Search Results - "LOUW, Abraham I"

Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities by Birkholtz, Lyn-Marie, Williams, Marni, Niemand, Jandeli, Louw, Abraham I, Persson, Lo, Heby, Olle

“…New drugs are urgently needed for the treatment of tropical and subtropical parasitic diseases, such as African sleeping sickness, Chagas' disease,…”
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Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae) by Moyo, Phanankosi, Kunyane, Phaladi, Selepe, Mamoalosi A, Eloff, Jacobus N, Niemand, Jandeli, Louw, Abraham I, Maharaj, Vinesh J, Birkholtz, Lyn-Marie

“…Optimal adoption of the malaria transmission-blocking strategy is currently limited by lack of safe and efficacious drugs. This has sparked the exploration of…”
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Natural Products: A Potential Source of Malaria Transmission Blocking Drugs? by Moyo, Phanankosi, Mugumbate, Grace, Eloff, Jacobus N, Louw, Abraham I, Maharaj, Vinesh J, Birkholtz, Lyn-Marié

“…The ability to block human-to-mosquito and mosquito-to-human transmission of parasites is fundamental to accomplish the ambitious goal of malaria elimination…”
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Co-inhibition of Plasmodium falciparum S-Adenosylmethionine Decarboxylase/Ornithine Decarboxylase Reveals Perturbation-specific Compensatory Mechanisms by Transcriptome, Proteome, and Metabolome Analyses by van Brummelen, Anna C., Olszewski, Kellen L., Wilinski, Daniel, Llinás, Manuel, Louw, Abraham I., Birkholtz, Lyn-Marie

“…Polyamines are ubiquitous components of all living cells, and their depletion usually causes cytostasis, a strategy employed for treatment of West African…”
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Heterologous expression of plasmodial proteins for structural studies and functional annotation by Birkholtz, Lyn-Marie, Blatch, Gregory, Coetzer, Theresa L, Hoppe, Heinrich C, Human, Esmaré, Morris, Elizabeth J, Ngcete, Zoleka, Oldfield, Lyndon, Roth, Robyn, Shonhai, Addmore, Stephens, Linda, Louw, Abraham I

“…Malaria remains the world's most devastating tropical infectious disease with as many as 40% of the world population living in risk areas. The widespread…”
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Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum by Reeksting, Shaun B, Müller, Ingrid B, Burger, Pieter B, Burgos, Emmanuel S, Salmon, Laurent, Louw, Abraham I, Birkholtz, Lyn-Marie, Wrenger, Carsten

“…Malaria tropica is a devastating infectious disease caused by Plasmodium falciparum. This parasite synthesizes vitamin B6 de novo via the PLP (pyridoxal…”
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A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail by Burger, Pieter B, Williams, Marni, Sprenger, Janina, Reeksting, Shaun B, Botha, Mariëtte, Müller, Ingrid B, Joubert, Fourie, Birkholtz, Lyn-Marie, Louw, Abraham I

“…Plasmodium falciparum is the most pathogenic of the human malaria parasite species and a major cause of death in Africa. It's resistance to most of the current…”
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Proteomic Profiling of Plasmodium falciparum through Improved, Semiquantitative Two-Dimensional Gel Electrophoresis by Smit, Salome, Stoychev, Stoyan, Louw, Abraham I, Birkholtz, Lyn-Marie

“…Two-dimensional gel electrophoresis (2-DE) is one of the most commonly used technologies to obtain a snapshot of the proteome at any specific time. However,…”
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Anthracene-Polyamine Conjugates Inhibit In Vitro Proliferation of Intraerythrocytic Plasmodium falciparum Parasites by NIEMAND, Jandeli, BURGER, Pieter, VERLINDEN, Bianca K, READER, Janette, JOUBERT, Annie M, KAISER, Annette, LOUW, Abraham I, KIRK, Kiaran, PHANSTIEL, Otto, BIRKHOLTZ, Lyn-Marie

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels by Becker, John V W, Mtwisha, Linda, Crampton, Bridget G, Stoychev, Stoyan, van Brummelen, Anna C, Reeksting, Shaun, Louw, Abraham I, Birkholtz, Lyn-Marie, Mancama, Dalu T

“…Plasmodium falciparum, the causative agent of severe human malaria, has evolved to become resistant to previously successful antimalarial chemotherapies, most…”
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Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites by le Roux, Dina, Burger, Pieter B., Niemand, Jandeli, Grobler, Anne, Urbán, Patricia, Fernàndez-Busquets, Xavier, Barker, Robert H., Serrano, Adelfa E., I. Louw, Abraham, Birkholtz, Lyn-Marie

“…[Display omitted] •A highly specific inhibitor, Genz-644131, was identified for P. falciparum AdoMetDC.•Increased specificity for bifunctional over…”
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MADIBA: a web server toolkit for biological interpretation of Plasmodium and plant gene clusters by Law, Philip J, Claudel-Renard, Clotilde, Joubert, Fourie, Louw, Abraham I, Berger, Dave K

“…Microarray technology makes it possible to identify changes in gene expression of an organism, under various conditions. Data mining is thus essential for…”
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Deletion mutagenesis of large areas in Plasmodium falciparum genes: a comparative study by Williams, Marni, Louw, Abraham I, Birkholtz, Lyn-Marie

“…The increasing emergence of Plasmodium falciparum parasites resistant to most of the cost-effective drugs has necessitated the identification of novel leads…”
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Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? by Birkholtz, Lyn-Marie, Bastien, Olivier, Wells, Gordon, Grando, Delphine, Joubert, Fourie, Kasam, Vinod, Zimmermann, Marc, Ortet, Philippe, Jacq, Nicolas, Saïdani, Nadia, Roy, Sylvaine, Hofmann-Apitius, Martin, Breton, Vincent, Louw, Abraham I, Maréchal, Eric

“…The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative…”
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Pathogenic mechanisms of sand tampan toxicoses induced by the tick, Ornithodoros savignyi by MANS, Ben J, STEINMANN, Christiaan M. L, VENTER, Jacobus D, LOUW, Abraham I, NEITZ, Albert W. H

“…The tick, Ornithodoros savignyi has been implicated in inducing paralysis and tampan toxicosis. In this study, a basic toxin (TSGP4) was identified and the…”
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Mutational Analysis of the Hexose Transporter of Plasmodium falciparum and Development of a Three-dimensional Model by Manning, Suzanne K, Woodrow, Charles, Zuniga, Felipe A, Iserovich, Pavel, Fischbarg, Jorge, Louw, Abraham I, Krishna, Sanjeev

“…Plasmodium falciparum infection kills more than 1 million children annually. Novel drug targets are urgently being sought as multidrug resistance limits the…”
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Evolution of hematophagy in ticks: common origins for blood coagulation and platelet aggregation inhibitors from soft ticks of the genus Ornithodoros by Mans, Ben J, Louw, Abraham I, Neitz, Albert W H

“…Identification and characterization of antihemostatic components from hematophagous organisms are useful for the elucidation of the evolutionary mechanisms…”
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Savignygrin, a platelet aggregation inhibitor from the soft tick Ornithodoros savignyi, presents the RGD integrin recognition motif on the Kunitz-BPTI fold by Mans, Ben J, Louw, Abraham I, Neitz, Albert W H

“…Savignygrin, a platelet aggregation inhibitor that possesses the RGD integrin recognition motif, has been purified from the soft tick Ornithodoros savignyi…”
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Biochemical characterisation and novel classification of monofunctional S-adenosylmethionine decarboxylase of Plasmodium falciparum by Williams, Marni, Sprenger, Janina, Human, Esmaré, Al-Karadaghi, Salam, Persson, Lo, Louw, Abraham I., Birkholtz, Lyn-Marie

“…We report the biochemical, biophysical and structural characterization of monofunctional S-adenosylmethionine decarboxylase from Plasmodium falciparum, which…”
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activity of Plasmodium falciparum arginase is mediated by a novel inter-monomer salt-bridge between Glu295-Arg404 by Wells, Gordon A, Müller, Ingrid B, Wrenger, Carsten, Louw, Abraham I

“…A recent study implicated a role for Plasmodium falciparum arginase in the systemic depletion of arginine levels, which in turn has been associated with human…”
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