Search Results - "LOPRESTI, Brian J"

Molecular imaging of microglia/macrophages in the brain by Venneti, Sriram, Lopresti, Brian J., Wiley, Clayton A.

“…Neuroinflammation perpetuates neuronal damage in many neurological disorders. Activation of resident microglia and infiltration of monocytes/macrophages…”
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The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging by Venneti, Sriram, Lopresti, Brian J, Wiley, Clayton A

“…Microglia constitute the primary resident immune surveillance cell in the brain and are thought to play a significant role in the pathogenesis of several…”
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Validation of amyloid PET positivity thresholds in centiloids: a multisite PET study approach by Royse, Sarah K, Minhas, Davneet S, Lopresti, Brian J, Murphy, Alice, Ward, Tyler, Koeppe, Robert A, Bullich, Santiago, DeSanti, Susan, Jagust, William J, Landau, Susan M

“…Inconsistent positivity thresholds, image analysis pipelines, and quantitative outcomes are key challenges of multisite studies using more than one β-amyloid…”
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Effects of soy isoflavones on cognitive function: a systematic review and meta-analysis of randomized controlled trials by Cui, Chendi, Birru, Rahel L, Snitz, Beth E, Ihara, Masafumi, Kakuta, Chikage, Lopresti, Brian J, Aizenstein, Howard J, Lopez, Oscar L, Mathis, Chester A, Miyamoto, Yoshihiro, Kuller, Lewis H, Sekikawa, Akira

“…Abstract Context The results of preclinical and observational studies support the beneficial effect of soy isoflavones on cognition. Objective This review…”
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Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease by Ikonomovic, Milos D., Klunk, William E., Abrahamson, Eric E., Mathis, Chester A., Price, Julie C., Tsopelas, Nicholas D., Lopresti, Brian J., Ziolko, Scott, Bi, Wenzhu, Paljug, William R., Debnath, Manik L., Hope, Caroline E., Isanski, Barbara A., Hamilton, Ronald L., DeKosky, Steven T.

“…The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PiB) binds with high affinity to β-pleated sheet aggregates of the amyloid-β (Aβ)…”
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Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens by LING LIN, Philana, COLEMAN, Teresa, KLEIN, Edwin, BARRY, Clifton E, FLYNN, Joanne L, CARNEY, Jonathan P. J, LOPRESTI, Brian J, TOMKO, Jaime, FILLMORE, Dan, DARTOIS, Veronique, SCANGA, Charles, FRYE, L. James, JANSSEN, Christopher

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Development of Positron Emission Tomography β-Amyloid Plaque Imaging Agents by Mathis, Chester A., PhD, Mason, N. Scott, PhD, Lopresti, Brian J., BS, Klunk, William E., MD, PhD

“…For 100 years, β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) have been recognized as the neuropathological hallmarks of Alzheimer's disease (AD),…”
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Influence of apolipoprotein-E genotype on brain amyloid load and longitudinal trajectories by Lopresti, Brian J., Campbell, Elizabeth M., Yu, Zheming, Anderson, Stewart J., Cohen, Ann D., Minhas, Davneet S., Snitz, Beth E., Royse, Sarah K., Becker, Carl R., Aizenstein, Howard J., Mathis, Chester A., Lopez, Oscar L., Klunk, William E., Tudorascu, Dana L.

“…To characterize the influence of apolipoprotein-E (APOE) genotype on cerebral Aβ load and longitudinal Aβ trajectories, [11C]Pittsburgh compound-B (PiB)…”
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Relative 11C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session 15O-Water and 11C-PiB PET by Chen, Yin J, Rosario, Bedda L, Mowrey, Wenzhu, Laymon, Charles M, Lu, Xueling, Lopez, Oscar L, Klunk, William E, Lopresti, Brian J, Mathis, Chester A, Price, Julie C

“…The primary goal of this study was to assess the suitability of (11)C-Pittsburgh compound B ((11)C-PiB) blood-brain barrier delivery (K1) and relative delivery…”
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First-in-Humans Evaluation of 18F-SMBT-1, a Novel 18F-Labeled Monoamine Oxidase-B PET Tracer for Imaging Reactive Astrogliosis by Villemagne, Victor L, Harada, Ryuichi, Doré, Vincent, Furumoto, Shozo, Mulligan, Rachel, Kudo, Yukitsuka, Burnham, Samantha, Krishnadas, Natasha, Bozinovski, Svetlana, Huang, Kun, Lopresti, Brian J, Yanai, Kazuhiko, Rowe, Christopher C, Okamura, Nobuyuki

“…Reactive gliosis, characterized by reactive astrocytes and activated microglia, contributes greatly to neurodegeneration throughout the course of Alzheimer…”
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Association between lower body temperature and increased tau pathology in cognitively normal older adults by Blessing, Esther M., Parekh, Ankit, Betensky, Rebecca A., Babb, James, Saba, Natalie, Debure, Ludovic, Varga, Andrew W., Ayappa, Indu, Rapoport, David M., Butler, Tracy A., de Leon, Mony J., Wisniewski, Thomas, Lopresti, Brian J., Osorio, Ricardo S.

“…Preclinical studies suggest body temperature (Tb) and consequently brain temperature has the potential to bidirectionally interact with tau pathology in…”
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Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B by Price, Julie C, Klunk, William E, Lopresti, Brian J, Lu, Xueling, Hoge, Jessica A, Ziolko, Scott K, Holt, Daniel P, Meltzer, Carolyn C, DeKosky, Steven T, Mathis, Chester A

“…A valid quantitative imaging method for the measurement of amyloid deposition in humans could improve Alzheimer's disease (AD) diagnosis and antiamyloid…”
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Radiosynthesis, In Vitro and In Vivo Evaluation of [18F]CBD-2115 as a First-in-Class Radiotracer for Imaging 4R-Tauopathies by Lindberg, Anton, Knight, Ashley C, Sohn, Daniel, Rakos, Laszlo, Tong, Junchao, Radelet, April, Mason, N. Scott, Stehouwer, Jeffrey S, Lopresti, Brian J, Klunk, William E, Sandell, Johan, Sandberg, Alexander, Hammarström, Per, Svensson, Samuel, Mathis, Chester A, Vasdev, Neil

“…CBD-2115 was selected from a library of 148 compounds based on a pyridinyl-indole scaffold as a first-in-class 4R-tau radiotracer. In vitro binding assays…”
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PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET by Venneti, Sriram, Lopresti, Brian J, Wang, Guoji, Hamilton, Ronald L, Mathis, Chester A, Klunk, William E, Apte, Udayan M, Wiley, Clayton A

“…Abstract Activated microglia may promote neurodegeneration in Alzheimer's disease (AD) and may also help in amyloid clearance in immunization therapies. In…”
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Low thalamic activity during a digit-symbol substitution task is associated with symptoms of subjective cognitive decline by Mizuno, Akiko, Karim, Helmet Talib, Ly, Maria J, Lopresti, Brian J, Cohen, Ann D, Ali, Areej A, Mathis, Chester A, Klunk, William E, Aizenstein, Howard J, Snitz, Beth E

“…Subjective cognitive decline (SCD) may represent the earliest preclinical stage of Alzheimer's Disease (AD) for some older adults. However, the underlying…”
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Ligand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies by Lindberg, Anton, Murrell, Emily, Tong, Junchao, Mason, N. Scott, Sohn, Daniel, Sandell, Johan, Ström, Peter, Stehouwer, Jeffrey S., Lopresti, Brian J., Viklund, Jenny, Svensson, Samuel, Mathis, Chester A., Vasdev, Neil

“…Positron emission tomography (PET) imaging of tau aggregation in Alzheimer’s disease (AD) is helping to map and quantify the in vivo progression of AD…”
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Cell therapy for ARDS: efficacy of endobronchial versus intravenous administration and biodistribution of MAPCs in a large animal model by Cardenes, Nayra, Aranda-Valderrama, Paola, Carney, Jonathan P, Sellares Torres, Jacobo, Alvarez, Diana, Kocydirim, Ergin, Wolfram Smith, Julie A, Ting, Antony E, Lagazzi, Luigi, Yu, Zheming, Mason, Scott, Santos, Ernesto, Lopresti, Brian J, Rojas, Mauricio

“…IntroductionBone marrow-derived multipotent adult progenitor cells (MAPCs) are adult allogeneic adherent stem cells currently investigated clinically for use…”
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Associations between NIH Toolbox Cognition Battery and in vivo brain amyloid and tau pathology in non‐demented older adults by Snitz, Beth E., Tudorascu, Dana L., Yu, Zheming, Campbell, Elizabeth, Lopresti, Brian J., Laymon, Charles M., Minhas, Davneet S., Nadkarni, Neelesh K., Aizenstein, Howard J., Klunk, William E., Weintraub, Sandra, Gershon, Richard C., Cohen, Ann D.

“…Introduction The National Institutes of Health (NIH) Toolbox Cognition Battery (NIHTB‐CB) was developed to be a common assessment metric across a broad array…”
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Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease by Ziolko, Scott K., Weissfeld, Lisa A., Klunk, William E., Mathis, Chester A., Hoge, Jessica A., Lopresti, Brian J., DeKosky, Steven T., Price, Julie C.

“…Deposition of amyloid plaques is believed to be a central event in the development of Alzheimer's disease (AD). The present study was undertaken to evaluate…”
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Impact of amyloid imaging on drug development in Alzheimer's disease by Mathis, Chester A, Lopresti, Brian J, Klunk, William E

“…Abstract Imaging agents capable of assessing amyloid-beta (Aβ) content in vivo in the brains of Alzheimer's disease (AD) subjects likely will be important as…”
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