Search Results - "LOCKWOOD, William W"

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins by Lockwood, William W., Zejnullahu, Kreshnik, Bradner, James E., Varmus, Harold

“…Bromodomain and extra terminal domain (BET) proteins function as epigenetic signaling factors that associate with acetylated histones and facilitate…”
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Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance by Lim, Jonathan K. M., Delaidelli, Alberto, Minaker, Sean W., Zhang, Hai-Feng, Colovic, Milena, Yang, Hua, Negri, Gian Luca, von Karstedt, Silvia, Lockwood, William W., Schaffer, Paul, Leprivier, Gabriel, Sorensen, Poul H.

“…The RAS family of proto-oncogenes are among the most commonly mutated genes in human cancers and predict poor clinical outcome. Several mechanisms underlying…”
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Expression of the lncRNA Maternally Expressed Gene 3 (MEG3) Contributes to the Control of Lung Cancer Cell Proliferation by the Rb Pathway by Kruer, Traci L, Dougherty, Susan M, Reynolds, Lindsey, Long, Elizabeth, de Silva, Tanya, Lockwood, William W, Clem, Brian F

“…Maternally expressed gene 3 (MEG3, mouse homolog Gtl2) encodes a long noncoding RNA (lncRNA) that is expressed in many normal tissues, but is suppressed in…”
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Activation of KRAS Mediates Resistance to Targeted Therapy in MET Exon 14-mutant Non-small Cell Lung Cancer by Suzawa, Ken, Offin, Michael, Lu, Daniel, Kurzatkowski, Christopher, Vojnic, Morana, Smith, Roger S, Sabari, Joshua K, Tai, Huichun, Mattar, Marissa, Khodos, Inna, de Stanchina, Elisa, Rudin, Charles M, Kris, Mark G, Arcila, Maria E, Lockwood, William W, Drilon, Alexander, Ladanyi, Marc, Somwar, Romel

“…exon 14 splice site alterations that cause exon skipping at the mRNA level ( ex14) are actionable oncogenic drivers amenable to therapy with MET tyrosine…”
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Uncovering molecular features driving lung adenocarcinoma heterogeneity in patients who formerly smoked by Wang, Peiyao, Ng, Raymond, Lam, Stephen, Lockwood, William W

“…An increasing proportion of lung adenocarcinoma (LUAD) occurs in patients even after they have stopped smoking. Here, we aimed to determine whether tobacco…”
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New insights into the biology and development of lung cancer in never smokers-implications for early detection and treatment by Wang, Peiyao, Sun, Sophie, Lam, Stephen, Lockwood, William W

“…Lung cancer is the leading cause of cancer deaths worldwide. Despite never smokers comprising between 10 and 25% of all cases, lung cancer in never smokers…”
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Response to ERBB3-Directed Targeted Therapy in NRG1 -Rearranged Cancers by Drilon, Alexander, Somwar, Romel, Mangatt, Biju P, Edgren, Henrik, Desmeules, Patrice, Ruusulehto, Anja, Smith, Roger S, Delasos, Lukas, Vojnic, Morana, Plodkowski, Andrew J, Sabari, Joshua, Ng, Kenneth, Montecalvo, Joseph, Chang, Jason, Tai, Huichun, Lockwood, William W, Martinez, Victor, Riely, Gregory J, Rudin, Charles M, Kris, Mark G, Arcila, Maria E, Matheny, Christopher, Benayed, Ryma, Rekhtman, Natasha, Ladanyi, Marc, Ganji, Gopinath

“…rearrangements are oncogenic drivers that are enriched in invasive mucinous adenocarcinomas (IMA) of the lung. The oncoprotein binds ERBB3-ERBB2 heterodimers…”
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Lung Cancer Cell Lines as Tools for Biomedical Discovery and Research by Gazdar, Adi F., Girard, Luc, Lockwood, William W., Lam, Wan L., Minna, John D.

“…Lung cancer cell lines have made a substantial contribution to lung cancer translational research and biomedical discovery. A systematic approach to initiating…”
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Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells by Unni, Arun M, Harbourne, Bryant, Oh, Min Hee, Wild, Sophia, Ferrarone, John R, Lockwood, William W, Varmus, Harold

“…Synthetic lethality results when mutant KRAS and EGFR proteins are co-expressed in human lung adenocarcinoma (LUAD) cells, revealing the biological basis for…”
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Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma by Unni, Arun M, Lockwood, William W, Zejnullahu, Kreshnik, Lee-Lin, Shih-Queen, Varmus, Harold

“…Human lung adenocarcinomas (LUAD) contain mutations in EGFR in ∼15% of cases and in KRAS in ∼30%, yet no individual adenocarcinoma appears to carry activating…”
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Lung Cancer Signatures in Plasma Based on Proteome Profiling of Mouse Tumor Models by Taguchi, Ayumu, Politi, Katerina, Pitteri, Sharon J., Lockwood, William W., Faça, Vitor M., Kelly-Spratt, Karen, Wong, Chee-Hong, Zhang, Qing, Chin, Alice, Park, Kwon-Sik, Goodman, Gary, Gazdar, Adi F., Sage, Julien, Dinulescu, Daniela M., Kucherlapati, Raju, DePinho, Ronald A., Kemp, Christopher J., Varmus, Harold E., Hanash, Samir M.

“…We investigated the potential of in-depth quantitative proteomics to reveal plasma protein signatures that reflect lung tumor biology. We compared plasma…”
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Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma by Enfield, Katey S. S., Marshall, Erin A., Anderson, Christine, Ng, Kevin W., Rahmati, Sara, Xu, Zhaolin, Fuller, Megan, Milne, Katy, Lu, Daniel, Shi, Rocky, Rowbotham, David A., Becker-Santos, Daiana D., Johnson, Fraser D., English, John C., MacAulay, Calum E., Lam, Stephen, Lockwood, William W., Chari, Raj, Karsan, Aly, Jurisica, Igor, Lam, Wan L.

“…Gene function in cancer is often cell type-specific. The epithelial cell-specific transcription factor ELF3 is a documented tumor suppressor in many epithelial…”
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Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells by Soh, Junichi, Okumura, Naoki, Lockwood, William W, Yamamoto, Hiromasa, Shigematsu, Hisayuki, Zhang, Wei, Chari, Raj, Shames, David S, Tang, Ximing, MacAulay, Calum, Varella-Garcia, Marileila, Vooder, Tõnu, Wistuba, Ignacio I, Lam, Stephen, Brekken, Rolf, Toyooka, Shinichi, Minna, John D, Lam, Wan L, Gazdar, Adi F

“…Activating mutations in one allele of an oncogene (heterozygous mutations) are widely believed to be sufficient for tumorigenesis. However, mutant allele…”
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PIK3CA Mutations and Copy Number Gains in Human Lung Cancers by YAMAMOTO, Hiromasa, SHIGEMATSU, Hisayuki, LEE, Huei, TOYOOKA, Shinichi, DATE, Hiroshi, LAM, Wan L, MINNA, John D, GAZDAR, Adi F, NOMURA, Masaharu, LOCKWOOD, William W, SATO, Mitsuo, OKUMURA, Naoki, SOH, Junichi, SUZUKI, Makoto, WISTUBA, Ignacio I, FONG, Kwun M

“…We investigated the frequency and function of mutations and increased copy number of the PIK3CA gene in lung cancers. PIK3CA mutations are one of the most…”
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Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines by Somwar, Romel, Erdjument-Bromage, Hediye, Larsson, Erik, Shum, David, Lockwood, William W, Yang, Guangli, Sander, Chris, Ouerfelli, Ouathek, Tempst, Paul J, Djaballah, Hakim, Varmus, Harold E

“…We previously described four small molecules that reduced the growth of lung adenocarcinoma cell lines with either epidermal growth factor receptor (EGFR) or…”
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Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4 by Calder, Jack, Nagelberg, Amy, Luu, Jennifer, Lu, Daniel, Lockwood, William W.

“…Targeting the epigenome to modulate gene expression programs driving cancer development has emerged as an exciting avenue for therapeutic intervention…”
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Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer by Inoue, Yusuke, Nikolic, Ana, Farnsworth, Dylan, Shi, Rocky, Johnson, Fraser D, Liu, Alvin, Ladanyi, Marc, Somwar, Romel, Gallo, Marco, Lockwood, William W

“…Lineage transformation between lung cancer subtypes is a poorly understood phenomenon associated with resistance to treatment and poor patient outcomes. Here,…”
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Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells by Johnson, Fraser D., Ferrarone, John, Liu, Alvin, Brandstädter, Christina, Munuganti, Ravi, Farnsworth, Dylan A., Lu, Daniel, Luu, Jennifer, Sihota, Tianna, Jansen, Sophie, Nagelberg, Amy, Shi, Rocky, Forcina, Giovanni C., Zhang, Xu, Cheng, Grace S.W., Spencer Miko, Sandra E., de Rappard-Yuswack, Georgia, Sorensen, Poul H., Dixon, Scott J., Guha, Udayan, Becker, Katja, Djaballah, Hakim, Somwar, Romel, Varmus, Harold, Morin, Gregg B., Lockwood, William W.

“…Phenotype-based screening can identify small molecules that elicit a desired cellular response, but additional approaches are required to characterize their…”
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Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1 by Beverly, Levi J, Lockwood, William W, Shah, Parag P, Erdjument-Bromage, Hediye, Varmus, Harold

“…We have previously shown that all six members of the anti-apoptotic BCL2 gene family can cooperate with (myelocytomatosis oncogene) MYC in a mouse model of…”
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Delineating spatial cell-cell interactions in the solid tumour microenvironment through the lens of highly multiplexed imaging by Cohn, David E., Forder, Aisling, Marshall, Erin A., Vucic, Emily A., Stewart, Greg L., Noureddine, Kouther, Lockwood, William W., MacAulay, Calum E., Guillaud, Martial, Lam, Wan L.

“…The growth and metastasis of solid tumours is known to be facilitated by the tumour microenvironment (TME), which is composed of a highly diverse collection of…”
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