Search Results - "LOOSER, Renate"

Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms by Lundberg, Pontus, Karow, Axel, Nienhold, Ronny, Looser, Renate, Hao-Shen, Hui, Nissen, Ina, Girsberger, Sabine, Lehmann, Thomas, Passweg, Jakob, Stern, Martin, Beisel, Christian, Kralovics, Robert, Skoda, Radek C.

“…Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by aberrant hematopoietic proliferation and an increased tendency toward…”
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Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice by Tiedt, Ralph, Hao-Shen, Hui, Sobas, Marta A., Looser, Renate, Dirnhofer, Stephan, Schwaller, Jürg, Skoda, Radek C.

“…An acquired somatic mutation in the JAK2 gene (JAK2-V617F) is present in the majority of patients with myeloproliferative disorders (MPDs). Several phenotypic…”
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Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression by Roth, Adrian, Looser, Renate, Kaufmann, Michel, Blättler, Sharon M, Rencurel, Franck, Huang, Wendong, Moore, David D, Meyer, Urs A

“…Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by xenobiotic inducers of cytochromes P450 is part of a pleiotropic response…”
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Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver by Rencurel, Franck, Foretz, Marc, Kaufmann, Michel R, Stroka, Deborah, Looser, Renate, Leclerc, Isabelle, da Silva Xavier, Gabriela, Rutter, Guy A, Viollet, Benoit, Meyer, Urs A

“…Our previous studies have suggested a role for AMP-activated protein kinase (AMPK) in the induction of CYP2B6 by phenobarbital (PB) in hepatoma-derived cells…”
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Identification of the Xenosensors Regulating Human 5-Aminolevulinate Synthase by Podvinec, Michael, Handschin, Christoph, Looser, Renate, Meyer, Urs A., Schmid, Rudi

“…Heme is an essential component of numerous hemoproteins with functions including oxygen transport, energy metabolism, and drug biotransformation. In…”
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Parallel and Independent Regulation of Interleukin-3 mRNA Turnover by Phosphatidylinositol 3-Kinase and p38 Mitogen-Activated Protein Kinase by Ming, Xiu-Fen, Stoecklin, Georg, Lu, Min, Looser, Renate, Moroni, Christoph

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Somatic mRNA Turnover Mutants Implicate Tristetraprolin in the Interleukin-3 mRNA Degradation Pathway by Stoecklin, Georg, Ming, Xiu-Fen, Looser, Renate, Moroni, Christoph

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The allele burden of JAK2 mutations remains stable over several years in patients with myeloproliferative disorders by Theocharides, Alexandre, Passweg, Jakob R, Medinger, Michael, Looser, Renate, Li, Sai, Hao-Shen, Hui, Buser, Andreas S, Gratwohl, Alois, Tichelli, Andre, Skoda, Radek C

“…1 Experimental Hematology, Department of Biomedicine, University Hospital Basel, Basel 2 Division of Hematology, University Hospital Basel, Basel 3 Division of…”
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Cholesterol and Bile Acids Regulate Xenosensor Signaling in Drug-mediated Induction of Cytochromes P450 by Handschin, Christoph, Podvinec, Michael, Amherd, Remo, Looser, Renate, Ourlin, Jean-Claude, Meyer, Urs A.

“…Cytochromes P450 (CYP) constitute the major enzymatic system for metabolism of xenobiotics. Here we demonstrate that transcriptional activation of CYPs by the…”
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LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver by Gnerre, Carmela, Schuster, Gertrud U, Roth, Adrian, Handschin, Christoph, Johansson, Lisen, Looser, Renate, Parini, Paolo, Podvinec, Michael, Robertsson, Kirsten, Gustafsson, Jan-Åke, Meyer, Urs A

“…Metabolic transformation by the superfamily of cytochromes P450 (CYPs) plays an important role in the detoxification of xenobiotics such as drugs,…”
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Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor by Handschin, C, Podvinec, M, Looser, R, Amherd, R, Meyer, U A

“…Binding of nuclear receptors to drug-responsive enhancer units mediates transcriptional activation of cytochromes P-450 (P-450) by drugs and xenobiotics. In…”
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Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms by Schaub, Franz X., Looser, Renate, Li, Sai, Hao-Shen, Hui, Lehmann, Thomas, Tichelli, Andre, Skoda, Radek C.

“…Somatic mutations in TET2 occur in patients with myeloproliferative neoplasms and other hematologic malignancies. It has been suggested that TET2 is a tumor…”
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Significance of chaperonin 10-mediated inhibition of ATP hydrolysis by chaperonin 60 by Dubaquie, Y, Looser, R, Rospert, S

“…Chaperonins are essential for the folding of proteins in bacteria, mitochondria, and chloroplasts. We have functionally characterized the yeast mitochondrial…”
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Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes by Roth, Adrian, Looser, Renate, Kaufmann, Michel, Meyer, Urs A

“…OBJECTIVESterol regulatory element binding protein 1 (SREBP-1) is a lipogenic transcription factor of the basic helix-loop-helix family. SREBP-1 binds to…”
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Engraftment Of Human Polycythemia Vera CD34+ Cells In hSIRPα-Transgenic-Human-TPO-Expressing RAG2-/-, IL2Rγ-/- Immunodeficient Mice by Müller, Rouven, Theocharides, Alexandre, Looser, Renate, Skoda, Radek C., Flavell, Richard A., Manz, Markus G.

“…Xenotransplantation of human hematopoietic malignancies into immunodeficient mice represents the most appropriate in vivo model system for human malignant…”
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Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the predisposing mutations for JAK2-V617F by Schaub, Franz X., Jäger, Roland, Looser, Renate, Hao-Shen, Hui, Hermouet, Sylvie, Girodon, François, Tichelli, Andre, Gisslinger, Heinz, Kralovics, Robert, Skoda, Radek C.

“…We developed a real-time copy number polymerase chain reaction assay for deletions on chromosome 20q (del20q), screened peripheral blood granulocytes from 664…”
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Complex subclone structure that responds differentially to therapy in a patient with essential thrombocythemia and chronic myeloid leukemia by Grisouard, Jean, Ojeda-Uribe, Mario, Looser, Renate, Hao-Shen, Hui, Lundberg, Pontus, Duek, Adrian, Jeandidier, Eric, Karow, Axel, Skoda, Radek C.

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Transition to homozygosity does not appear to provide a clonal advantage to hematopoietic progenitors carrying mutations in TET2 by Schaub, Franz X., Lehmann, Thomas, Looser, Renate, Hao-Shen, Hui, Tichelli, Andre, Skoda, Radek C.

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Clonal analysis of TET2 and JAK2 mutations suggests that TE7-2 can be a late event in the progression of myeloproliferative neoplasms by SCHAUB, Franz X, LOOSER, Renate, SAI LI, HUI, Hao-Shen, LEHMANN, Thomas, TICHELLI, Andre, SKODA, Radek C

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Interaction of mitochondrial targeting signals with acidic receptor domains along the protein import pathway: evidence for the 'acid chain' hypothesis by Komiya, T, Rospert, S, Koehler, C, Looser, R, Schatz, G, Mihara, K

“…Mitochondrial precursor proteins with basic targeting signals may be transported across the outer membrane by sequential binding to acidic receptor sites of…”
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