Search Results - "LOPEZ‐MUÑOZ, FRANCISCO JAVIER"
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Sigma‐1 receptor antagonist (BD‐1063) potentiates the antinociceptive effect of quercetin in neuropathic pain induced by chronic constriction injury
Published in Drug development research (01-04-2021)“…Neuropathic pain is characterized by the presence of hyperalgesia and allodynia. Pharmacological treatments include the use of antiepileptics such as…”
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Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury
Published in Basic & clinical pharmacology & toxicology (01-12-2017)“…Neuropathic pain has proven to be a difficult condition to treat, so investigational therapy has been sought that may prove useful, such as the use of sigma‐1…”
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Affinin and hexahydroaffinin: Chemistry and toxicological profile
Published in Drug development research (01-12-2020)“…The present work aimed to determine the safety parameters of two new alkamides, affinin and hexahydroaffinin, with antinociceptive activity. To predict the…”
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The Antinociceptive Effects of Tramadol and/or Gabapentin on Rat Neuropathic Pain Induced by a Chronic Constriction Injury
Published in Drug development research (01-08-2016)“…Preclinical Research The current work evaluates the interaction between two commonly used drugs, tramadol (Tra) and gabapentin (Gbp). Dose‐response curves…”
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Pharmacokinetics and pharmacodynamics of metamizol in co‐administration with morphine under acute and chronic treatments in arthritic rats
Published in Journal of pharmacy and pharmacology (01-06-2017)“…Objective To investigate the relationship between metamizol pharmacokinetics and the antinociceptive effect produced after subcutaneous administration of…”
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Limonene from Agastache mexicana essential oil produces antinociceptive effects, gastrointestinal protection and improves experimental ulcerative colitis
Published in Journal of ethnopharmacology (15-11-2021)“…Agastache mexicana is a popular plant of great demand in folk medicine, essentially due to its calming properties and for alleviating arthritic, muscular and…”
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Antinociceptive Interactions Between Meloxicam and Gabapentin in Neuropathic Pain Depend on the Ratio used in Combination in Rats
Published in Drug development research (01-05-2016)“…Preclinical Research Neuropathic pain is particularly difficult to treat because of its diverse etiologies and underlying pathophysiological mechanisms. Drug…”
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The Effect of Gabapentin and Tramadol in Cancer Pain Induced by Glioma Cell in Rat Femur
Published in Drug development research (01-08-2017)“…ABSTRACT Preclinical Research The presence of pain as part of the cancer process is variable. Glioblastoma multiform (GBM) can produce bone metastasis, a…”
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Nociceptive Alteration by High Sucrose Diet in Hypoestrogenic Wistar Rats
Published in Drug development research (01-08-2016)“…Preclinical Research Obesity is a risk factor associated with alterations in pain perception. The aim of this study was to analyse a time‐course of nociceptive…”
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Antinociceptive Effect of Racemic Flurbiprofen and Caffeine Co-Administration in an Arthritic Gout-Type Pain in Rats
Published in Drug development research (01-06-2016)“…Preclinical Research Drug combinations are routinely used in the treatment of pain. In drug associations, adjuvants such as caffeine, are employed with…”
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Antihyperalgesic activity of a novel synthesized analogue of lidocaine in diabetic rats
Published in Journal of pharmacy and pharmacology (01-05-2013)“…Objectives The purpose of this study was to assess the antinociceptive and antihyperalgesic effects of a lidocaine analogue…”
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Antinociceptive Activity of Metamizol Metabolites in a Rat Model of Arthritic Pain
Published in Drug development research (01-08-2013)“…Preclinical Research The aim of the present study was to evaluate the antinociceptive activity of the main metamizol (MET) metabolites, 4‐methylaminoantipyrine…”
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Cysticidal activity of praziquantel-mebendazole combination: In vitro and in vivo studies
Published in Acta tropica (01-02-2020)“…•Praziquantel (PZQ) displays a sinergistic interaction with mebendazole (MBZ).•The combination exibited the cystidal effect in a shorter time than single…”
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Synergistic antinociceptive interaction between palmitoylethanolamide and tramadol in the mouse formalin test
Published in European journal of pharmacology (15-10-2015)“…Pharmacological synergism has been used to obtain a higher efficacy using drug concentrations at which side effects are minimal. In this study, the…”
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Antinociceptive effects of a new sigma-1 receptor antagonist (N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy)acetamide) in two types of nociception
Published in European journal of pharmacology (15-01-2016)“…Pain has become an active clinical challenge due its etiological heterogeneity, symptoms and mechanisms of action. In the search for new pharmacological…”
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Anti-nociceptive synergism of morphine and gabapentin in neuropathic pain induced by chronic constriction injury
Published in Pharmacology, biochemistry and behavior (01-05-2009)“…In order to detect an anti-nociceptive interaction between morphine and gabapentin, the anti-allodynic and anti-hyperalgesic effects of these drugs,…”
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17
High-performance liquid chromatographic assay for metamizol metabolites in rat plasma: Application to pharmacokinetic studies
Published in Journal of pharmaceutical and biomedical analysis (01-12-2012)“…In order to evaluate the pharmacokinetics of metamizol in the presence of morphine in arthritic rats, after subcutaneous administration of the drugs, an easy,…”
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18
Effect of tramadol on metamizol pharmacokinetics and pharmacodynamics after single and repeated administrations in arthritic rats
Published in Saudi pharmaceutical journal (01-11-2016)“…Combined administration of certain doses of opioid compounds with a non-steroidal anti-inflammatory drug can produce additive or supra-additive effects while…”
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Effect of metamizol on morphine pharmacokinetics and pharmacodynamics after acute and subchronic administration in arthritic rats
Published in European journal of pharmacology (25-10-2010)“…The aim of the present study was to investigate whether metamizol alters the pharmacokinetics of morphine and to determine the relationship between morphine…”
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HPLC Method with Solid-Phase Extraction for Determination of (R)- and (S)-Ketoprofen in Plasma without Caffeine Interference: Application to Pharmacokinetic Studies in Rats
Published in Journal of chromatographic science (01-11-2014)“…A fast and reproducible high-performance liquid chromatography method has been developed for the determination of (R)- and (S)-ketoprofen. Ketoprofen…”
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