Search Results - "LOEKEN, M. R"

AMP-activated protein kinase mediates effects of oxidative stress on embryo gene expression in a mouse model of diabetic embryopathy by Wu, Y., Viana, M., Thirumangalathu, S., Loeken, M. R.

“…Aims/hypothesis Neural tube defects (NTDs) are a common malformation associated with diabetic embryopathy. Maternal hyperglycaemia-induced oxidative stress…”
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Oxidant regulation of gene expression and neural tube development: Insights gained from diabetic pregnancy on molecular causes of neural tube defects by CHANG, T. I, HORAL, M, JAIN, S. K, WANG, F, PATEL, R, LOEKEN, M. R

“…Maternal diabetes increases oxidative stress in embryos. Maternal diabetes also inhibits expression of embryonic genes, most notably, Pax-3, which is required…”
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A core outcome set for the treatment of pregnant women with pregestational diabetes: an international consensus study by Kgosidialwa, O, Bogdanet, D, Egan, AM, O'Shea, PM, Newman, C, Griffin, TP, McDonagh, C, O'Shea, C, Carmody, L, Cooray, SD, Anastasiou, E, Wender‐Ozegowska, E, Clarson, C, Spadola, A, Alvarado, F, Noctor, E, Dempsey, E, Napoli, A, Crowther, C, Galjaard, S, Loeken, MR, Maresh, MJA, Gillespie, P, Valk, H, Agostini, A, Biesty, L, Devane, D, Dunne, F

“…Objective To develop a core outcome set (COS) for randomised controlled trials (RCTs) evaluating the effectiveness of interventions for the treatment of…”
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Expression of the gene encoding the high-Km glucose transporter 2 by the early postimplantation mouse embryo is essential for neural tube defects associated with diabetic embryopathy by LI, R, THORENS, B, LOEKEN, M. R

“…Excess glucose transport to embryos during diabetic pregnancy causes congenital malformations. The early postimplantation embryo expresses the gene encoding…”
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Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy by FINE, E. L, HORAL, M, CHANG, T. I, FORTIN, G, LOEKEN, M. R

“…Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy. E L Fine , M Horal ,…”
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Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosis by Phelan, S. A., Ito, M., Loeken, M. R.

“…Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosis. S A Phelan , M Ito and M R Loeken Section on Molecular Biology, Joslin…”
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Expression of the gene encoding the high-K m glucose transporter 2 by the early postimplantation mouse embryo is essential for neural tube defects associated with diabetic embryopathy by Li, R., Thorens, B., Loeken, M. R.

“…Excess glucose transport to embryos during diabetic pregnancy causes congenital malformations. The early postimplantation embryo expresses the gene encoding…”
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Stimulation of endothelin-1 gene expression by insulin in endothelial cells by JAVIER OLIVER, F, DE LA RUBIA, G, FEENER, E. P, MU-EN LEE, LOEKEN, M. R, SHIBA, T, QUERTERMOUS, T, KING, G. L

“…The present study characterized the regulation of the genetic expression of the vasoactive peptide endothelin-1 (ET-1) by insulin in bovine aortic endothelial…”
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Free radicals and birth defects by Loeken, M. R.

“…Maternal diabetes significantly increases the risk for birth defects. Studies using animal models indicate that oxidative stress may play a causative role…”
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The adenovirus EIIA enhancer. Analysis of regulatory sequences and changes in binding activity of ATF and EIIF following adenovirus infection by LOEKEN, M. R, BRADY, J

“…Adenovirus EIIA upstream sequences which contain the binding sites for proteins ATF and EIIF act as an enhancer and can be trans-activated by both E1A and SV40…”
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Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis by Pani, Lydie, Horal, Melissa, Loeken, Mary R

“…Pax-3 is a transcription factor that is expressed in the neural tube, neural crest, and dermomyotome. We previously showed that apoptosis is associated with…”
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Neural tube defects in embryos of diabetic mice: Role of the Pax-3 gene and apoptosis by PHELAN, S. A, ITO, M, LOEKEN, M. R

“…Neural tube defects are among the most common of the malformations associated with diabetic embryopathy. To study the molecular mechanisms by which neural tube…”
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Expression of the gene encoding glycogen phosphorylase is elevated in diabetic rat skeletal muscle and is regulated by insulin and cyclic AMP by REYNET, C, KAHN, C. R, LOEKEN, M. R

“…Glycogen phosphorylase regulates the breakdown of glycogen into glucose, but as previous studies have demonstrated, the control of glycogen metabolism becomes…”
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Identification of Dep-1, a new gene regulated by the transcription factor pax-3, as a marker for altered embryonic gene expression during diabetic pregnancy by JIN CAI, PHELAN, S. A, HILL, A. L, LOEKEN, M. R

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Multiple, distinct trans-activation functions are encoded by the simian virus 40 large T and small t antigens, only some of which require the 82-residue amino-terminal common domain by LOEKEN, M. R

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Reduced expression of pax-3 is associated with overexpression of cdc46 in the mouse embryo by Hill, A L, Phelan, S A, Loeken, M R

“…CDC46/MCM5 encodes a protein that is highly conserved among yeast, plants, and animals. It is found in a complex which exhibits DNA replication licensing…”
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Involvement of simian virus 40 (SV40) small t antigen in trans activation of SV40 early and late promoters by BIKEL, I, LOEKEN, M. R

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Activation of the hexosamine pathway causes oxidative stress and abnormal embryo gene expression: Involvement in diabetic teratogenesis by Horal, Melissa, Zhang, Zhiquan, Stanton, Robert, Virkamäki, Antti, Loeken, Mary R.

“…BACKGROUND Oxidative stress is critical to the teratogenic effects of diabetic pregnancy, yet the specific biochemical pathways responsible for oxidative…”
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Simian virus 40 small t antigen trans activates the adenovirus E2A promoter by using mechanisms distinct from those used by adenovirus E1A by Loeken, M R

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Stimulation of the adenovirus E2 promoter by simian virus 40 T antigen or E1A occurs by different mechanisms by LOEKEN, M. R, KHOURY, G, BRADY, J

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