Search Results - "LONGMATE, Whitney M"

The epidermal integrin-mediated secretome regulates the skin microenvironment during tumorigenesis and repair by Longmate, Whitney M.

“…•Integrins are transmembrane receptors for extracellular matrix adhesion.•Keratinocyte integrins regulate factors such as matrix proteins, proteases, growth…”
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Suppression of Integrin α3β1 in Breast Cancer Cells Reduces Cyclooxygenase-2 Gene Expression and Inhibits Tumorigenesis, Invasion, and Cross-Talk to Endothelial Cells by MITCHELL, Kara, SVENSON, Kimberly B, LONGMATE, Whitney M, GKIRTZIMANAKI, Katerina, SADEJ, Rafal, XIANHUI WANG, JIHE ZHAO, ELIOPOULOS, Aristides G, BERDITCHEVSKI, Fedor, MICHAEL DIPERSIO, C

“…Integrin receptors for cell adhesion to extracellular matrix have important roles in promoting tumor growth and progression. Integrin α3β1 is highly expressed…”
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Epidermal Integrin α3β1 Regulates Tumor-Derived Proteases BMP-1, Matrix Metalloprotease-9, and Matrix Metalloprotease-3 by Longmate, Whitney M., Miskin, Rakshitha Pandulal, Van De Water, Livingston, DiPersio, C. Michael

“…As the major cell surface receptors for the extracellular matrix, integrins regulate adhesion and migration and have been shown to drive tumor growth and…”
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Integrin mutations in blistering skin diseases and related genetically engineered mouse models by Dhulipalla, Sanjana, Longmate, Whitney M.

“…As major receptors for cellular adhesion, integrins in the epidermis are critical to maintain skin integrity. Integrins α6β4 and α3β1 are among the most highly…”
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Keratinocyte Integrin α3β1 Promotes Secretion of IL-1α to Effect Paracrine Regulation of Fibroblast Gene Expression and Differentiation by Zheng, Rui, Longmate, Whitney M., DeFreest, Lori, Varney, Scott, Wu, Lei, DiPersio, C. Michael, Van De Water, Livingston

“…After cutaneous injury, keratinocytes secrete paracrine factors that regulate wound cell functions; dysregulation of this signaling can lead to wound…”
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Loss of Integrin α9β1 on Tumor Keratinocytes Enhances the Stromal Vasculature and Growth of Cutaneous Tumors by Varney, Scott D., Wu, Lei, Longmate, Whitney M., DiPersio, C. Michael, Van De Water, Livingston

“…Angiogenesis is critical to tumor progression, and the function of integrins in tumor angiogenesis is complex. In this study, we report that loss of integrin…”
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Keratinocyte integrin α3β1 induces expression of the macrophage stimulating factor, CSF-1, through a YAP/TEAD-dependent mechanism by Longmate, Whitney M., Norton, Emily, Duarte, Giesse Albeche, Wu, Lei, DiPersio, Mathieu R., Lamar, John M., DiPersio, C. Michael

“…The development of wound therapy targeting integrins is hampered by inadequate understanding of integrin function in cutaneous wound healing and the wound…”
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Integrin α3β1 on Tumor Keratinocytes Is Essential to Maintain Tumor Growth and Promotes a Tumor-Supportive Keratinocyte Secretome by Longmate, Whitney M., Varney, Scott, Power, Derek, Miskin, Rakshitha Pandulal, Anderson, Karl E., DeFreest, Lori, Van De Water, Livingston, DiPersio, C. Michael

“…The development of integrin-targeted cancer therapies is hindered by incomplete understanding of integrin function in tumor cells and the tumor…”
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Opposing Roles of Epidermal Integrins α3β1 and α9β1 in Regulation of mTLD/BMP-1–Mediated Laminin-γ2 Processing during Wound Healing by Longmate, Whitney M., Lyons, Scott P., DeFreest, Lori, Van De Water, Livingston, DiPersio, C. Michael

“…Proteolytic processing of the laminin-γ2 chain is a hallmark of basement membrane maturation in the skin. Integrin α3β1, a major receptor for epidermal…”
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Suppression of integrin α3β1 by α9β1 in the epidermis controls the paracrine resolution of wound angiogenesis by Longmate, Whitney M, Lyons, Scott P, Chittur, Sridar V, Pumiglia, Kevin M, Van De Water, Livingston, DiPersio, C Michael

“…Development of wound therapies is hindered by poor understanding of combinatorial integrin function in the epidermis. In this study, we generated mice with…”
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Reduced Fibulin-2 Contributes to Loss of Basement Membrane Integrity and Skin Blistering in Mice Lacking Integrin α3β1 in the Epidermis by Longmate, Whitney M., Monichan, Ruby, Chu, Mon-Li, Tsuda, Takeshi, Mahoney, My G., DiPersio, C.Michael

“…Deficient epidermal adhesion is a hallmark of blistering skin disorders and chronic wounds, implicating integrins as potential therapeutic targets. Integrin…”
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Keratinocyte Integrin α3β1 Promotes Efficient Healing of Wound Epidermis by Dhulipalla, Sanjana, Duarte, Giesse Albeche, Wu, Lei, DiPersio, Mathieu R., Lamar, John M., DiPersio, C. Michael, Longmate, Whitney M.

“…To date, studies of the role for epidermal integrin α3β1 in cutaneous wound re-epithelialization have produced conflicting results: wound studies in skin from…”
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Suppression of integrin α3[Beta]1 by α9[Beta]1 in the epidermis controls the paracrine resolution of wound angiogenesis by Longmate, Whitney M, Lyons, Scott P, Chittur, Sridar V, Pumiglia, Kevin M, Van De Water, Livingston, DiPersio, C Michael

“…Development of wound therapies is hindered by poor understanding of combinatorial integrin function in the epidermis. In this study, we generated mice with…”
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Reduced Fibulin-2 Contributes to Loss of Basement Membrane Integrity and Skin Blistering in Mice Lacking Integrin [alpha]3[beta]1 in the Epidermis by Longmate, Whitney M, Monichan, Ruby, Chu, Mon-li, Tsuda, Takeshi, Mahoney, My G, Dipersio, C Michael

“…Deficient epidermal adhesion is a hallmark of blistering skin disorders and chronic wounds, implicating integrins as potential therapeutic targets. Integrin…”
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Suppression of integrin α3β1 in breast cancer cells reduces COX-2 gene expression and inhibits tumorigenesis, invasion, and crosstalk to endothelial cells by Mitchell, Kara, Svenson, Kimberly B., Longmate, Whitney M., Gkirtzimanaki, Katerina, Sadej, Rafal, Wang, Xianhui, Zhao, Jihe, Eliopoulos, Aristides G., Berditchevski, Fedor, DiPersio, C. Michael

“…Integrin receptors for cell adhesion to extracellular matrix have important roles in promoting tumor growth and progression. Integrin α3β1 is highly expressed…”
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Suppression of integrin alpha3beta1 in breast cancer cells reduces cyclooxygenase-2 gene expression and inhibits tumorigenesis, invasion, and cross-talk to endothelial cells by Mitchell, Kara, Svenson, Kimberly B, Longmate, Whitney M, Gkirtzimanaki, Katerina, Sadej, Rafal, Wang, Xianhui, Zhao, Jihe, Eliopoulos, Aristides G, Berditchevski, Fedor, Dipersio, C Michael

“…Integrin receptors for cell adhesion to extracellular matrix have important roles in promoting tumor growth and progression. Integrin alpha3beta1 is highly…”
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