Search Results - "LOEFFLER, D. A"

Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions by Loeffler, D A, Connor, J R, Juneau, P L, Snyder, B S, Kanaley, L, DeMaggio, A J, Nguyen, H, Brickman, C M, LeWitt, P A

“…Oxidant-mediated damage is suspected to be involved in the pathogenesis of several neurodegenerative disorders. Iron promotes conversion of hydrogen peroxide…”
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Specific antibodies to soluble alpha-synuclein conformations in intravenous immunoglobulin preparations by Patrias, L.M, Klaver, A.C, Coffey, M.P, Loeffler, D.A

“…Alpha-synuclein is the major protein in Lewy bodies, the hallmark pathological finding in Parkinson's disease (PD) and dementia with Lewy bodies (DLB)…”
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A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains by Connor, J R, Snyder, B S, Arosio, P, Loeffler, D A, LeWitt, P

“…The brain requires a ready supply of iron for normal neurological function, but free iron is toxic. Consequently, iron bioavailability must be stringently…”
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Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders by Loeffler, D.A., LeWitt, P.A., Juneau, P.L., Sima, A.A.F., Nguyen, H.-U., DeMaggio, A.J., Brickman, C.M., Brewer, G.J., Dick, R.D., Troyer, M.D., Kanaley, L.

“…Ceruloplasmin (CP), the major plasma anti-oxidant and copper transport protein, is synthesized in several tissues, including the brain. We compared regional…”
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L‐DOPA Does Not Enhance Hydroxyl Radical Formation in the Nigrostriatal Dopamine System of Rats with a Unilateral 6‐Hydroxydopamine Lesion by Camp, Dianne M., Loeffler, David A., LeWitt, Pater A.

“…The debate about the toxicity of L‐DOPA to dopaminergic neurons has not been resolved. Even though enzymatic and nonenzymatic metabolism of L‐DOPA can produce…”
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Influence of tumour physico-chemical conditions on interleukin-2-stimulated lymphocyte proliferation by LOEFFLER, D. A, JUNEAU, P. L, MASSERANT, S

“…The proliferative response of murine lymphocytes to interleukin-2 (IL-2) was examined under physico-chemical conditions present in solid tumours, namely low…”
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Ceruloplasmin immunoreactivity in neurodegenerative disorders by Loeffler, D A, Sima, A A, LeWitt, P A

“…Ceruloplasmin (CP) is a 132 kd cuproprotein which, together with transferrin, provides the majority of anti-oxidant capacity in serum. Increased iron…”
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Purine-induced alterations of dopamine metabolism in rat pheochromocytoma PC12 cells by Loeffler, D.A, Camp, D.M, Juneau, P.L, Harel, E, LeWitt, P.A

“…Studies with cerebrospinal fluid from subjects with Parkinson’s disease suggest that purine abnormalities may be present in this disorder. The effects of…”
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Cerebrospinal Fluid C3a Increases with Age, But Does Not Increase Further in Alzheimer’s Disease by Loeffler, D.A, Brickman, C.M, Juneau, P.L, Perry, M.F, Pomara, N, LeWitt, P.A

“…Complement activation is present in the brain in Alzheimer’s disease (AD), and C1q concentrations are decreased in AD cerebrospinal fluid (CSF). To determine…”
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Ceruloplasmin is increased in cerebrospinal fluid in Alzheimer's disease but not Parkinson's disease by Loeffler, D A, DeMaggio, A J, Juneau, P L, Brickman, C M, Mashour, G A, Finkelman, J H, Pomara, N, LeWitt, P A

“…Although the pathophysiology of Alzheimer's disease (AD) and Parkinson's disease (PD) is unknown, altered brain antioxidative mechanisms have been found in…”
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Effects of enhanced striatal dopamine turnover in vivo on glutathione oxidation by Loeffler, D A, DeMaggio, A J, Juneau, P L, Havaich, M K, LeWitt, P A

“…In Parkinson's disease (PD), a compensatory increase in dopamine (DA) turnover occurs in the remaining nigrostriatal dopaminergic neurons, resulting in greater…”
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Altered Guanosine and Guanine Concentrations in Rabbit Striatum Following Increased Dopamine Turnover by Loeffler, D.A, LeWitt, P.A, Juneau, P.L, Camp, D.M, DeMaggio, A.J, Milbury, P, Matson, W.R, Rathbone, M.P

“…The significance of guanine nucleotides and nucleosides in neurodegenerative disorders is suggested by recent reports that these molecules enhance neurite…”
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Influence of repeated levodopa administration on rabbit striatal serotonin metabolism, and comparison between striatal and CSF alterations by LOEFFLER, D. A, LEWITT, P. A, JUNEAU, P. L, CAMP, D. M, DEMAGGIO, A. J, HAVAICH, M. K, MILBURY, P. E, MATSON, W. R

“…Parkinson's disease (PD) is characterized by decreased striatal dopamine, but serotonin (5-HT) is also reduced. Because 5-HT decreases following a single…”
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Time-dependent effects of levodopa on regional brain dopamine metabolism and lipid peroxidation by Loeffler, D.A, LeWitt, P.A, Juneau, P.L, Camp, D.M, Arnold, L.A, Hyland, K

“…Levodopa treatment in Parkinson’s disease has been suggested to contribute to disease progression through free radical generation. We compared the time course…”
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Measurement of acute phase proteins in the rat brain : Contribution of vascular contents by LOEFFLER, D. A, LINDER, M. C, ZAMANY, M, HAREL, E, PAUL, M. A, BAUMANN, H, LEWITT, P. A

“…A localized acute phase response occurs in the brain in Alzheimer's disease. Acute phase proteins have previously been measured in brain homogenates to…”
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Immunocytochemical detection of anti-hippocampal antibodies in Alzheimer's disease and normal cerebrospinal fluid by LOEFFLER, D. A, JUNEAU, P. L, NGUYEN, H.-U, NAJMAN, D, POMARA, N, LEWITT, P. A

“…Immunocytochemical staining was performed to investigate the presence of anti-hippocampal antibodies in cerebrospinal fluid (CSF) from patients with probable…”
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Enzyme-linked immunosorbent assay for detection of leukocidin toxin from Staphylococcus aureus in bovine milk samples by Loeffler, D.A, Creasy, M.T, Norcross, N.L, Paape, M.J

“…Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Lymphocytic infiltration and cytotoxicity under hypoxic conditions in the EMT6 mouse mammary tumor by Loeffler, D A, Keng, P C, Baggs, R B, Lord, E M

“…Infiltration of lymphocytes, neutrophils and macrophages was evaluated in hypoxic and well-oxygenated areas of the EMT6 mouse mammary adenocarcinoma, by in…”
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Markers of dopamine depletion and compensatory response in striatum and cerebrospinal fluid by LOEFFLER, D. A, LEWITT, P. A, DEMAGGIO, A. J, JUNEAU, P. L, MILBURY, P. E, MATSON, W. R

“…Though depletion of CSF homovanillic acid (HVA) concentration has often been regarded as a direct indicator of dopamine (DA) deficiency in Parkinson's Disease…”
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Levodopa administration to normal rats: influence on striatal oxidized glutathione concentration by Loeffler, D A, Demaggio, A J, Juneau, P L, Havaich, M, Lewitt, P A

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