Search Results - "LORCA, Sabina"

Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats by Li, Jiahe, Stratton, Harrison J, Lorca, Sabina A, Grace, Peter M, Khanna, Rajesh

“…The voltage-gated sodium channel isoform NaV1.7 is a critical player in the transmission of nociceptive information. This channel has been heavily implicated…”
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Preconditioning by voluntary wheel running attenuates later neuropathic pain via nuclear factor E2–related factor 2 antioxidant signaling in rats by Green-Fulgham, Suzanne M., Harland, Michael E., Ball, Jayson B., Li, Jiahe, Lacagnina, Michael J., D'Angelo, Heather, Dreher, Renee A., Willcox, Kendal F., Lorca, Sabina A., Kwilasz, Andrew J., Maier, Steven F., Watkins, Linda R., Grace, Peter M.

“…Animal and human studies have shown that exercise prior to nerve injury prevents later chronic pain, but the mechanisms of such preconditioning remain elusive…”
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Muscle Arnt/Hif1β Is Dispensable in Myofiber Type Determination, Vascularization and Insulin Sensitivity by Badin, Pierre-Marie, Sopariwala, Danesh H, Lorca, Sabina, Narkar, Vihang A

“…Aryl Hydrocarbon Receptor Nuclear Translocator/ hypoxia-inducible factor 1 beta (ARNT/ HIF1β), a member of bHLH-PAS family of transcriptional factors, plays a…”
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PGC1β Activates an Antiangiogenic Program to Repress Neoangiogenesis in Muscle Ischemia by Yadav, Vikas, Matsakas, Antonios, Lorca, Sabina, Narkar, Vihang A.

“…Revascularization of ischemic skeletal muscle is governed by a balance between pro- and antiangiogenic factors in multiple cell types but particularly in…”
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Ligands for FKBP12 Increase Ca2+ Influx and Protein Synthesis to Improve Skeletal Muscle Function by Lee, Chang Seok, Georgiou, Dimitra K., Dagnino-Acosta, Adan, Xu, Jianjun, Ismailov, Iskander I., Knoblauch, Mark, Monroe, Tanner O., Ji, RuiRui, Hanna, Amy D., Joshi, Aditya D., Long, Cheng, Oakes, Joshua, Tran, Ted, Corona, Benjamin T., Lorca, Sabina, Ingalls, Christopher P., Narkar, Vihang A., Lanner, Johanna T., Bayle, J. Henri, Durham, William J., Hamilton, Susan L.

“…Rapamycin at high doses (2–10 mg/kg body weight) inhibits mammalian target of rapamycin complex 1 (mTORC1) and protein synthesis in mice. In contrast, low…”
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Muscle ERRγ mitigates Duchenne muscular dystrophy via metabolic and angiogenic reprogramming by Matsakas, Antonios, Yadav, Vikas, Lorca, Sabina, Narkar, Vihang

“…Treatment of Duchenne muscular dystrophy (DMD) by replacing mutant dystrophin or restoring dystrophin‐associated glycoprotein complex (DAG) has been clinically…”
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Oral Dimethyl Fumarate Reduces Peripheral Neuropathic Pain in Rodents via NFE2L2 Antioxidant Signaling by Li, Jiahe, Ma, Jiacheng, Lacagnina, Michael J., Lorca, Sabina, Odem, Max A., Walters, Edgar T., Kavelaars, Annemieke, Grace, Peter M.

“…WHAT WE ALREADY KNOW ABOUT THIS TOPICOxidative stress is an important driver of neuropathic painDimethyl fumarate activates nuclear factor erythroid 2-related…”
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Oral Dimethyl Fumarate Reduces Peripheral Neuropathic Pain in Rodents via NFE2L2 Antioxidant Signaling by Li, Jiahe, Ma, Jiacheng, Lacagnina, Michael J, Lorca, Sabina, Odem, Max A, Walters, Edgar T, Kavelaars, Annemieke, Grace, Peter M

“…Available treatments for neuropathic pain have modest efficacy and significant adverse effects, including abuse potential. Because oxidative stress is a key…”
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A role for neuroimmune signaling in a rat model of Gulf War Illness-related pain by Lacagnina, Michael J., Li, Jiahe, Lorca, Sabina, Rice, Kenner C., Sullivan, Kimberly, O'Callaghan, James P., Grace, Peter M.

“…•A neuroinflammatory basis for pain associated with GWI has not been investigated.•Combination Gulf War-relevant exposures induce long-lasting musculoskeletal…”
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Loss of Estrogen-Related Receptor Alpha Facilitates Angiogenesis in Endothelial Cells by Likhite, Neah, Yadav, Vikas, Milliman, Eric J., Sopariwala, Danesh H., Lorca, Sabina, Narayana, Nithya P., Sheth, Megha, Reineke, Erin L., Giguère, Vincent, Narkar, Vihang

“…Estrogen-related receptors (ERRs) have emerged as major metabolic regulators in various tissues. However, their expression and function in the vasculature…”
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Preconditioning by voluntary wheel running attenuates later neuropathic pain via Nrf2 antioxidant signaling in rats by Green-Fulgham, Suzanne M., Harland, Michael E., Ball, Jayson B., Li, Jiahe, Lacagnina, Michael J., D’Angelo, Heather, Dreher, Renee A., Willcox, Kendal F., Lorca, Sabina A., Kwilasz, Andrew J., Maier, Steven F., Watkins, Linda R., Grace, Peter M.

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Exercise and PGC-1α-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERRγ by Narkar, Vihang A., Fan, Weiwei, Downes, Michael, Yu, Ruth T., Jonker, Johan W., Alaynick, William A., Banayo, Ester, Karunasiri, Malith S., Lorca, Sabina, Evans, Ronald M.

“…How type I skeletal muscle inherently maintains high oxidative and vascular capacity in the absence of exercise is unclear. We show that nuclear receptor ERRγ…”
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Revascularization of Ischemic Skeletal Muscle by Estrogen-Related Receptor-γ by Matsakas, Antonios, Yadav, Vikas, Lorca, Sabina, Evans, Ronald M, Narkar, Vihang A

“…RATIONALE:Oxidative myofibers in the skeletal muscles express high levels of angiogenic factors, have dense vasculature, and promptly revascularize during…”
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Muscle Arnt/Hif1[beta] Is Dispensable in Myofiber Type Determination, Vascularization and Insulin Sensitivity by Badin, Pierre-Marie, Sopariwala, Danesh H, Lorca, Sabina, Narkar, Vihang A

“…Aryl Hydrocarbon Receptor Nuclear Translocator/ hypoxia-inducible factor 1 beta (ARNT/ HIF1[beta]), a member of bHLH-PAS family of transcriptional factors,…”
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Long-term PGC1β overexpression leads to apoptosis, autophagy and muscle wasting by Sopariwala, Danesh H., Yadav, Vikas, Badin, Pierre-Marie, Likhite, Neah, Sheth, Megha, Lorca, Sabina, Vila, Isabelle K., Kim, Eun Ran, Tong, Qingchun, Song, Min Sup, Rodney, George G., Narkar, Vihang A.

“…Skeletal muscle wasting is prevalent in many chronic diseases, necessitating inquiries into molecular regulation of muscle mass. Nuclear receptor co-activator…”
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Exercise-like effects by Estrogen-related receptor-gamma in muscle do not prevent insulin resistance in db/db mice by Badin, Pierre-Marie, Vila, Isabelle K., Sopariwala, Danesh H., Yadav, Vikas, Lorca, Sabina, Louche, Katie, Kim, Eun Ran, Tong, Qingchun, Song, Min Sup, Moro, Cedric, Narkar, Vihang A.

“…Dissecting exercise-mimicking pathways that can replicate the benefits of exercise in obesity and diabetes may lead to promising treatments for metabolic…”
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Revascularization of Ischemic Skeletal Muscle by Estrogen-Related Receptor-y by MATSAKAS, Antonios, YADAV, Vikas, LORCA, Sabina, EVANS, Ronald M, NARKAR, Vihang A

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Exercise and PGC1α-independent Synchronization of Type I Muscle Metabolism and Vasculature by ERRγ by Narkar, Vihang A., Fan, Weiwei, Downes, Michael, Yu, Ruth T., Jonker, Johan W., Alaynick, William A., Banayo, Ester, Karunasiri, Malith S., Lorca, Sabina, Evans, Ronald M.

“…How type I skeletal muscle inherently maintains high oxidative and vascular capacity in absence of exercise in unclear. We show that nuclear receptor ERRγ is…”
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Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats by Li, Jiahe, Stratton, Harrison J., Lorca, Sabina A., Grace, Peter M., Khanna, Rajesh

“…The voltage-gated sodium channel isoform NaV1.7 is a critical player in the transmission of nociceptive information. This channel has been heavily implicated…”
Get full text