Search Results - "LORRAIN, D. S"

Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist by Swaney, J S, Chapman, C, Correa, L D, Stebbins, K J, Broadhead, A R, Bain, G, Santini, A M, Darlington, J, King, C D, Baccei, C S, Lee, C, Parr, T A, Roppe, J R, Seiders, T J, Ziff, J, Prasit, P, Hutchinson, J H, Evans, J F, Lorrain, D S

“…Lysophosphatidic acid (LPA) is a bioactive phospholipid that signals through a family of at least six G protein-coupled receptors designated LPA₁₋₆. LPA type 1…”
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Effects of ketamine and n-methyl- d-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268 by Lorrain, D.S, Baccei, C.S, Bristow, L.J, Anderson, J.J, Varney, M.A

“…Previous studies have shown that the metabotropic glutamate receptor (mGluR)2/3 agonist LY354740 attenuated glutamate release in medial prefrontal cortex…”
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Pharmacodynamics and Pharmacokinetics of AM103, a Novel Inhibitor of 5-Lipoxygenase-Activating Protein ( ) by Bain, G, King, C D, Rewolinski, M, Schaab, K, Santini, A M, Shapiro, D, Moran, M, Wetering de Rooij, S, Roffel, A F, Schuilenga‐Hut, P, Milne, G L, Lorrain, D S, Li, Y, Arruda, J M, Hutchinson, J H, Prasit, P, Evans, J F

“…The 5‐lipoxygenase‐activating protein (FLAP) gene and an increase in leukotriene (LT) production are linked to the risk of asthma, myocardial infarction, and…”
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Previous exposure to amphetamine increases incentive to obtain the drug: long-lasting effects revealed by the progressive ratio schedule by Lorrain, D.S, Arnold, G.M, Vezina, P

“…The present experiment tested whether previous exposure to amphetamine would enhance rats’ predisposition to self-administer a high dose of the drug under…”
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A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model by Swaney, J S, Chapman, C, Correa, L D, Stebbins, K J, Bundey, R A, Prodanovich, P C, Fagan, P, Baccei, C S, Santini, A M, Hutchinson, J H, Seiders, T J, Parr, T A, Prasit, P, Evans, J F, Lorrain, D S

“…The aim of this study was to assess the potential of an antagonist selective for the lysophosphatidic acid receptor, LPA(1), in treating lung fibrosis We…”
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Extracellular dopamine in the medial preoptic area: implications for sexual motivation and hormonal control of copulation by Hull, EM, Du, J, Lorrain, DS, Matuszewich, L

“…Dopamine (DA) activity in the medial preoptic area (MPOA) contributes to the control of male rat sexual behavior. We tested (1) whether extracellular DA…”
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The effect of previous exposure to amphetamine on drug-induced locomotion and self-administration of a low dose of the drug by VEZINA, Paul, PIERRE, Peter J, LORRAIN, Daniel S

“…In order to assess directly the relationship between locomotor activity and drug self-administration, the present experiment simultaneously measured these two…”
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A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model by Swaney, JS, Chapman, C, Correa, LD, Stebbins, KJ, Bundey, RA, Prodanovich, PC, Fagan, P, Baccei, CS, Santini, AM, Hutchinson, JH, Seiders, TJ, Parr, TA, Prasit, P, Evans, JF, Lorrain, DS

“…Background and purpose:  The aim of this study was to assess the potential of an antagonist selective for the lysophosphatidic acid receptor, LPA1, in treating…”
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Dopamine Release in the Medial Preoptic Area of Female Rats in Response to Hormonal Manipulation and Sexual Activity by Matuszewich, Leslie, Lorrain, Daniel S, Hull, Elaine M

“…Dopamine (DA) is responsive to hormonal manipulations and has been implicated in the regulation of female rat sexual behavior. In the present studies,…”
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A novel, orally active LPA 1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model by Swaney, JS, Chapman, C, Correa, LD, Stebbins, KJ, Bundey, RA, Prodanovich, PC, Fagan, P, Baccei, CS, Santini, AM, Hutchinson, JH, Seiders, TJ, Parr, TA, Prasit, P, Evans, JF, Lorrain, DS

“…Background and purpose:  The aim of this study was to assess the potential of an antagonist selective for the lysophosphatidic acid receptor, LPA 1 , in…”
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The roles of nitric oxide in sexual function of male rats by Hull, E M, Lumley, L A, Matuszewich, L, Dominguez, J, Moses, J, Lorrain, D S

“…Nitric oxide (NO) may mediate penile erection by inhibiting smooth muscle of the corpora cavernosa, thereby allowing vasodilation of the corpora. In order to…”
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Testosterone, Preoptic Dopamine, and Copulation in Male Rats by Hull, Elaine M, Du, Jianfang, Lorrain, Daniel S, Matuszewich, Leslie

“…Steroid hormones prime neural circuits for sexual behavior, in part by regulating enzymes, receptors, or other proteins affecting neurotransmitter function…”
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Nitric oxide promotes medial preoptic dopamine release during male rat copulation by Lorrain, Daniel S, Matuszewich, Leslie, Howard, Ryan V, Du, Jianfang, Hull, Elaine M

“…DOPAMINE (DA) is released in the medial preoptic area (MPOA) of male rats during copulation. DA agonists infused into the MPOA facilitate, and antagonists…”
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The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. III: The mechanistic basis for supersensitivity to the LSD stimulus following serotonin depletion by FIORELLA, D, HELSLEY, S, LORRAIN, D. S, RABIN, R. A, WINTER, J. C

“…The present study was designed to determine the effects of p-chlorophenylalanine (PCPA) and p-chloroamphetamine (PCA) administration on (1) the levels of…”
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Castration decreases extracellular, but increases intracellular, dopamine in medial preoptic area of male rats by Du, Jianfang, Lorrain, Daniel S, Hull, Elaine M

“…Dopamine (DA) is released in the medial preoptic area (MPOA) of male rats in the presence of a female, and it facilitates male sexual behavior. Castration…”
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8-OH-DPAT influences extracellular levels of serotonin and dopamine in the medial preoptic area of male rats by Lorrain, Daniel S., Matuszewich, Leslie, Hull, Elaine M.

“…Serotonin (5-HT) is generally inhibitory to male rat sexual behavior. However, the 5-HT 1A agonist 8-hydroxy-di-propylaminotetralin (8-OH-DPAT), injected…”
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Sensitization of Midbrain Dopamine Neuron Reactivity Promotes the Pursuit of Amphetamine by Vezina, Paul, Lorrain, Daniel S, Arnold, Gretchen M, Austin, Jennifer D, Suto, Nobuyoshi

“…Stimulant drugs such as amphetamine are readily self-administered by humans and laboratory animals by virtue of their actions on dopamine (DA) neurons of the…”
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Effects of morphiceptin in the medial preoptic area on male sexual behavior by MATUSZEWICH, L, ORMSBY, J. L, MOSES, J, LORRAIN, D. S, HULL, E. M

“…Morphiceptin, a selective mu opioid agonist, injected into the medial preoptic area (MPOA), delayed the onset of copulation in male rats, but did not affect…”
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Lateral Hypothalamic Serotonin Inhibits Nucleus Accumbens Dopamine: Implications for Sexual Satiety by Lorrain, Daniel S, Riolo, Jon V, Matuszewich, Leslie, Hull, Elaine M

“…Dopamine (DA) is released in several brain areas, including the nucleus accumbens (NAcc), before and during copulation in male rats. DA agonists administered…”
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Nitric oxide increases dopamine and serotonin release in the medial preoptic area by Lorrain, D S, Hull, E M

“…Nitric oxide (NO) is becoming recognized as an important intercellular messenger in the brain. The present experiment used microdialysis to examine the…”
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