Search Results - "LOOS, R. J. F"

Early-life residential green spaces and traffic exposure in association with young adult body composition: a longitudinal birth cohort study of twins by Figaroa, M N S, Gielen, M, Casas, L, Loos, R J F, Derom, C, Weyers, S, Nawrot, T S, Zeegers, M P, Bijnens, E M

“…Globally, the rapid increase of obesity is reaching alarming proportions. A new approach to reduce obesity and its comorbidities involves tackling the built…”
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Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response by Langenberg, C, Pascoe, L, Mari, A, Tura, A, Laakso, M, Frayling, T. M, Barroso, I, Loos, R. J. F, Wareham, N. J, Walker, M

“…Aims/hypothesis We investigated whether variation in MTNR1B, which was recently identified as a common genetic determinant of fasting glucose levels in…”
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Genetic predisposition to obesity leads to increased risk of type 2 diabetes by Li, S, Zhao, J. H, Luan, J, Langenberg, C, Luben, R. N, Khaw, K. T, Wareham, N. J, Loos, R. J. F

“…Aims/hypothesis Obesity is a major risk factor for type 2 diabetes. Recent genome-wide association (GWA) studies have identified multiple loci robustly…”
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Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: heritabilities by Souren, N. Y, Paulussen, A. D. C, Loos, R. J. F, Gielen, M, Beunen, G, Fagard, R, Derom, C, Vlietinck, R, Zeegers, M. P

“…Aims/hypothesis We determined the genetic contribution of 18 anthropometric and metabolic risk factors of type 2 diabetes using a young healthy twin…”
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Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population by Qi, Q, Wu, Y, Li, H, Loos, R. J. F, Hu, F. B, Sun, L, Lu, L, Pan, A, Liu, C, Wu, H, Chen, L, Yu, Z, Lin, X

“…Aims/hypothesis The GCKR rs780094 and GCK rs1799884 polymorphisms have been reported to be associated with dyslipidaemia and type 2 diabetes in white…”
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Combined effects of 17 common genetic variants on type 2 diabetes risk in a Han Chinese population by Qi, Q, Li, H, Wu, Y, Liu, C, Wu, H, Yu, Z, Qi, L, Hu, F. B, Loos, R. J. F, Lin, X

“…Aims/hypothesis The recent advent of genome-wide association studies has considerably accelerated the identification of type 2 diabetes loci. We aimed to…”
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Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals by van Vliet-Ostaptchouk, J. V., den Hoed, M., Luan, J., Zhao, J. H., Ong, K. K., van der Most, P. J., Wong, A., Hardy, R., Kuh, D., van der Klauw, M. M., Bruinenberg, M., Khaw, K. T., Wolffenbuttel, B. H. R., Wareham, N. J., Snieder, H., Loos, R. J. F.

“…Aims/hypothesis Genetic pleiotropy may contribute to the clustering of obesity and metabolic conditions. We assessed whether genetic variants that are robustly…”
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GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity by Speakman, J. R., Loos, R. J. F., O’Rahilly, S., Hirschhorn, J. N., Allison, D. B.

“…Summary Muller et al. [ 1 ] have provided a strong critique of the Genome-Wide Association Studies (GWAS) of body-mass index (BMI), arguing that the GWAS…”
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FTO: the first gene contributing to common forms of human obesity by Loos, R.J.F, Bouchard, C

“…Genome-wide association, the latest gene-finding strategy, has led to the first major success in the field of obesity genetics with the discovery of FTO (fat…”
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Inherited susceptibility to non-alcoholic fatty liver disease by Loos, R. J. F, Savage, D. B

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Obesity – is it a genetic disorder? by Loos, R. J. F., Bouchard, C.

“…  Loos RJF, Bouchard C (Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA). Obesity – is it a genetic disorder? (Review)…”
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Heritability of somatotype components: a multivariate analysis by Peeters, M.W, Thomis, M.A, Loos, R.J.F, Derom, C.A, Fagard, R, Claessens, A.L, Vlietinck, R.F, Beunen, G.P

“…Objective: To study the genetic and environmental determination of variation in Heath-Carter somatotype (ST) components (endomorphy, mesomorphy and…”
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Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study by Ruchat, S.-M., Loos, R. J. F., Rankinen, T., Vohl, M.-C., Weisnagel, S. J., Després, J.-P., Bouchard, C., Pérusse, L.

“…Aims  Studies suggest that adiponectin (APM1) and its receptors 1 and 2 (AdipoR1 and AdipoR2) play an important role in the development of insulin resistance…”
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Obesity: lessons from evolution and the environment by Heitmann, B. L, Westerterp, K. R, Loos, R. J. F, Sørensen, T. I. A, O'Dea, K, McLean, P, Jensen, T. K, Eisenmann, J, Speakman, J. R, Simpson, S. J, Reed, D. R, Westerterp‐Plantenga, M. S

“…The 9th Stock Conference acknowledged the complex background of genetic, cultural, environmental and evolutionary factors of obesity. Gene–environment…”
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ADRB3 Trp64Arg variant and BMI: a meta-analysis of 44 833 individuals by Kurokawa, N, Young, E.H, Oka, Y, Satoh, H, Wareham, N.J, Sandhu, M.S, Loos, R.J.F

“…Background: The -3 adrenergic receptor gene (ADRB3) is part of the adrenergic system, which is known to play a key role in energy metabolism. The association…”
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Melanocortin-4 receptor gene and physical activity in the Québec Family Study by LOOS, R. J. F, RANKINEN, T, TREMBLAY, A, PERUSSE, L, CHAGNON, Y, BOUCHARD, C

“…Physical inactivity is a risk factor for numerous chronic diseases. Low compliance with interventions to increase activity suggests involvement of biological…”
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The prenatal gut microbiome: are we colonized with bacteria in utero? by Walker, R. W., Clemente, J. C., Peter, I., Loos, R. J. F.

“…Summary The colonization of the gut with microbes in early life is critical to the developing newborn immune system, metabolic function and potentially future…”
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Examining the causal association of fasting glucose with blood pressure in healthy children and adolescents: a Mendelian randomization study employing common genetic variants of fasting glucose by Goharian, T S, Andersen, L B, Franks, P W, Wareham, N J, Brage, S, Veidebaum, T, Ekelund, U, Lawlor, D A, Loos, R J F, Grøntved, A

“…The aim of the study was to determine whether genetically raised fasting glucose (FG) levels are associated with blood pressure (BP) in healthy children and…”
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Genes that make you fat, but keep you healthy by Loos, R. J. F., Kilpeläinen, T. O.

“…Obesity prevalence continues to rise worldwide, posing a substantial burden on people's health. However, up to 45% of obese individuals do not suffer from…”
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Genetic predisposition influences plasma lipids of participants on habitual diet, but not the response to reductions in dietary intake of saturated fatty acids by Walker, C.G, Loos, R.J.F, Olson, A.D, Frost, G.S, Griffin, B.A, Lovegrove, J.A, Sanders, T.A.B, Jebb, S.A

“…Abstract Objective SNPs identified from genome-wide association studies associate with lipid risk markers of cardiovascular disease. This study investigated…”
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