Search Results - "LOSSOS, Alexander"

Neurologic complications of immune checkpoint inhibitors by Fellner, Avi, Makranz, Chen, Lotem, Michal, Bokstein, Felix, Taliansky, Alisa, Rosenberg, Shai, Blumenthal, Deborah T., Mandel, Jacob, Fichman, Suzana, Kogan, Elena, Steiner, Israel, Siegal, Tali, Lossos, Alexander, Yust-Katz, Shlomit

“…Immune checkpoint inhibitors (ICPIs) have recently emerged as a novel treatment for cancer. These agents, transforming the field of oncology, are not devoid of…”
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A case report of unilateral cervical lymphadenopathy and multiple cranial neuropathies following mRNA-COVID-19 vaccination by Shalabi, Fatma, Lossos, Alexander, Karussis, Dimitrios

“…Background We report a rare case of ipsilateral multiple cranial neuropathy and ipsilateral lymphadenopathy following mRNA-COVID-19 vaccination. Case…”
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European Association of Neuro-Oncology (EANO) guidelines for treatment of primary central nervous system lymphoma (PCNSL) by Hoang-Xuan, Khê, Deckert, Martina, Ferreri, Andrés J M, Furtner, Julia, Gallego Perez-Larraya, Jaime, Henriksson, Roger, Hottinger, Andreas F, Kasenda, Benjamin, Lefranc, Florence, Lossos, Alexander, McBain, Catherine, Preusser, Matthias, Roth, Patrick, Rudà, Roberta, Schlegel, Uwe, Soffietti, Riccardo, Soussain, Carole, Taphoorn, Martin J B, Touitou, Valérie, Weller, Michael, Bromberg, Jacoline E C

“…The management of primary central nervous system (PCNSL) is one of the most controversial topics in neuro-oncology because of the complexity of the disease and…”
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Amylopectinosis of the fatal epilepsy Lafora disease resists autophagic glycogen catabolism by Wu, Jun, Kakhlon, Or, Weil, Miguel, Lossos, Alexander, Minassian, Berge A

“…In this Correspondence, B. Minassian and colleagues report that GHF201, an autophagy activator shown to diminish abnormal glycogen aggregates in a mouse model…”
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Short report: Plasma based biomarkers detect radiation induced brain injury in cancer patients treated for brain metastasis: A pilot study by Makranz, Chen, Lubotzky, Asael, Zemmour, Hai, Shemer, Ruth, Glaser, Benjamin, Cohen, Jonathan, Maoz, Myriam, Sapir, Eli, Wygoda, Marc, Peretz, Tamar, Weizman, Noam, Feldman, Jon, Abrams, Ross A, Lossos, Alexander, Dor, Yuval, Zick, Aviad

“…Background Radiotherapy has an important role in the treatment of brain metastases but carries risk of short and/or long-term toxicity, termed…”
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MYORG Mutations: a Major Cause of Recessive Primary Familial Brain Calcification by Bauer, Max, Rahat, Dolev, Zisman, Elad, Tabach, Yuval, Lossos, Alexander, Meiner, Vardiella, Arkadir, David

“…Purpose of Review Until recently, the gene associated with the recessive form of familial brain calcification (PFBC, Fahr disease) was unknown. MYORG , a gene…”
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Germline-driven replication repair-deficient high-grade gliomas exhibit unique hypomethylation patterns by Dodgshun, Andrew J., Fukuoka, Kohei, Edwards, Melissa, Bianchi, Vanessa J., Das, Anirban, Sexton-Oates, Alexandra, Larouche, Valérie, Vanan, Magimairajan I., Lindhorst, Scott, Yalon, Michal, Mason, Gary, Crooks, Bruce, Constantini, Shlomi, Massimino, Maura, Chiaravalli, Stefano, Ramdas, Jagadeesh, Mason, Warren, Ashraf, Shamvil, Farah, Roula, Van Damme, An, Opocher, Enrico, Hamid, Syed Ahmer, Ziegler, David S., Samuel, David, Cole, Kristina A., Tomboc, Patrick, Stearns, Duncan, Thomas, Gregory A., Lossos, Alexander, Sullivan, Michael, Hansford, Jordan R., Mackay, Alan, Jones, Chris, Jones, David T. W., Ramaswamy, Vijay, Hawkins, Cynthia, Bouffet, Eric, Tabori, Uri

“…Replication repair deficiency (RRD) leading to hypermutation is an important driving mechanism of high-grade glioma (HGG) occurring predominantly in the…”
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Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism by Kakhlon, Or, Vaknin, Hilla, Mishra, Kumudesh, D’Souza, Jeevitha, Marisat, Monzer, Sprecher, Uri, Wald‐Altman, Shane, Dukhovny, Anna, Raviv, Yuval, Da’adoosh, Benny, Engel, Hamutal, Benhamron, Sandrine, Nitzan, Keren, Sweetat, Sahar, Permyakova, Anna, Mordechai, Anat, Akman, Hasan Orhan, Rosenmann, Hanna, Lossos, Alexander, Tam, Joseph, Minassian, Berge A., Weil, Miguel

“…This work employs adult polyglucosan body disease (APBD) models to explore the efficacy and mechanism of action of the polyglucosan‐reducing compound 144DG11…”
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Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design by Froese, D Sean, Michaeli, Amit, McCorvie, Thomas J, Krojer, Tobias, Sasi, Meitav, Melaev, Esther, Goldblum, Amiram, Zatsepin, Maria, Lossos, Alexander, Álvarez, Rafael, Escribá, Pablo V, Minassian, Berge A, von Delft, Frank, Kakhlon, Or, Yue, Wyatt W

“…Glycogen branching enzyme 1 (GBE1) plays an essential role in glycogen biosynthesis by generating α-1,6-glucosidic branches from α-1,4-linked glucose chains,…”
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Adult polyglucosan body disease: Natural History and Key Magnetic Resonance Imaging Findings by Mochel, Fanny, Schiffmann, Raphael, Steenweg, Marjan E., Akman, Hasan O., Wallace, Mary, Sedel, Frédéric, Laforêt, Pascal, Levy, Richard, Powers, J. Michael, Demeret, Sophie, Maisonobe, Thierry, Froissart, Roseline, Da Nobrega, Bruno Barcelos, Fogel, Brent L., Natowicz, Marvin R., Lubetzki, Catherine, Durr, Alexandra, Brice, Alexis, Rosenmann, Hanna, Barash, Varda, Kakhlon, Or, Gomori, J. Moshe, van der Knaap, Marjo S., Lossos, Alexander

“…Objective: Adult polyglucosan body disease (APBD) is an autosomal recessive leukodystrophy characterized by neurogenic bladder, progressive spastic gait, and…”
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Triacylglycerol mimetics regulate membrane interactions of glycogen branching enzyme: implications for therapy by Alvarez, Rafael, Casas, Jesús, López, David J., Ibarguren, Maitane, Suari-Rivera, Ariadna, Terés, Silvia, Guardiola-Serrano, Francisca, Lossos, Alexander, Busquets, Xavier, Kakhlon, Or, Escribá, Pablo V.

“…Adult polyglucosan body disease (APBD) is a neurological disorder characterized by adult-onset neurogenic bladder, spasticity, weakness, and sensory loss. The…”
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Neurological misdiagnoses of lymphoma by Makranz, Chen, Arkadir, David, Nachmias, Boaz, Gatt, Moshe E., Eliahou, Ruth, Atlan, Karine, Mordechai, Anat, Goldshmit, Netta, Lossos, Alexander

“…Background Lymphoma of the nervous system is rare and usually involves the brain, spinal cord, or peripheral nerves. Hence, it has varied clinical…”
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KIF1A missense mutations in SPG30, an autosomal recessive spastic paraplegia: distinct phenotypes according to the nature of the mutations by KLEBEL, Stephan, LOSSOS, Alexander, RASTETTER, Agnes, MARTIN, Elodie, BOUTEILLER, Delphine, ORLANDO, Laurent, GYAPAY, Gabor, EL-HACHIMI, Khalid H, ZIMMERMAN, Batel, GAMLIEL, Moriya, MISK, Adel, LERER, Israela, AZZEDINE, Hamid, BRICE, Alexis, DURR, Alexandra, STEVANIN, Giovanni, MUNDWILLER, Emeline, SHEFFER, Ruth, GAUSSEN, Marion, MARELLI, Cecilia, NAWARA, Magdalena, CARPENTIER, Wassila, MEYER, Vincent

“…The hereditary spastic paraplegias (HSPs) are a clinically and genetically heterogeneous group of neurodegenerative diseases characterised by progressive…”
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Multi-system neurological disorder associated with a CRYAB variant by Sadeh, Menachem, Rahat, Dolev, Meiner, Vardiella, Fellig, Yakov, Arad, Michael, Schueler-Furman, Ora, Hu, Ying, Li, Yan, Bönnemann, Carsten G., Lossos, Alexander

“…We report a multiplex family with extended multisystem neurological phenotype associated with a CRYAB variant. Two affected siblings were evaluated with whole…”
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Identification of the SPG15 Gene, Encoding Spastizin, as a Frequent Cause of Complicated Autosomal-Recessive Spastic Paraplegia, Including Kjellin Syndrome by Hanein, Sylvain, Martin, Elodie, Boukhris, Amir, Byrne, Paula, Goizet, Cyril, Hamri, Abdelmadjid, Benomar, Ali, Lossos, Alexander, Denora, Paola, Fernandez, José, Elleuch, Nizar, Forlani, Sylvie, Durr, Alexandra, Feki, Imed, Hutchinson, Michael, Santorelli, Filippo M., Mhiri, Chokri, Brice, Alexis, Stevanin, Giovanni

“…Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders. Both “uncomplicated” and “complicated” forms have been…”
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Clinical utility and treatment outcome of comprehensive genomic profiling in high grade glioma patients by Blumenthal, Deborah T., Dvir, Addie, Lossos, Alexander, Tzuk-Shina, Tzahala, Lior, Tzach, Limon, Dror, Yust-Katz, Shlomit, Lokiec, Alejandro, Ram, Zvi, Ross, Jeffrey S., Ali, Siraj M., Yair, Roi, Soussan-Gutman, Lior, Bokstein, Felix

“…Genomic research of high grade glioma (HGG) has revealed complex biology with potential for therapeutic impact. However, the utilization of this information…”
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SCLC, Paraneoplastic Dermatomyositis, Positive Transcription Intermediary Factor 1-γ, and Point Mutation in the Transcription Intermediary Factor 1-γ Coding Gene: A Case Report by Arnon, Johnathan, Elia, Anna, Nevo, Yuval, Lossos, Alexander, Nechushtan, Hovav

“…SCLC is frequently associated with paraneoplastic syndromes, including dermatomyositis. Patients with malignancy-associated dermatomyositis express a specific…”
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In vivo assessment of the window of barrier opening after osmotic blood-brain barrier disruption in humans by SIEGAL, T, RUBINSTEIN, R, BOKSTEIN, F, SCHWARTZ, A, LOSSOS, A, SHALOM, E, CHISIN, R, GOMORI, J. M

“…Osmotic blood-brain barrier (BBB) disruption induced by intraarterial infusion of mannitol is used in conjunction with chemotherapy to treat human brain…”
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Long-circulating liposomes for drug delivery in cancer therapy: a review of biodistribution studies in tumor-bearing animals by Gabizon, Alberto, Goren, Dorit, Horowitz, Aviva T., Tzemach, Dinah, Lossos, Alexander, Siegal, Tali

“…Inhibition of the rapid uptake of liposomes by the reticulo-endothelial system (RES) and reduction of the rate of drug leakage have resulted in…”
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Teaching Neuro Images : Hypertrophic olivary degeneration in a young man with POLG gene mutation by Arkadir, David, Meiner, Vardiella, Karni, Arnon, Lossos, Alexander

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