Search Results - "LORD, C"

Cardiac fibroblast-dependent extracellular matrix accumulation is associated with diastolic stiffness in type 2 diabetes by Hutchinson, Kirk R, Lord, C Kevin, West, T Aaron, Stewart, Jr, James A

“…Cardiovascular complications are a leading cause of death in patients with type 2 diabetes mellitus (T2DM). Diastolic dysfunction is one of the earliest…”
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ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer by Miller, R.E., Leary, A., Scott, C.L., Serra, V., Lord, C.J., Bowtell, D., Chang, D.K., Garsed, D.W., Jonkers, J., Ledermann, J.A., Nik-Zainal, S., Ray-Coquard, I., Shah, S.P., Matias-Guiu, X., Swisher, E.M., Yates, L.R.

“…Homologous recombination repair deficiency (HRD) is a frequent feature of high-grade serous ovarian, fallopian tube and peritoneal carcinoma (HGSC) and is…”
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The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C by Lord, Caleb C, Wyler, Steven C, Wan, Rong, Castorena, Carlos M, Ahmed, Newaz, Mathew, Dias, Lee, Syann, Liu, Chen, Elmquist, Joel K

“…Atypical antipsychotics such as olanzapine often induce excessive weight gain and type 2 diabetes. However, the mechanisms underlying these drug-induced…”
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Pathways of spread in rectal cancer: a reappraisal of the true routes to distant metastatic disease by Lord, Amy C., Knijn, Nikki, Brown, Gina, Nagtegaal, Iris D.

“…Rectal cancer can spread in a number of ways which have been previously recognised and validated as prognostic markers. These routes of spread are not…”
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Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism by Lord, Caleb C., Thomas, Gwynneth, Brown, J. Mark

“…Dysregulation of lipid metabolism underlies many chronic diseases such as obesity, diabetes, cardiovascular disease, and cancer. Therefore, understanding…”
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Identification of blade operational mode shapes during wear of abradable coating by Tang, N., Zhang, B., Lord, C., Marshall, M.

“…Abradable liner materials are often used in turbine engines between the compressor blade tips and the casing. The abradable liner serves as a partially…”
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Neurological Complications of COVID-19: Underlying Mechanisms and Management by Shehata, Ghaydaa A, Lord, Kevin C, Grudzinski, Michaela C, Elsayed, Mohamed, Abdelnaby, Ramy, Elshabrawy, Hatem A

“…COVID-19 is a severe respiratory disease caused by the newly identified human coronavirus (HCoV) Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)…”
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Prognostic Importance of MRI-Detected Extramural Venous Invasion in Rectal Cancer: A Literature Review and Systematic Meta-Analysis by Tan, Jessica Juliana, Carten, Rachel V., Babiker, Amna, Abulafi, Muti, Lord, Amy C., Brown, Gina

“…Extramural venous invasion (EMVI) is recognized as a poor prognostic factor in rectal cancer. There are well-documented limitations associated with pathology…”
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Change in knee flexor torque after fatiguing exercise identifies previous hamstring injury in football players by Lord, C., Ma'ayah, F., Blazevich, A. J.

“…Muscular fatigue and interlimb strength asymmetry are factors known to influence hamstring injury risk; however, limb‐specific exacerbation of knee flexor…”
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Inhibition of GPX4 enhances CDK4/6 inhibitor and endocrine therapy activity in breast cancer by Herrera-Abreu, M. T., Guan, J., Khalid, U., Ning, J., Costa, M. R., Chan, J., Li, Q., Fortin, J-P., Wong, W. R., Perampalam, P., Biton, A., Sandoval, W., Vijay, J., Hafner, M., Cutts, R., Wilson, G., Frankum, J., Roumeliotis, T. I., Alexander, J., Hickman, O., Brough, R., Haider, S., Choudhary, J., Lord, C. J., Swain, A., Metcalfe, C., Turner, N. C.

“…CDK4/6 inhibition in combination with endocrine therapy is the standard of care for estrogen receptor (ER+) breast cancer, and although cytostasis is…”
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Learning model discrepancy: A Gaussian process and sampling-based approach by Gardner, P., Rogers, T.J., Lord, C., Barthorpe, R.J.

“…•A new GP regression and importance sampling method for inferring model discrepancy.•A new decoupled two stage process for calibration and model discrepancy…”
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Bayesian history matching for structural dynamics applications by Gardner, P., Lord, C., Barthorpe, R.J.

“…•A novel combined Bayesian history matching and Gaussian Process regression approach for calibrating computer models, whilst accounting for model discrepancy,…”
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Can extranodal tumour deposits be diagnosed on MRI? Protocol for a multicentre clinical trial (the COMET trial) by Lord, Amy C, Moran, Brendan, Abulafi, Muti, Rasheed, Shahnawaz, Nagtegaal, Iris D, Terlizzo, Monica, Brown, Gina

“…IntroductionTumour deposits (TDs) are a poor prognostic marker when seen on pathology, and are worse than lymph node metastases (LNMs). They are now being…”
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Serotonergic Control of Metabolic Homeostasis by Wyler, Steven C, Lord, Caleb C, Lee, Syann, Elmquist, Joel K, Liu, Chen

“…New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin…”
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Functional Electrical Stimulation for Foot Drop in Multiple Sclerosis: A Systematic Review and Meta-Analysis of the Effect on Gait Speed by Miller, Linda, MPhil, McFadyen, Angus, PhD, Lord, Anna C., MSc, Hunter, Rebecca, BSc, Paul, Lorna, PhD, Rafferty, Danny, Bowers, Roy, Mattison, Paul, MD

“…Abstract Objective To review the efficacy of functional electrical stimulation (FES) used for foot drop in people with multiple sclerosis (pwMS) on gait speed…”
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Is the type of insufflation a key issue in gastro-intestinal endoscopy? by Lord, Amy C, Riss, Stefan

“…Endoscopic procedures continue to play an emerging role in diagnosing and treating upper and lower gastrointestinal(GI)disorders.In particular,the introduction…”
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POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels by Caron, Alexandre, Dungan Lemko, Heather M, Castorena, Carlos M, Fujikawa, Teppei, Lee, Syann, Lord, Caleb C, Ahmed, Newaz, Lee, Charlotte E, Holland, William L, Liu, Chen, Elmquist, Joel K

“…Leptin is critical for energy balance, glucose homeostasis, and for metabolic and neuroendocrine adaptations to starvation. A prevalent model predicts that…”
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Correction: A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D by Rayter, S., Elliott, R., Travers, J., Rowlands, M. G., Richardson, T. B., Boxall, K., Jones, K., Linardopoulos, S., Workman, P., Aherne, W., Lord, C. J., Ashworth, A.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Transmission risk of two chikungunya lineages by invasive mosquito vectors from Florida and the Dominican Republic by Alto, Barry W, Wiggins, Keenan, Eastmond, Bradley, Velez, Daniel, Lounibos, L Philip, Lord, Cynthia C

“…Between 2014 and 2016 more than 3,800 imported human cases of chikungunya fever in Florida highlight the high risk for local transmission. To examine the…”
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A decade of clinical development of PARP inhibitors in perspective by Mateo, J., Lord, C.J., Serra, V., Tutt, A., Balmaña, J., Castroviejo-Bermejo, M., Cruz, C., Oaknin, A., Kaye, S.B., de Bono, J.S.

“…Genomic instability is a hallmark of cancer, and often is the result of altered DNA repair capacities in tumour cells. DNA damage repair defects are common in…”
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