Search Results - "LONGO, D"

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan by Longo, Valter D., Panda, Satchidananda

“…Most animals alternate periods of feeding with periods of fasting often coinciding with sleep. Upon >24 hr of fasting, humans, rodents, and other mammals enter…”
Get full text

Fasting: Molecular Mechanisms and Clinical Applications by Longo, Valter D., Mattson, Mark P.

“…Fasting has been practiced for millennia, but, only recently, studies have shed light on its role in adaptive cellular responses that reduce oxidative damage…”
Get full text

Nutrition, longevity and disease: From molecular mechanisms to interventions by Longo, Valter D., Anderson, Rozalyn M.

“…Diet as a whole, encompassing food composition, calorie intake, and the length and frequency of fasting periods, affects the time span in which health and…”
Get full text

Fasting and cancer: molecular mechanisms and clinical application by Nencioni, Alessio, Caffa, Irene, Cortellino, Salvatore, Longo, Valter D.

“…The vulnerability of cancer cells to nutrient deprivation and their dependency on specific metabolites are emerging hallmarks of cancer. Fasting or…”
Get full text

Impact of Intermittent Fasting on Health and Disease Processes by Mattson, Mark P, Longo, Valter D, Harvie, Michelle

“…Abstract Humans in modern societies typically consume food at least three times daily, while laboratory animals are fed ad libitum. Overconsumption of food…”
Get full text

Extending Healthy Life Span--From Yeast to Humans by Fontana, Luigi, Partridge, Linda, Longo, Valter D

“…When the food intake of organisms such as yeast and rodents is reduced (dietary restriction), they live longer than organisms fed a normal diet. A similar…”
Get full text

Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients by Lee, C, Longo, V D

“…The dietary recommendation for cancer patients receiving chemotherapy, as described by the American Cancer Society, is to increase calorie and protein intake…”
Get full text

Replicative and Chronological Aging in Saccharomyces cerevisiae by Longo, Valter D., Shadel, Gerald S., Kaeberlein, Matt, Kennedy, Brian

“…Saccharomyces cerevisiae has directly or indirectly contributed to the identification of arguably more mammalian genes that affect aging than any other model…”
Get full text

Calorie restriction and cancer prevention: metabolic and molecular mechanisms by Longo, Valter D, Fontana, Luigi

“…An important discovery of recent years has been that lifestyle and environmental factors affect cancer initiation, promotion and progression, suggesting that…”
Get full text

Fasting and Caloric Restriction in Cancer Prevention and Treatment by Brandhorst, Sebastian, Longo, Valter D

“…Cancer is the second leading cause of death in the USA and among the leading major diseases in the world. It is anticipated to continue to increase because of…”
Get more information

When Fasting Gets Tough, the Tough Immune Cells Get Going—or Die by Buono, Roberta, Longo, Valter D.

“…Cycles of fasting reduce autoimmunity and activate lymphocyte-dependent killing of cancer cells, but the mechanisms remain poorly understood. Three studies in…”
Get full text

Protein and amino acid restriction, aging and disease: from yeast to humans by Mirzaei, Hamed, Suarez, Jorge A, Longo, Valter D

“…Highlights • Protein or AA restriction has been shown to be as potent as calorie restriction in extending healthspan in multiple model organisms. • AA…”
Get full text

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms by Choi, In Young, Piccio, Laura, Childress, Patra, Bollman, Bryan, Ghosh, Arko, Brandhorst, Sebastian, Suarez, Jorge, Michalsen, Andreas, Cross, Anne H., Morgan, Todd E., Wei, Min, Paul, Friedemann, Bock, Markus, Longo, Valter D.

“…Dietary interventions have not been effective in the treatment of multiple sclerosis (MS). Here, we show that periodic 3-day cycles of a fasting mimicking diet…”
Get full text

Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression by Cheng, Chia-Wei, Adams, Gregor B., Perin, Laura, Wei, Min, Zhou, Xiaoying, Lam, Ben S., Da Sacco, Stefano, Mirisola, Mario, Quinn, David I., Dorff, Tanya B., Kopchick, John J., Longo, Valter D.

“…Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA…”
Get full text

Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology by Rangan, Priya, Choi, Inyoung, Wei, Min, Navarrete, Gerardo, Guen, Esra, Brandhorst, Sebastian, Enyati, Nobel, Pasia, Gab, Maesincee, Daral, Ocon, Vanessa, Abdulridha, Maya, Longo, Valter D.

“…Dietary interventions are potentially effective therapies for inflammatory bowel diseases (IBDs). We tested the effect of 4-day fasting-mimicking diet (FMD)…”
Get full text

Intermittent and periodic fasting, longevity and disease by Longo, Valter D., Di Tano, Maira, Mattson, Mark P., Guidi, Novella

“…Intermittent and periodic fasting (IF and PF, respectively) are emerging as safe strategies to affect longevity and healthspan by acting on cellular aging and…”
Get full text

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity by Di Biase, Stefano, Lee, Changhan, Brandhorst, Sebastian, Manes, Brianna, Buono, Roberta, Cheng, Chia-Wei, Cacciottolo, Mafalda, Martin-Montalvo, Alejandro, de Cabo, Rafael, Wei, Min, Morgan, Todd E., Longo, Valter D.

“…Immune-based interventions are promising strategies to achieve long-term cancer-free survival. Fasting was previously shown to differentially sensitize tumors…”
Get full text

Meal frequency and timing in health and disease by Mattson, Mark P., Allison, David B., Fontana, Luigi, Harvie, Michelle, Longo, Valter D., Malaisse, Willy J., Mosley, Michael, Notterpek, Lucia, Ravussin, Eric, Scheer, Frank A. J. L., Seyfried, Thomas N., Varady, Krista A., Panda, Satchidananda

“…Although major research efforts have focused on how specific components of foodstuffs affect health, relatively little is known about a more fundamental aspect…”
Get full text

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers by Di Tano, Maira, Raucci, Franca, Vernieri, Claudio, Caffa, Irene, Buono, Roberta, Fanti, Maura, Brandhorst, Sebastian, Curigliano, Giuseppe, Nencioni, Alessio, de Braud, Filippo, Longo, Valter D.

“…Fasting-mimicking diets delay tumor progression and sensitize a wide range of tumors to chemotherapy, but their therapeutic potential in combination with…”
Get full text

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population by Levine, Morgan E., Suarez, Jorge A., Brandhorst, Sebastian, Balasubramanian, Priya, Cheng, Chia-Wei, Madia, Federica, Fontana, Luigi, Mirisola, Mario G., Guevara-Aguirre, Jaime, Wan, Junxiang, Passarino, Giuseppe, Kennedy, Brian K., Wei, Min, Cohen, Pinchas, Crimmins, Eileen M., Longo, Valter D.

“…Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1…”
Get full text