Search Results - "LORGE, Elisabeth"

Comparison of different cytotoxicity measurements for the in vitro micronucleus assay using L5178Y and TK6 cells in support of OECD draft Test Guideline 487 by Lorge, Elisabeth

“…The reference genotoxic agents mitomycin C, cadmium chloride, 2-aminoanthracene, vinblastine sulphate and 5-fluorouracil were tested in the in vitro…”
Get full text

Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay by Bryce, Steven M., Bernacki, Derek T., Bemis, Jeffrey C., Spellman, Richard A., Engel, Maria E., Schuler, Maik, Lorge, Elisabeth, Heikkinen, Pekka T., Hemmann, Ulrike, Thybaud, Véronique, Wilde, Sabrina, Queisser, Nina, Sutter, Andreas, Zeller, Andreas, Guérard, Melanie, Kirkland, David, Dertinger, Stephen D.

“…We previously described a multiplexed in vitro genotoxicity assay based on flow cytometric analysis of detergent‐liberated nuclei that are simultaneously…”
Get full text

Main issues addressed in the 2014–2015 revisions to the OECD Genetic Toxicology Test Guidelines by Thybaud, Veronique, Lorge, Elisabeth, Levy, Dan D., Benthem, Jan, Douglas, George R., Marchetti, Francesco, Moore, Martha M., Schoeny, Rita, Gibbons, Catherine

“…The Organization for Economic Cooperation and Development (OECD) recently revised the test guidelines (TGs) for genetic toxicology. This article describes the…”
Get full text

Relationships between p53 status, apoptosis and induction of micronuclei in different human and mouse cell lines in vitro: Implications for improving existing assays by Whitwell, James, Smith, Robert, Jenner, Karen, Lyon, Heather, Wood, Deborah, Clements, Julie, Aschcroft-Hawley, Kelly, Gollapudi, Bhaskar, Kirkland, David, Lorge, Elisabeth, Pfuhler, Stefan, Tanir, Jennifer Y., Thybaud, Veronique

“…•p53 competent and p53-mutant human and mouse cell lines compared for MN induction.•9 chemicals previously shown to produce misleading positive results were…”
Get full text

Report from the in vitro micronucleus assay working group by Kirsch-Volders, Micheline, Sofuni, Toshio, Aardema, Marilyn, Albertini, Silvio, Eastmond, David, Fenech, Michael, Ishidate, Motoi, Kirchner, Stephan, Lorge, Elisabeth, Morita, Takeshi, Norppa, Hannu, Surrallés, Jordi, Vanhauwaert, Annelies, Wakata, Akihiro

“…At the Washington “2nd International Workshop on Genotoxicity Testing” (25–26 March 1999) current methodologies and data for the in vitro micronucleus test…”
Get full text

Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part II: Performances of the In Vitro Micronucleus Test Compared to the Mouse Lymphoma Assay and the In Vitro Chromosome Aberration Assay by Lorge, Elisabeth, Lambert, Carine, Gervais, Véronique, Becourt-Lhote, Nathalie, Delongeas, Jean-Luc, Claude, Nancy

“…The in vitro micronucleus test is commonly used in the early stages of pharmaceutical development as a predictive tool for the regulatory mouse lymphoma assay…”
Get full text

Report from the In Vitro Micronucleus Assay Working Group by Kirsch-Volders, Micheline, Sofuni, Toshio, Aardema, Marilyn, Albertini, Silvio, Eastmond, David, Fenech, Michael, Ishidate Jr, Motoi, Lorge, Elisabeth, Norppa, Hannu, Surrallés, Jordi, von der Hude, Wilhelm, Wakata, Akihiro

“…At the Washington International Workshop on Genotoxicity Test Procedures (March 25–26, 1999), the current methodologies and data for the in vitro micronucleus…”
Get full text

Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test by Fellows, Michael D., O’Donovan, Michael R., Lorge, Elisabeth, Kirkland, David

“…Appropriate measures of cytotoxicity need to be used when selecting test concentrations in in vitro genotoxicity assays. Underestimation of toxicity may lead…”
Get full text

SFTG international collaborative study on in vitro micronucleus test by Aardema, Marilyn J., Snyder, Ronald D., Spicer, Carol, Divi, Katyayini, Morita, Takeshi, Mauthe, Robert J., Gibson, David P., Soelter, Sandra, Curry, Patrick T., Thybaud, Veronique, Lorenzon, Giocondo, Marzin, Daniel, Lorge, Elisabeth

“…In this report, results are presented from an international study of the in vitro micronucleus assay using Chinese hamster ovary cells. This study was…”
Get full text

SFTG international collaborative study on in vitro micronucleus test by Clare, M. Gillian, Lorenzon, Giocondo, Akhurst, Leslie C., Marzin, Daniel, van Delft, Joost, Montero, Regina, Botta, Alain, Bertens, Arma, Cinelli, Serena, Thybaud, Véronique, Lorge, Elisabeth

“…This study on the in vitro micronucleus assay, comprising 11 laboratories using human lymphocytes, was coordinated by an organizing committee supported by the…”
Get full text

Comparison of different cytotoxicity measurements for the in vitro micronucleus assay using L5178Y and TK6 cells in support of OECD draft Test Guideline 487: Cytotoxicity Measures in the In Vitro Micronucleus Test by LORGE, Elisabeth

Get full text

Corrigendum to “Report from the in vitro micronucleus assay working group” [Mutat. Res. 540 (2003) 153–163] by Kirsch-Volders, Micheline, Sofuni, Toshio, Aardema, Marilyn, Albertini, Silvio, Eastmond, David, Fenech, Michael, Ishidate, Motoi, Kirchner, Stephan, Lorge, Elisabeth, Morita, Takeshi, Norppa, Hannu, Surrallés, Jordi, Vanhauwaert, Annelies, Wakata, Akihiro

Get full text

Tungsten carbide-cobalt as a nanoparticulate reference positive control in in vitro genotoxicity assays by Moche, Hélène, Chevalier, Dany, Barois, Nicolas, Lorge, Elisabeth, Claude, Nancy, Nesslany, Fabrice

“…With the increasing human exposure to nanoparticles (NP), the evaluation of their genotoxic potential is of significant importance. However, relevance for NP…”
Get full text

Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test II. Practical aspects with toxic agents by FELLOWS, Michael D, O'DONOVAN, Michael R, LORGE, Elisabeth, KIRKLAND, David

“…Appropriate measures of cytotoxicity need to be used when selecting test concentrations in in vitro genotoxicity assays. Underestimation of toxicity may lead…”
Get full text

An adaptation of the human HepaRG cells to the in vitro micronucleus assay by JOSSE, Rozenn, ROGUE, Alexandra, LORGE, Elisabeth, GUILLOUZO, André

“…The in vitro micronucleus test is considered as an attractive tool for genotoxicity testing of chemicals because of its simplicity of scoring and wide…”
Get full text

Workshop summary: Top concentration for in vitro mammalian cell genotoxicity assays; and report from working group on toxicity measures and top concentration for in vitro cytogenetics assays (chromosome aberrations and micronucleus) by Galloway, Sheila, Lorge, Elisabeth, Aardema, Marilyn J., Eastmond, David, Fellows, Mick, Heflich, Robert, Kirkland, David, Levy, Dan D., Lynch, Anthony M., Marzin, Daniel, Morita, Takeshi, Schuler, Maik, Speit, Günter

“…The selection of maximum concentrations for in vitro mammalian cell genotoxicity assays was reviewed at the 5th International Workshop on Genotoxicity Testing…”
Get full text

Genotoxicity of tungsten carbide–cobalt (WC–Co) nanoparticles in vitro: Mechanisms-of-action studies by Moche, Hélène, Chevalier, Dany, Vezin, Hervé, Claude, Nancy, Lorge, Elisabeth, Nesslany, Fabrice

“…•WC–Co NP induce structural and numerical chromosome aberrations.•FISH analysis of micronuclei shows the induction of clastogenic and aneugenic events.•WC–Co…”
Get full text

SFTG international collaborative study on in vitro micronucleus test I. General conditions and overall conclusions of the study by Lorge, Elisabeth, Thybaud, Veronique, Aardema, Marilyn J, Oliver, Jo, Wakata, Akihiro, Lorenzon, Giocondo, Marzin, Daniel

“…This study, coordinated by the SFTG (French branch of European Environmental Mutagen Society), included 38 participants from Europe, Japan and America…”
Get full text

Follow-up actions from positive results of in vitro genetic toxicity testing by Dearfield, Kerry L, Thybaud, Véronique, Cimino, Michael C, Custer, Laura, Czich, Andreas, Harvey, James S, Hester, Susan, Kim, James H, Kirkland, David, Levy, Dan D, Lorge, Elisabeth, Moore, Martha M, Ouédraogo-Arras, Gladys, Schuler, Maik, Suter, Willi, Sweder, Kevin, Tarlo, Kirk, van Benthem, Jan, van Goethem, Freddy, Witt, Kristine L

“…Appropriate follow-up actions and decisions are needed when evaluating and interpreting clear positive results obtained in the in vitro assays used in the…”
Get full text

SFTG international collaborative study on in vitro micronucleus test II. Using human lymphocytes by Clare, M Gillian, Lorenzon, Giocondo, Akhurst, Leslie C, Marzin, Daniel, van Delft, Joost, Montero, Regina, Botta, Alain, Bertens, Arma, Cinelli, Serena, Thybaud, Véronique, Lorge, Elisabeth

“…This study on the in vitro micronucleus assay, comprising 11 laboratories using human lymphocytes, was coordinated by an organizing committee supported by the…”
Get full text