional expression of the histamine H(3) receptor in the late 1990 s has greatly facilitated our efforts to identify small…”
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Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior by HEINRICHS, S. C, LAPSANSKY, J, LOVENBERG, T. W, DE SOUZA, E. B, CHALMERS, D. T

“…The recent identification and differential localization in brain of three binding sites for corticotropin-releasing factor (CRF)-like peptides (CRF1 and CRF2…”
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Cloning and Characterization of a Functionally Distinct Corticotropin- Releasing Factor Receptor Subtype from Rat Brain by Lovenberg, Timothy W., Liaw, Chen W., Grigoriadis, Dimitri E., Clevenger, William, Chalmers, Derek T., De Souza, Errol B., Oltersdorf, Tilman

“…The present study reports the isolation of a cDNA clone that encodes a second member of the corticotropin-releasing factor (CRF) receptor family, designated as…”
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Radioligand binding analysis of knockout mice reveals 5-HYDROXYTRYPTAMINE7 receptor distribution and uncovers 8-hydroxy-2-(DI-N-propylamino)tetralin interaction with α2 adrenergic receptors by BONAVENTURE, P, NEPOMUCENO, D, HEIN, L, SUTCLIFFE, J. G, LOVENBERG, T, HEDLUND, P. B

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Identification of Relaxin-3/INSL7 as an Endogenous Ligand for the Orphan G-protein-coupled Receptor GPCR135 by Liu, Changlu, Eriste, Elo, Sutton, Steven, Chen, Jingcai, Roland, Barbara, Kuei, Chester, Farmer, Niven, Jörnvall, Hans, Sillard, Rannar, Lovenberg, Timothy W.

“…GPCR135, publicly known as somatostatin- and angiotensin-like peptide receptor, is expressed in the central nervous system and its cognate ligand(s) has not…”
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A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms by Lovenberg, T W, Baron, B M, de Lecea, L, Miller, J D, Prosser, R A, Rea, M A, Foye, P E, Racke, M, Slone, A L, Siegel, B W

“…We report the cloning and characterization of a novel serotonin receptor, designated as 5-HT7, which is coupled to the stimulation of adenylyl cyclase. 5-HT7…”
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P.1.c.010 Effect of JNJ-10181457, a selective H3 receptor antagonist, on dopamine release in the rat nucleus accumbens by Bonaventure, P, Aluisio, L, Fraser, I, Lovenberg, T

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Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow by Liu, C, Ma, X, Jiang, X, Wilson, S J, Hofstra, C L, Blevitt, J, Pyati, J, Li, X, Chai, W, Carruthers, N, Lovenberg, T W

“…Histamine is a multifunctional hormone that regulates smooth muscle contraction in the airways, acid secretion in the gut, and neurotransmitter release in the…”
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Cloning and functional expression of the human histamine H3 receptor by Lovenberg, T W, Roland, B L, Wilson, S J, Jiang, X, Pyati, J, Huvar, A, Jackson, M R, Erlander, M G

“…Histamine regulates neurotransmitter release in the central and peripheral nervous systems through H3 presynaptic receptors. The existence of the histamine H3…”
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Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression by Chalmers, DT, Lovenberg, TW, De Souza, EB

“…Corticotropin-releasing factor (CRF) is the primary factor involved in controlling the release of ACTH from the anterior pituitary and also acts as a…”
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Measurement of hypocretin/orexin content in the mouse brain using an enzyme immunoassay: the effect of circadian time, age and genetic background by Lin, L., Wisor, J., Shiba, T., Taheri, S., Yanai, K., Wurts, S., Lin, X., Vitaterna, M., Takahashi, J., Lovenberg, T.W., Koehl, M., Uhl, G., Nishino, S., Mignot, E.

“…The hypocretins (1 and 2) have emerged as key regulators of sleep and wakefulness. We developed a high-throughput enzyme immunoassay (EIA) to measure total…”
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Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders by Behan, D P, Grigoriadis, D E, Lovenberg, T, Chalmers, D, Heinrichs, S, Liaw, C, De Souza, E B

“…The actions of CRF in the brain and in the periphery are mediated through multiple binding sites. There are three receptors, CRF1, CRF2 alpha and CRF2 beta,…”
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CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues by Lovenberg, T W, Chalmers, D T, Liu, C, De Souza, E B

“…We have recently described the cloning and characterization of a novel corticotropin-releasing factor receptor subtype (CRF2) from rat brain that exists in two…”
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Anatomical distribution of prolactin-releasing peptide and its receptor suggests additional functions in the central nervous system and periphery by Roland, B L, Sutton, S W, Wilson, S J, Luo, L, Pyati, J, Huvar, R, Erlander, M G, Lovenberg, T W

“…A recently identified neuropeptide with PRL-releasing capabilities binds to and activates a previously known orphan G protein-coupled receptor, GPR10. We…”
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Corticotrophin-releasing factor receptors: from molecular biology to drug design by Chalmers, Derek T., Lovenberg, Timothy W., Grigoriadis, Dimitri E., Behan, Dominic P., De Souza, Errol B.

“…Corticotrophin-releasing factor (CRF) acts within both the brain and the periphery to coordinate the overall response of the body to stress. The involvement of…”
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Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid by Liaw, C W, Lovenberg, T W, Barry, G, Oltersdorf, T, Grigoriadis, D E, de Souza, E B

“…Two CRF receptor subtypes (CRF1 and CRF2 receptors) with distinct brain localizations and pharmacological profiles have recently been cloned and characterized…”
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Two Members of a Distinct Subfamily of 5-Hydroxytryptamine Receptors Differentially Expressed in Rat Brain by Erlander, Mark G., Lovenberg, Timothy W., Baron, Bruce M., de Lecea, Luis, Danielson, Patria E., Racke, Margaret, Slone, Amy L., Siegel, Barry W., Foye, Pamela E., Cannon, Keith, Burns, Jeffrey E., Sutcliffe, J. Gregor

“…We report two serotonin (5-hydroxytryptamine, 5-HT) receptors, MR22 and REC17, that belong to the G-protein-associated receptor superfamily. MR22 and REC17 are…”
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Targeted Disruption of RC3 Reveals a Calmodulin-Based Mechanism for Regulating Metaplasticity in the Hippocampus by Krucker, Thomas, Siggins, George R, McNamara, Robert K, Lindsley, Kristen A, Dao, Alan, Allison, David W, de Lecea, Luis, Lovenberg, Timothy W, Sutcliffe, J. Gregor, Gerendasy, Dan D

“…We used homologous recombination in the mouse to knock-out RC3, a postsynaptic, calmodulin-binding PKC substrate. Mutant brains exhibited lower…”
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Endocannabinoids and sleep: impact of monoacylglycerol lipase inhibition in rodent models by Dugovic, C., Yun, S., Lovenberg, T., Bonaventure, P.

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