Search Results - "LOPER, A. E"

Identification of oxidative degradates of the thrombin inhibitor, 3-(2-phenethylamino)-6-methyl-1-(2-amino-6-methyl-5-methylenecarboxamidomethylpyridinyl)pyrazinone, using liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry by Wu, Yunhui, Chen, Xin, Gier, Lynn, Almarsson, Örn, Ostovic, Drazen, Loper, Alice E.

“…Liquid chromatography/mass spectrometry was used to identify reaction products from a solution of…”
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Regiospecific intestinal absorption of the HIV protease inhibitor L-735,524 in beagle dogs by KWEI, G. Y, NOVAK, L. B, HETTRICK, L. A, REISS, E. R, OSTOVIC, D, LOPER, A. E, LUI, C. Y, HIGGINS, R. J, I-WU CHEN, LIN, J. H

“…To evaluate regional intestinal absorption and the feasibility of sustained release dosage form development for an HIV protease inhibitor, L-735,524, L-735,524…”
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Antiparkinsonian efficacy of a novel transdermal delivery system for (+)-PHNO in MPTP-treated squirrel monkeys by RUPNIAK, N. M. J, TYE, S. J, JENNINGS, C. A, LOPER, A. E, BONDI, J. V, HICHENS, M, HAND, E, IVERSEN, S. D, STAHL, S. M

“…We examined the ability of the antiparkinsonian agent (+)-4-propyl-9-hydroxynaphthoxazine (PHNO) to enter the systemic circulation in therapeutic…”
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The antiparkinsonian actions and pharmacokinetics of transdermal (+)-4-propyl-9-hydroxynaphthoxazine (+PHNO): preliminary results by Coleman, R J, Lange, K W, Quinn, N P, Loper, A E, Bondi, J V, Hichens, M, Stahl, S M, Marsden, C D

“…(+)-4-Propyl-9-hydroxynaphthoxazine (+PHNO) is a potent dopamine agonist that has been administered transdermally to four patients with Parkinson's disease and…”
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Therapeutic efficacy of a novel transdermal delivery system for (+)-PHNO in parkinsonian squirrel monkeys by Rupniak, N M, Tye, S J, Jennings, C A, Loper, A E, Bondi, J V, Hichens, M, Iversen, S D, Stahl, S M

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Initial evaluation of transdermal timolol: serum concentrations and beta-blockade by Vlasses, P H, Ribeiro, L G, Rotmensch, H H, Bondi, J V, Loper, A E, Hichens, M, Dunlay, M C, Ferguson, R K

“…The serum concentrations and beta-blockade after dermal application of timolol ointment were evaluated in six healthy men (21-31 years old; 74-82 kg). Two…”
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Lymphatic uptake of MK-386, a sterol 5 α-reductase inhibitor, from aqueous and lipid formulations by Kwei, Gloria Y, Novak, Linda B, Hettrick, Lisa H, Reiss, Elisabeth R, Fong, Eva K, Olah, Timothy V, Loper, Alice E

“…4,7- β-Dimethyl-4-aza-5 α-cholestan-3-one (MK-386) is a specific inhibitor of type-1 5 α-reductase, with over 10 4-fold greater solubility in lipid-type…”
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Routes of exposure: Topical and transdermal by Cukierski, Matthew J., Loper, Alice E.

“…The dermal route of administration poses a number of scientific, technical, and regulatory challenges to those charged with characterizing the safety of new…”
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Summary workshop report: biopharmaceutics classification system--implementation challenges and extension opportunities by Polli, James E, Yu, Lawrence X, Cook, Jack A, Amidon, Gordon L, Borchardt, Ronald T, Burnside, Beth A, Burton, Philip S, Chen, Mei-Ling, Conner, Dale P, Faustino, Patrick J, Hawi, Amale A, Hussain, Ajaz S, Joshi, Hemant N, Kwei, Gloria, Lee, Vincent H L, Lesko, Lawrence J, Lipper, Robert A, Loper, Alice E, Nerurkar, Shriniwas G, Polli, Joseph W, Sanvordeker, Dilip R, Taneja, Rajneesh, Uppoor, Ramana S, Vattikonda, Chandra S, Wilding, Ian, Zhang, Guohua

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Improved method for rhesus monkey or rat skin preparation and cryosectioning for topical or transdermal skin distribution studies by Fong, E K, Frank, J D, Cartwright, M E, Loper, A E

“…A method for preparing skin biopsies for cryosectioning was developed to accurately obtain samples from specific areas of the dermis, while minimizing…”
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