Search Results - "LORBER, Marc I"

Intra‐bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to >60 days and promotes increased porcine lung transplant survival by Watanabe, Hironosuke, Ariyoshi, Yuichi, Pomposelli, Thomas, Takeuchi, Kazuhiro, Ekanayake‐Alper, Dilrukshi K., Boyd, Lennan K., Arn, Scott J., Sahara, Hisashi, Shimizu, Akira, Ayares, David, Lorber, Marc I., Sykes, Megan, Sachs, David H., Yamada, Kazuhiko

“…Background We have recently demonstrated that human‐CD47 (hCD47) expressed on endothelial cells of porcine lung xenografts extended median graft survival from…”
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Everolimus versus mycophenolate mofetil in the prevention of rejection in de novo renal transplant recipients : A 3-year randomized, multicenter, phase III study by LORBER, Marc I, MULGAONKAR, Shamkant, TEDESCO, Helio, BUTT, Khalid M. H, ELKHAMMAS, Elmahdi, MENDEZ, Robert, RAJAGOPALAN, P. R, KAHAN, Barry, SOLLINGER, Hans, YULAN LI, CRETIN, Nathalie

“…This 36-month, randomized, parallel-group study compared safety and efficacy of two doses of everolimus with mycophenolate mofetil (MMF) in de novo…”
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Engraftment of a vascularized human skin equivalent by Schechner, Jeffrey S., Crane, Saara K., Wang, Feiya, Szeglin, Anya M., Tellides, George, Lorber, Marc I., Bothwell, Alfred L. M., Pober, Jordan S.

“…ABSTRACT Clinical performance of currently avail able human skin equivalents is limited by failure to develop perfusion. To address this problem we have…”
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Therapeutic drug monitoring for everolimus in kidney transplantation using 12-month exposure, efficacy, and safety data by Lorber, Marc I, Ponticelli, Claudio, Whelchel, John, Mayer, Hartmut W, Kovarik, John, Li, Yulan, Schmidli, Heinz

“…:  The aims of the current study were to determine whether therapeutic drug monitoring (TDM) might benefit kidney transplant recipients receiving everolimus,…”
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The role of industry in advancing xenotransplantation by Shin, Jordan T., Rothblatt, Martine A., Lorber, Marc I.

“…Xenotransplantation offers the opportunity to alleviate the imbalance between the demand of patients with end stage organ failure and the supply of organs…”
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GalT‐KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels by Watanabe, Hironosuke, Sahara, Hisashi, Nomura, Shunichiro, Tanabe, Tatsu, Ekanayake‐Alper, Dilrukshi K., Boyd, Lennan K., Louras, Nathan J., Asfour, Arsenoi, Danton, Makenzie A., Ho, Siu‐Hong, Arn, Scott J., Hawley, Robert J., Shimizu, Akira, Nagayasu, Takeshi, Ayares, David, Lorber, Marc I., Sykes, Megan, Sachs, David H., Yamada, Kazuhiko

“…Background Despite recent progress in survival times of xenografts in non‐human primates, there are no reports of survival beyond 5 days of histologically…”
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T cell-mediated vascular dysfunction of human allografts results from IFN-gamma dysregulation of NO synthase by Koh, Kian Peng, Wang, Yinong, Yi, Tai, Shiao, Stephen L, Lorber, Marc I, Sessa, William C, Tellides, George, Pober, Jordan S

“…Allograft vascular dysfunction predisposes to arteriosclerosis and graft loss. We examined how dysfunction develops in transplanted human arteries in response…”
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Peroxisome Proliferator―Activated Receptor-γ Agonists Prevent In Vivo Remodeling of Human Artery Induced by Alloreactive T Cells by TOBIASOVA, Zuzana, LUFENG ZHANG, POBER, Jordan S, KAWIKOVA, Ivana, BOTHWELL, Alfred L. M, TAI YI, LINFENG QIN, MANES, Thomas D, KULKARNI, Sanjay, LORBER, Marc I, RODRIGUEZ, Frederick C, CHOI, Je-Min, TELLIDES, George

“…Ligands activating the transcription factor peroxisome proliferator-activated receptor-γ (PPARγ) have antiinflammatory effects. Vascular rejection induced by…”
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Interferon-γ elicits arteriosclerosis in the absence of leukocytes by Tellides, George, Tereb, Denis A, Kirkiles-Smith, Nancy C, Kim, Richard W, Wilson, Jean H, Schechner, Jeffrey S, Lorber, Marc I, Pober, Jordan S

“…Atherosclerosis and post-transplant graft arteriosclerosis are both characterized by expansion of the arterial intima as a result of the infiltration of…”
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In vivo Formation of Complex Microvessels Lined by Human Endothelial Cells in an Immunodeficient Mouse by Schechner, Jeffrey S., Nath, Anjali K., Zheng, Lian, Kluger, Martin S., Christopher C. W. Hughes, Sierra-Honigmann, M. Rocio, Lorber, Marc I., Tellides, George, Kashgarian, Michael, Alfred L. M. Bothwell, Pober, Jordan S.

“…We have identified conditions for forming cultured human umbillical vein endothelial cells (HUVEC) into tubes within a three-dimensional gel that on…”
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High-volume kidney transplantation in a developing economy by Lorber, Marc I

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Renal Allograft Failure Predictors After PAK Transplantation: Results From the New England Collaborative Association of Pancreas Programs by PAVLAKIS, Martha, KHWAJA, Khalid, MANDELBROT, Didier, HONGYING TANG, WHITING, James W, LORBER, Marc I, GAUTAM, Amitabh, JOHNSON, Scott R, UKNIS, Marc E

“…The reasons for kidney allograft failure subsequent to pancreas after kidney (PAK) are multifactorial; therefore, we examined these factors to identify a…”
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A Multicenter Pilot Study of Early (4‐Day) Steroid Cessation in Renal Transplant Recipients Under Simulect, Tacrolimus and Sirolimus by Woodle, E. Steve, Vincenti, Flavio, Lorber, Marc I., Gritsch, H. Albin, Hricik, Donald, Washburn, Kenneth, Matas, Arthur J., Gallichio, Michael, Neylan, John

“…This study presents the first prospective multicenter study assessing sirolimus‐based immunosuppression with early (4‐day) corticosteroid withdrawal (CSWD) in…”
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Pig but not Human Interferon-γ Initiates Human Cell-Mediated Rejection of Pig Tissue in vivo by Sultan, Parvez, Murray, Allan G., McNiff, Jennifer M., Lorber, Marc I., Askenase, Philip W., Alfred L. M. Bothwell, Pober, Jordan S.

“…Split-thickness pig skin was transplanted on severe combined immunodeficient mice so that pig dermal microvessels spontaneously inosculated with mouse…”
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Development of a Humanized Mouse Model to Study the Role of Macrophages in Allograft Injury by KIRKILES-SMITH, Nancy C, HARDING, Martha J, POBER, Jordan S, SHEPHERD, Benjamin R, FADER, Stacey A, TAI YI, YINONG WANG, MCNIFF, Jennifer M, SNYDER, Edward L, LO RBER, Marc I, TEIIIDES, George

“…Nearly half of all infiltrating leukocytes in rejecting human allografts are macrophages, yet, in comparison with T cells, much less is known about the…”
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A randomized trial comparing losartan with amlodipine as initial therapy for hypertension in the early post-transplant period by Formica, Richard N., Friedman, Amy L., Lorber, Marc I., Smith, J. Douglas, Eisen, Tom, Bia, Margaret J.

“…Background. Blockade of the renin–angiotensin–aldosterone system in the early post-transplant period remains controversial. Angiotensin II-receptor blockers…”
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Amelioration of Human Allograft Arterial Injury by Atorvastatin or Simvastatin Correlates With Reduction of Interferon-γ Production by Infiltrating T Cells by TAI YI, RAO, Deepak A, TANG, Paul C. Y, YINONG WANG, CUCHARA, Lisa A, BOTHWELL, Alfred L. M, COLANGELO, Christopher M, TELLIDES, George, POBER, Jordan S, LORBER, Marc I

“…Graft arteriosclerosis (GA) is an important factor limiting long-term outcomes after organ transplantation. We have used a chimeric humanized mouse system to…”
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Interferon‐γ plays a nonredundant role in mediating T‐cell‐ dependent outward vascular remodeling of allogeneic human coronary arteries by Wang, Yinong, Burns, William R., Tang, Paul C. Y., Yi, Tai, Schechner, Jeffrey S., Zerwes, Hans‐Guenter, Sessa, William C., Lorber, Marc I., Pober, Jordan S., Tellides, George

“…Vascular remodeling (change in vessel diameter) rather than intimal hyperplasia is the most important predictor of luminal loss in immune‐mediated arterial…”
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Prospective Observational Study of Sirolimus as Primary Immunosuppression After Renal Transplantation by PESCOVITZ, Mark D, NEZAKATGOO, Nosratollah, LORBER, Marc I, NASHAN, Bjorn, TEDESCO-SILVA, Helio, KASISKE, Bertram L, JUAREZ DE LA CRUZ, Federico J, RUSS, Graeme, CAMPISTOL, Joseph, KEOWN, Paul A

“…BACKGROUND.: Sirolimus (SRL) is an important component of clinical immunosuppression in renal transplantation, but few international studies have examined how…”
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What’s new in general surgery: transplantation by Lorber, Marc I

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