Search Results - "LOTTI, V. J"

Biochemical and Pharmacological Characterization of an Extremely Potent and Selective Nonpeptide Cholecystokinin Antagonist by Raymond S. L. Chang, Lotti, Victor J.

“…3S(-)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H -1,4-benzodiazepine-3-yl)-1H-indole-2-carboxamide (L-364,718) interacted in a competitive manner with rat…”
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Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands by Chang, R S, Lotti, V J

“…The nonpeptide angiotensin II antagonists Dup-89 and WL-19 displaced specific 125I-angiotensin II binding in rat whole adrenal in a clearly biphasic manner,…”
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Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists by Evans, B. E, Rittle, K. E, Bock, M. G, DiPardo, R. M, Freidinger, R. M, Whitter, W. L, Lundell, G. F, Veber, D. F, Anderson, P. S, Chang, R. S. L, Lotti, V. J, Cerino, D. J, Chen, T. B, Kling, P. J, Kunkel, K. A, Springer, J. P, Hirshfield, J

“…3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described. Developed by reasoned modification of…”
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A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260 by Lotti, V J, Chang, R S

“…L-365,260 (3R(+)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4- benzodiazepin-3-yl)-N'-(3-methylphenyl)urea), interacted in a stereoselective and competitive…”
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In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist by Chang, R S, Siegl, P K, Clineschmidt, B V, Mantlo, N B, Chakravarty, P K, Greenlee, W J, Patchett, A A, Lotti, V J

“…L-158,809 interacted in a competitive manner with rabbit aortic angiotensin II (AII) receptors as determined by Scatchard analysis of the specific binding of…”
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In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist by Siegl, P K, Chang, R S, Mantlo, N B, Chakravarty, P K, Ondeyka, D L, Greenlee, W J, Patchett, A A, Sweet, C S, Lotti, V J

“…L-158,809 (5,7-dimethyl-2-ethyl-3-[[2'-(1H-tetrazol-5yl)[1,1']-bi- phenyl-4-yl]-methyl]-3H-imidazo[4,5-b]pyridine) is a potent, competitive and specific…”
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Characterization of the binding of [3H]L-365,260: a new potent and selective brain cholecystokinin (CCK-B) and gastrin receptor antagonist radioligand by Chang, R S, Chen, T B, Bock, M G, Freidinger, R M, Chen, R, Rosegay, A, Lotti, V J

“…[3H]L-365,260, [(3R-(+)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4- benzodiazepin-3-yl)-N'-(3-methylphenyl)urea], a new potent and selective nonpeptide brain…”
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Cardiac angiotensin receptors: effects of selective angiotensin II receptor antagonists, DUP 753 and PD 121981, in rabbit heart by Scott, A L, Chang, R S, Lotti, V J, Siegl, P K

“…Angiotensin II (AII) elicits a positive inotropic response in cardiac muscle preparations from several species including humans. The purpose of this study was…”
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Discovery of L-162,313: a nonpeptide that mimics the biological actions of angiotensin II by Kivlighn, S D, Huckle, W R, Zingaro, G J, Rivero, R A, Lotti, V J, Chang, R S, Schorn, T W, Kevin, N, Johnson, Jr, R G, Greenlee, W J

“…L-162,313 (5,7-dimethyl-2-ethyl-3-[[4-[2(n- butyloxycarbonylsulfonamido)-5-isobutyl-3-thienyl]phenyl]methyl]- imadazo[4,5-b]pyridine) is a nonpeptide that…”
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A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066 by Clineschmidt, B V, Pettibone, D J, Lotti, V J, Hucker, H B, Sweeney, B M, Reiss, D R, Lis, E V, Huff, J R, Vacca, J

“…L-659,066 has been characterized as a potent and selective alpha-2 adrenoceptor antagonist. Both in vitro and in vivo, L-659,066 exhibited specificity…”
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In vivo pharmacology of L-364,718, a new potent nonpeptide peripheral cholecystokinin antagonist by Lotti, V J, Pendleton, R G, Gould, R J, Hanson, H M, Chang, R S, Clineschmidt, B V

“…The in vivo pharmacological activity of L-364,718, a new, potent peripheral cholecystokinin (CCK) antagonist, was characterized in several species using assay…”
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Angiotensin receptor subtypes in rat, rabbit and monkey tissues: relative distribution and species dependency by Chang, R S, Lotti, V J

“…The displacement of [125I]Sar1, Ile8 angiotensin II binding by the receptor subtype selective angiotensin II antagonists, DuP-753 and WL-19 (PD121981) was used…”
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Characterization of the binding of [3H]-(+/-)-L-364,718: a new potent, nonpeptide cholecystokinin antagonist radioligand selective for peripheral receptors by Chang, R S, Lotti, V J, Chen, T B, Kunkel, K A

“…[3H]-(+/-)-L-364,718 a new, potent and selective nonpeptide peripheral cholecystokinin (CCK) antagonist bound saturably and reversibly to rat pancreatic…”
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Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists by Mantlo, Nathan B, Chakravarty, Prasun K, Ondeyka, Debra L, Siegl, Peter K. S, Chang, Raymond S, Lotti, Victor J, Faust, Kristie A, Schorn, Terry W, Chen, Tsing Bau

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Characterization of the binding of [3H]L-158,809: a new potent and selective nonpeptide angiotensin II receptor (AT1) antagonist radioligand by Chen, T B, Lotti, V J, Chang, R S

“…[3H]L-158,809, a new potent and AT1-selective nonpeptide angiotensin II receptor antagonist, bound saturably and reversibly to rat adrenal membranes. Scatchard…”
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A Potent Nonpeptide Cholecystokinin Antagonist Selective for Peripheral Tissues Isolated from Aspergillus alliaceus by Raymond S. L. Chang, Lotti, Victor J., Monaghan, Richard L., Birnbaum, Jerome, Stapley, Edward O., Goetz, Michael A., Albers-Schönberg, Georg, Patchett, Arthur A., Liesch, Jerrold M., Hensens, Otto D., Springer, James P.

“…A new, competitive, nonpeptide cholecystokinin (CCK) antagonist, asperlicin, was isolated from the fungus Aspergillus alliaceus. The compound has 300 to 400…”
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Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates by Ashton, Wallace T, Hutchins, Steven M, Greenlee, William J, Doss, George A, Chang, Raymond S. L, Lotti, Victor J, Faust, Kristie A, Chen, Tsing Bau, Zingaro, Gloria J

“…Two series of potential angiotensin II antagonists derived from carboxyl-functionalized "diazole" heterocycles have been prepared and evaluated. Initially, a…”
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Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles by Ashton, Wallace T, Cantone, Christine L, Chang, Linda L, Hutchins, Steven M, Strelitz, Robert A, MacCoss, Malcolm, Chang, Raymond S. L, Lotti, Victor J, Faust, Kristie A

“…By a variety of synthetic routes, we have synthesized a series of 3,4,5-trisubstituted 4H-1,2,4-triazoles and a related series of…”
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Asperlicin, a novel non-peptidal cholecystokinin antagonist from Aspergillus alliaceus. Fermentation, isolation and biological properties by Goetz, M A, Lopez, M, Monaghan, R L, Chang, R S, Lotti, V J, Chen, T B

“…The fermentation and isolation of a new, non-peptide cholecystokinin antagonist, asperlicin, produced by Aspergillus alliaceus is described. The potent and…”
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Specific [3H]propionyl-neuropeptide Y (NPY) binding in rabbit aortic membranes: comparisons with binding in rat brain and biological responses in rat vas deferens by Chang, R S, Lotti, V J, Chen, T B

“…The binding of biologically active [3H]propionyl-NPY to rabbit aortic membranes was specific and saturable. Scatchard analysis indicated a single class of…”
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