Search Results - "LOPES, José Manuel"

The mTOR signalling pathway in human cancer by Pópulo, Helena, Lopes, José Manuel, Soares, Paula

“…The conserved serine/threonine kinase mTOR (the mammalian target of rapamycin), a downstream effector of the PI3K/AKT pathway, forms two distinct multiprotein…”
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Pain as the fifth vital sign-A comparison between public and private healthcare systems by Pozza, Daniel Humberto, Azevedo, Luís Filipe, Castro Lopes, José Manuel

“…The assessment of pain as the fifth vital sign (P5VS) is of paramount importance since it leads to the management of undertreated pain, consequently reducing…”
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Telomere Maintenance Mechanisms in Cancer by Gaspar, Tiago Bordeira, Sá, Ana, Lopes, José Manuel, Sobrinho-Simões, Manuel, Soares, Paula, Vinagre, João

“…Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere shortening, an inevitable process due to successive cell divisions. In most…”
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Pharmacogenomic biomarkers as source of evidence of the effectiveness and safety of antidepressant therapy by Correia, Catarina, Alcobia, Luciano, Lopes, Manuel José, Advinha, Ana Margarida

“…Objective The main goal of this work was to identify, describe, characterize, and classify the scientific evidence regarding the use of pharmacogenomic…”
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Pharmacovigilance teaching and learning: a mixed cross-sectional analysis of the Portuguese public higher education system by Perdigão, Margarida, Afonso, Anabela, de Oliveira-Martins, Sofia, Lopes, Manuel José, Advinha, Ana Margarida

“…Pharmacovigilance stands out for its importance in obtaining existing knowledge about medicine and patient safety and should be recognized as a continuous line…”
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Key factors of the functional ability of older people to self-manage medications by Advinha, Ana Margarida, Nunes, Carla, de Barros, Carla Teixeira, Lopes, Manuel José, de Oliveira-Martins, Sofia

“…Daily medication use can be affected by the gradual loss of functional ability. Thus, elderly patients are at risk for nonadherence due to functional decline,…”
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Depression in older adults during the COVID-19 pandemic: a systematic review protocol by Silva, Celso, Fonseca, César, Ferreira, Rogério, Pinho, Lara, Schneider, Brooke C, Weidner, Anna, Morgado, Bruno, Lopes, Manuel José

“…IntroductionDepression is a common mental disorder and is a major cause of years lived with disability. The COVID-19 pandemic has caused an increase in the…”
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Medication regimen complexity in institutionalized elderly people in an aging society by Advinha, Ana Margarida, de Oliveira-Martins, Sofia, Mateus, Vanessa, Pajote, Sara Grou, Lopes, Manuel José

“…Background Complex medication regimens may adversely affect compliance and treatment outcomes. Complexity can be assessed with the medication regimen…”
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mTOR Pathway Overactivation in BRAF Mutated Papillary Thyroid Carcinoma by Faustino, Alexandra, Couto, Joana P, Pópulo, Helena, Rocha, Ana Sofia, Pardal, Fernando, Cameselle-Teijeiro, José Manuel, Lopes, José Manuel, Sobrinho-Simões, Manuel, Soares, Paula

“…Context: There are several genetic and molecular evidences suggesting dysregulation of the mammalian target of rapamycin (mTOR) pathway in thyroid neoplasia…”
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The Elderly Nursing Core Set and the cognition of Portuguese older adults: a cross-sectional study by Fonseca, César, de Pinho, Lara Guedes, Lopes, Manuel José, Marques, Maria do Céu, Garcia-Alonso, José

“…The aging population and its associated health needs require specific nursing care. The aim of this study was to draw an epidemiological profile of Portuguese…”
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Pathology, therapy and prognosis of papillary renal carcinoma by Fernandes, Diana Silva, Lopes, José Manuel

“…Papillary renal cell carcinoma (pRCC) accounts for approximately 10% of renal parenchymal tumors. There are two pRCC subtypes reported in several studies, but…”
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Family Self-Care in Chronic Disease Management: An Evolving Care Pattern? by Mestre, Teresa Dionísio, Caldeira, Ermelinda Valente, Lopes, Manuel José

“…Self-care emerges in the family context, despite being seen as an individual determinant of health. The family, understood as a system and social unit,…”
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Association between Functional EGF+61 Polymorphism and Glioma Risk by MARQUES COSTA, Bruno, FERREIRA, Paulo, REIS, Rui Manuel, COSTA, Sandra, CANEDO, Paulo, OLIVEIRA, Pedro, SILVA, Ana, PARDAL, Fernando, SURIANO, Gianpaolo, MACHADO, José Carlos, LOPES, José Manuel

“…Purpose: Epidermal growth factor (EGF) plays a critical role in cancer. A polymorphism in the EGF gene ( EGF +61) may influence its expression and contribute…”
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SDHD promoter mutations are rare events in cutaneous melanomas but SDHD protein expression is downregulated in advanced cutaneous melanoma by Pópulo, Helena, Batista, Rui, Sampaio, Cristina, Pardal, Joana, Lopes, José Manuel, Soares, Paula

“…SDHD promoter mutations were reported in 4-10% of cutaneous melanomas. The advanced clinico-pathological and patient survival association with SDHD mutation…”
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Periocular Sebaceous Carcinoma With Apocrine Differentiation: A Case Report and Review of the Literature by Pinheiro, Jorge Adriano Ferreira, Lopes, José Manuel Pedrosa Baptista

“…A 61-year-old man presented with a dome-shaped tumor in the right eyelid. Histology revealed a cutaneous neoplasm with lobular growth pattern. It was composed…”
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Head and neck cutaneous basal cell carcinoma: what should the otorhinolaryngology head and neck surgeon care about? by Castanheira, António, Boaventura, Paula, Pais Clemente, Manuel, Soares, Paula, Mota, Alberto, Lopes, José Manuel

“…Cutaneous basal cell carcinoma (cBCC) is the most common malignancy diagnosed in the human population. cBCC presents an increasing incidence which, in the near…”
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Molecular alterations and expression of succinate dehydrogenase complex in wild-type KIT/PDGFRA/BRAF gastrointestinal stromal tumors by Celestino, Ricardo, Lima, Jorge, Faustino, Alexandra, Vinagre, João, Máximo, Valdemar, Gouveia, António, Soares, Paula, Lopes, José Manuel

“…Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, disclosing somatic KIT, PDGFRA and BRAF…”
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AIRP best cases in radiologic-pathologic correlation: gastroblastoma: a rare biphasic gastric tumor by Fernandes, Teresa, Silva, Roberto, Devesa, Vítor, Lopes, José Manuel, Carneiro, Fátima, Viamonte, Bárbara

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Nursing students’ perceptions on clinical learning environment and mental health: a multicenter study by Karaduman, Gul Sahin, Bakir, Gizem Kubat, Sim-Sim, Maria Margarida Santana Fialho, Basak, Tulay, Goktas, Sonay, Skarbalienė, Aelita, Brasaitė-Abromė, Indrė, Lopes, Manuel José

“…Abstract Objective: this study aimed at evaluating the perceptions of Nursing students from public universities in three European Union countries on mental…”
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Histological Subtypes and Clinical Behavior Evaluation of Salivary Gland Tumors by Pinheiro, Jorge, Sá Fernandes, Margarida, Pereira, Ana Rodrigues, Lopes, José Manuel

“…Salivary gland tumors include a wide spectrum of histological subtypes and clinical behavior, which we aim to evaluate. We performed a retrospective study of…”
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