Search Results - "LOSKUTOFF, D. J."

The Adipocyte and Hemostatic Balance in Obesity: Studies of PAI-1 by Loskutoff, David J, Samad, Fahumiya

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Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice by Samad, F, Loskutoff, D J

“…Although elevated plasminogen activator inhibitor-1 (PAI-1) is associated with obesity and may be a risk factor for cardiovascular disease, the mechanism(s)…”
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An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct by Abe, M, Harpel, J G, Metz, C N, Nunes, I, Loskutoff, D J, Rifkin, D B

“…Transforming growth factor-beta (TGF-beta) is a potent regulator of cellular differentiation, proliferation, migration, and protein expression. These…”
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Disruption of the plasminogen activator inhibitor‐1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice by Schäfer, Katrin, Fujisawa, Kazuhiku, Konstantinides, Stavros, Loskutoff, David J.

“…ABSTRACT Elevated levels of plasma and adipose tissue plasminogen activator inhibitor‐1 (PAI‐1) are observed frequently in obese humans and rodents. In this…”
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Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide by Samad, F, Yamamoto, K, Loskutoff, D J

“…Although elevated plasma plasminogen activator inhibitor 1 (PAI-1) is associated with obesity, very little is known about its tissue or cellular origin, or…”
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PAI-1, fibrosis, and the elusive provisional fibrin matrix by Loskutoff, D J, Quigley, J P

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Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo : tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-α, and transforming growth factor-β by SAWDEY, M. S, LOSKUTOFF, D. J

“…The regulation of type 1 plasminogen activator inhibitor (PAI-1) gene expression was studied in vivo employing a murine model system. Nuclease protection…”
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The leptin receptor system of human platelets by GIANDOMENICO, G., DELLAS, C., CZEKAY, R‐P, KOSCHNICK, S., LOSKUTOFF, D. J.

“…Obesity is associated with elevated levels of leptin in the blood. Elevated leptin is a risk factor for thrombosis in humans, and leptin administration…”
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Increased Type 1 Plasminogen Activator Inhibitor Gene Expression in Atherosclerotic Human Arteries by Schneiderman, Jacob, Sawdey, Michael S., Keeton, Mark R., Bordin, Gerald M., Bernstein, Eugene F., Dilley, Ralph B., Loskutoff, David J.

“…Decreased fibrinolytic capacity has been suggested to accelerate the process of arterial atherogenesis by facilitating thrombosis and fibrin deposition within…”
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Tissue distribution of factor VIII gene expression in vivo--a closer look by Hollestelle, M J, Thinnes, T, Crain, K, Stiko, A, Kruijt, J K, van Berkel, T J, Loskutoff, D J, van Mourik, J A

“…Previous studies have shown that factor VIII (FVIII) is expressed by multiple tissues. However, little is known about its cellular origin or its level of…”
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Elevated expression of transforming growth factor-beta in adipose tissue from obese mice by Samad, F, Yamamoto, K, Pandey, M, Loskutoff, D J

“…Tumor necrosis factor-alpha (TNF-alpha) is chronically elevated in the adipose tissue from obese humans and mice. This increase in TNF-alpha contributes to the…”
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Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor by Schleef, R R, Bevilacqua, M P, Sawdey, M, Gimbrone, M A, Loskutoff, D J

“…Regulation of the fibrinolytic system of cultured human umbilical vein endothelial cells (HUVECs) by recombinant interleukin 1 beta (rIL-1 beta) and tumor…”
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Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells by Jirik, FR, Podor, TJ, Hirano, T, Kishimoto, T, Loskutoff, DJ, Carson, DA, Lotz, M

“…The interaction between human endothelial cells and leukocytes during immunologic and inflammatory responses is in part mediated through the release of soluble…”
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Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta by KEETON, M. R, CURRIDEN, S. A, VAN ZONNEVELD, A.-J, LOSKUTOFF, D. J

“…Regulation of the human type 1 plasminogen activator inhibitor (PAI-1) promoter by transforming growth factor-beta (TGF beta) was studied. An 800-base pair…”
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Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition by Pinsky, D J, Liao, H, Lawson, C A, Yan, S F, Chen, J, Carmeliet, P, Loskutoff, D J, Stern, D M

“…Oxygen deprivation, as occurs during tissue ischemia, tips the natural anticoagulant/procoagulant balance of the endovascular wall to favor activation of…”
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Regulation of type 1 plasminogen activator inhibitor gene expression in cultured bovine aortic endothelial cells. Induction by transforming growth factor-beta, lipopolysaccharide, and tumor necrosis factor-alpha by SAWDEY, M, PODOR, T. J, LOSKUTOFF, D. J

“…Cultured bovine aortic endothelial cells (BAEs) synthesize and secrete type 1 plasminogen activator inhibitor (PAI-1), an Mr 50,000 glycoprotein which inhibits…”
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Purification of a protein from bovine plasma that binds to type 1 plasminogen activator inhibitor and prevents its interaction with extracellular matrix. Evidence that the protein is vitronectin by MIMURO, J, LOSKUTOFF, D. J

“…Type 1 plasminogen activator inhibitor (PAI-1) binds to the extracellular matrix of cultured bovine aortic endothelial cells. Bovine plasma and bovine lung…”
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Monocyte Chemoattractant Protein 1 in Obesity and Insulin Resistance by Sartipy, Peter, Loskutoff, David J.

“…This study identifies monocyte chemoattractant protein 1 (MCP-1) as an insulin-responsive gene. It also shows that insulin induces substantial expression and…”
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Induction of plasminogen activator inhibitor 1 gene expression in murine liver by lipopolysaccharide. Cellular localization and role of endogenous tumor necrosis factor-alpha by Fearns, C, Loskutoff, DJ

“…We previously demonstrated that lipopolysaccharide (LPS) induces plasminogen activator inhibitor 1 (PAI-1) gene expression primarily in endothelial cells in…”
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Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants by Hekman, C M, Loskutoff, D J

“…Conditioned medium from cultured bovine aortic endothelial cells contains an inactive plasminogen activator inhibitor (PAI). This latent PAI can be “activated”…”
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