Search Results - "LOSER, Roland"

In Vitro and in Vivo Antitumor Activity of Methotrexate Conjugated to Human Serum Albumin in Human Cancer Cells by WOSIKOWSKI, Katja, BIEDERMANN, Elfi, RATTEL, Benno, BREITER, Norbert, JANK, Peter, LOSER, Roland, JANSEN, Gerrit, PETERS, Godefridus J

“…To avoid systemic toxicity of the cytotoxic drug methotrexate (MTX) and to improve tumor selectivity, MTX was bound to human serum albumin (HSA) as a drug…”
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WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells by WOSIKOWSKI, Katja, MATTERN, Karin, SCHEMAINDA, Isabel, HASMANN, Max, RATTEL, Benno, LOSER, Roland

“…We recently developed a class of novel antitumor agents that elicit a potent growth-inhibitory response in many tumor cells cultured in vitro. WK175, a member…”
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The effects of lifibrol (K12.148) on the cholesterol metabolism of cultured cells: evidence for sterol independent stimulation of the LDL receptor pathway by Scharnagl, Hubert, Schliack, Michael, Löser, Roland, Nauck, Markus, Gierens, Hedi, Jeck, Nikola, Wieland, Heinrich, Groß, Werner, März, Winfried

“…Lifibrol (4-(4′-tert. butylphenyl)-1-(4′-carboxyphenoxy)-2-butanol) is a new hypocholesterolemic compound; it effectively lowers low density lipoprotein (LDL)…”
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New Hypocholesterolemic Abietamide Derivatives. I. Structure-activity Relationship by FUJITA, YUKIO, SEMPUKU, KENJI, KITAGUCHI, KOJI, MORI, TAMIKI, MURAI, HIROMU, YOSHIKUNI, YOSHIAKI, ENOMOTO, HIROSHI, LOSER, ROLAND

“…Various amides of tetrahydroabietic, Δ8-dihydroabietic, abietic and dehydroabietic acids were prepared and tested for hypocholesterolemic activity in…”
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Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma by Drevs, Joachim, Löser, Roland, Rattel, Benno, Esser, Norbert

“…FK866/K22.175 (FK-866), developed as an anticancer agent, interferes with the NAD+ biosynthesis and therefore might have characteristics distinct from…”
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Polyethylene Glycol Conjugates of Methotrexate Varying in Their Molecular Weight from MW 750 to MW 40000:  Synthesis, Characterization, and Structure−Activity Relationships in Vitro and in Vivo by Riebeseel, Katja, Biedermann, Elfi, Löser, Roland, Breiter, Norbert, Hanselmann, Ralf, Mülhaupt, Rolf, Unger, Clemens, Kratz, Felix

“…Poly(ethylene glycol)s (PEGs) are potential drug carriers for improving the therapeutic index of anticancer agents. In this work, the anticancer drug…”
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Preclinical data for Droloxifene by Hasmann, M, Rattel, B, Löser, R

“…The new antiestrogen Droloxifene has a 10-60-fold higher binding affinity to the estrogen receptor (ER) compared to the related compound Tamoxifen. A similar…”
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In vivo and in vitro antiestrogenic action of 3-hydroxytamoxifen, tamoxifen and 4-hydroxytamoxifen by Löser, R, Seibel, K, Roos, W, Eppenberger, U

“…This study demonstrates in vivo and in vitro properties of the non-steroidal antiestrogens tamoxifen (TAM), 4-OH-tamoxifen (4-OH-TAM) and 3-OH-tamoxifen (K 060…”
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Inhibition of growth-factor-activated proliferation by anti-estrogens and effects on early gene expression of MCF-7 cells by Wosikowski, K, Küng, W, Hasmann, M, Löser, R, Eppenberger, U

“…Recently, it was reported that the anti-estrogen tamoxifen not only inhibits estradiol-stimulated growth of MCF-7 cells but also significantly reduces the…”
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Effects of pravastatin on cholesterol metabolism of cholesterol‐fed heterozygous WHHL rabbits by Harsch, Michael, Gebhardt, Angelika, Reymann, Andreas, Lang, Gerhard, Schliack, Michael, Löser, Roland, Hinrich Braesen, Jan, Niendorf, Axel

“…We administered the 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitor pravastatin at a daily dose of 1 mg kg−1 body weight to cholesterol‐fed (0.03%)…”
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Antiestrogenic action of 3-hydroxytamoxifen in the human breast cancer cell line MCF-7 by Roos, W, Oeze, L, Löser, R, Eppenberger, U

“…The antiestrogenic action of 3-hydroxytamoxifen [trans-1-(4-beta-dimethylaminoethoxyphenyl)-1-(3-hydroxyphenyl)-2 -phenylbut-1-ene] was characterized in vitro…”
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Circadian variation of the hypocholesterolemic effect of K13.004 in rats by Schliack, M, Löser, R, Seibel, K

“…The hypocholesterolemic effect in rats of the new lipid-lowering agent K13.004 was dependent on the time of day of its application. This dependence was shifted…”
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Effect of continuous vs intermittent application of 3-OH-tamoxifen or tamoxifen on the proliferation of the human breast cancer cell line MCF-7 M1 by DIETEL, M, LÖSER, R, RÖHLKE, P, JONAT, W, NIENDORF, A, GERDING, D, KOHR, A, HÖLZEL, F, ARPS, H

“…The antiproliferative potency of 5 x 10(-7) M tamoxifen (TAM) and 3-hydroxytamoxifen (3-OH-TAM) was investigated during continuous (8 days) or intermittent (2…”
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