Search Results - "LOPEZ, Bernard S"

Is non-homologous end-joining really an inherently error-prone process? by Bétermier, Mireille, Bertrand, Pascale, Lopez, Bernard S

“…DNA double-strand breaks (DSBs) are harmful lesions leading to genomic instability or diversity. Non-homologous end-joining (NHEJ) is a prominent DSB repair…”
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Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response by Ragu, Sandrine, Matos-Rodrigues, Gabriel, Lopez, Bernard S

“…Complete and accurate DNA replication is essential to genome stability maintenance during cellular division. However, cells are routinely challenged by…”
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Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells by Rass, Emilie, Gautier, Jean, Bertrand, Pascale, Grabarz, Anastazja, Plo, Isabelle, Lopez, Bernard S

“…The MRN complex is known to play a role in the cellular response to DNA double-strand breaks in higher eukaryotes, particularly in damage signaling and…”
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Is homologous recombination really an error-free process? by Guirouilh-Barbat, Josée, Lambert, Sarah, Bertrand, Pascale, Lopez, Bernard S

“…Homologous recombination (HR) is an evolutionarily conserved process that plays a pivotal role in the equilibrium between genetic stability and diversity. HR…”
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53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks by Guirouilh-Barbat, Josée, Gelot, Camille, Xie, Anyong, Dardillac, Elodie, Scully, Ralph, Lopez, Bernard S

“…DNA double-strand breaks (DSB) are very harmful lesions that can generate genome rearrangements. In this study, we used intrachromosomal reporters to compare…”
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Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage by Técher, Hervé, Koundrioukoff, Stéphane, Carignon, Sandra, Wilhelm, Therese, Millot, Gaël A., Lopez, Bernard S., Brison, Olivier, Debatisse, Michelle

“…Mammalian cells deficient in ATR or Chk1 display moderate replication fork slowing and increased initiation density, but the underlying mechanisms have…”
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Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress by Wilhelm, Therese, Ragu, Sandrine, Magdalou, Indiana, Machon, Christelle, Dardillac, Elodie, Técher, Hervé, Guitton, Jérôme, Debatisse, Michelle, Lopez, Bernard S

“…Replications forks are routinely hindered by different endogenous stresses. Because homologous recombination plays a pivotal role in the reactivation of…”
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Genomic rearrangements induced by unscheduled DNA double strand breaks in somatic mammalian cells by So, Ayeong, Le Guen, Tangui, Lopez, Bernard S., Guirouilh‐Barbat, Josée

“…DNA double‐strand breaks (DSBs) are highly toxic lesions that can lead to profound genome rearrangements and/or cell death. They routinely occur in genomes due…”
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Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells by Whilhelm, Therese, Magdalou, Indiana, Barascu, Aurélia, Técher, Hervé, Debatisse, Michelle, Lopez, Bernard S.

“…Homologous recombination deficient (HR ⁻) mammalian cells spontaneously display reduced replication fork (RF) movement and mitotic extra centrosomes. We show…”
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Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1 by Barton, Olivia, Naumann, Steffen C, Diemer-Biehs, Ronja, Künzel, Julia, Steinlage, Monika, Conrad, Sandro, Makharashvili, Nodar, Wang, Jiadong, Feng, Lin, Lopez, Bernard S, Paull, Tanya T, Chen, Junjie, Jeggo, Penny A, Löbrich, Markus

“…DNA double-strand breaks (DSBs) are repaired by nonhomologous end joining (NHEJ) or homologous recombination (HR). The C terminal binding protein-interacting…”
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PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways by Beck, Carole, Boehler, Christian, Guirouilh Barbat, Josée, Bonnet, Marie-Elise, Illuzzi, Giuditta, Ronde, Philippe, Gauthier, Laurent R., Magroun, Najat, Rajendran, Anbazhagan, Lopez, Bernard S., Scully, Ralph, Boussin, François D., Schreiber, Valérie, Dantzer, Françoise

“…The repair of toxic double-strand breaks (DSB) is critical for the maintenance of genome integrity. The major mechanisms that cope with DSB are: homologous…”
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A Role for BLM in Double-Strand Break Repair Pathway Choice: Prevention of CtIP/Mre11-Mediated Alternative Nonhomologous End-Joining by Grabarz, Anastazja, Guirouilh-Barbat, Josée, Barascu, Aurélia, Pennarun, Gaëlle, Genet, Diane, Rass, Emilie, Germann, Susanne M., Bertrand, Pascale, Hickson, Ian D., Lopez, Bernard S.

“…The choice of the appropriate double-strand break (DSB) repair pathway is essential for the maintenance of genomic stability. Here, we show that the Bloom…”
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Cellular uptake pathways of sepiolite nanofibers and DNA transfection improvement by Castro-Smirnov, Fidel Antonio, Ayache, Jeanne, Bertrand, Jean-Rémi, Dardillac, Elodie, Le Cam, Eric, Piétrement, Olivier, Aranda, Pilar, Ruiz-Hitzky, Eduardo, Lopez, Bernard S.

“…Sepiolite is a nanofibrous natural silicate that can be used as a nanocarrier because it can be naturally internalized into mammalian cells, due to its…”
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AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51 by Plo, Isabelle, Laulier, Corentin, Gauthier, Laurent, Lebrun, Fabienne, Calvo, Fabien, Lopez, Bernard S

“…AKT1 is frequently up-regulated in sporadic breast cancer, whereas BRCA1 is frequently mutated in familial breast cancer. Because BRCA1 is involved in…”
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Homologous recombination, cancer and the ‘RAD51 paradox’ by Matos-Rodrigues, Gabriel, Guirouilh-Barbat, Josée, Martini, Emmanuelle, Lopez, Bernard S

“…Abstract Genetic instability is a hallmark of cancer cells. Homologous recombination (HR) plays key roles in genome stability and variability due to its roles…”
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Noncanonical Roles of RAD51 by Thomas, Mélissa, Dubacq, Caroline, Rabut, Elise, Lopez, Bernard S, Guirouilh-Barbat, Josée

“…Homologous recombination (HR), an evolutionary conserved pathway, plays a paramount role(s) in genome plasticity. The pivotal HR step is the strand…”
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Defects in XRCC4 and KU80 Differentially Affect the Joining of Distal Nonhomologous Ends by Guirouilh-Barbat, Josée, Rass, Emilie, Plo, Isabelle, Bertrand, Pascale, Lopez, Bernard S.

“…XRCC4-null mice have a more severe phenotype than KU80-null mice. Here, we address whether this difference in phenotype is connected to nonhomologous…”
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Impact of the KU80 Pathway on NHEJ-Induced Genome Rearrangements in Mammalian Cells by Guirouilh-Barbat, Josée, Huck, Sylvie, Bertrand, Pascale, Pirzio, Livia, Desmaze, Chantal, Sabatier, Laure, Lopez, Bernard S.

“…Using a substrate measuring deletion or inversion of an I-SceI-excised fragment and both accurate and inaccurate rejoining, we determined the impact of…”
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Correction: ATRIP protects progenitor cells against DNA damage in vivo by Matos-Rodrigues, Gabriel E., Grigaravicius, Paulius, Lopez, Bernard S., Hofmann, Thomas G., Frappart, Pierre-Olivier, Martins, Rodrigo A. P.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41419-020-03227-w…”
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homologous recombination defect affects replication-fork progression in mammalian cells by Daboussi, Fayza, Courbet, Sylvain, Benhamou, Simone, Kannouche, Patricia, Zdzienicka, Malgorzata Z, Debatisse, Michelle, Lopez, Bernard S

“…Faithful genome transmission requires a network of pathways coordinating DNA replication to DNA repair and recombination. Here, we used molecular combing to…”
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