Search Results - "LOCKERBIE, Owen"

Riboflavin and UV-Light Based Pathogen Reduction: Extent and Consequence of DNA Damage at the Molecular Level by Kumar, Vijay, Lockerbie, Owen, Keil, Shawn D., Ruane, Patrick H., Platz, Matthew S., Martin, Christopher B., Ravanat, Jean-Luc, Cadet, Jean, Goodrich, Raymond P.

“…We are developing a technology based on the combined application of riboflavin (RB) and light for inactivating pathogens in blood products while retaining the…”
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Sequence-dependent inhibition of human colon cancer cell growth and of prosurvival pathways by oxaliplatin in combination with ZD6474 (Zactima), an inhibitor of VEGFR and EGFR tyrosine kinases by Troiani, Teresa, Lockerbie, Owen, Morrow, Mark, Ciardiello, Fortunato, Eckhardt, S Gail

“…To date, clinical studies combining the new generation of targeted therapies and chemotherapy have had mixed results. Preclinical studies can be used to…”
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Investigation of Two Dosing Schedules of Vandetanib (ZD6474), an Inhibitor of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor Signaling, in Combination with Irinotecan in a Human Colon Cancer Xenograft Model by TROIANI, Teresa, SERKOVA, Natalie J, GUSTAFSON, Daniel L, HENTHORN, Thomas K, LOCKERBIE, Owen, MERZ, Andrea, LONG, Michael, MORROW, Mark, CIARDIELLO, Fortunato, ECKHARDT, S. Gail

“…Purpose: This in vivo study was designed to determine the optimal doses and schedules of vandetanib, a dual epidermal growth factor receptor (EGFR)-vascular…”
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Novel Alkylating Agent Melflufen Displays Potent Efficacy in Plasma Cell Leukemia Samples and Other High-Risk Subtypes of Multiple Myeloma by Idler, Beau M, Perez De Acha, Olivia, Lockerbie, Owen, Flanagan, Ken, Lehmann, Fredrik, Forsberg, Peter A, Mark, Tomer M, Sherbenou, Daniel W.

“…Introduction: Despite the progress that has been made for standard risk multiple myeloma (MM), subsets of patients with the most advanced and aggressive plasma…”
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Regulated Plasmalemmal Expansion in Nerve Growth Cones by Lockerbie, R. Owen, Miller, Virginia E., Pfenninger, Karl H.

“…To study the mechanisms underlying plasmalemmal expansion in the nerve growth cone, a cellfree assay was developed to quantify membrane addition, using ligand…”
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Evaluation of platelet mitochondria integrity after treatment with Mirasol pathogen reduction technology by Li, Junzhi, Lockerbie, Owen, De Korte, Dirk, Rice, Joe, McLean, Robyn, Goodrich, Raymond P.

“…BACKGROUND: Previous studies showed that Mirasol (Navigant Biotechnologies, Inc.) pathogen reduction technology (PRT) treatment resulted in an increase in…”
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Biochemical pharmacology of isolated neuronal growth cones: implications for synaptogenesis by Lockerbie, R O

“…The neuronal growth cone is critical to the establishment of neuronal polarity through its motile, pathfinding and target recognition properties exhibited…”
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High price of neglect by Lockerbie, Owen

“…The founding member of the Newmarket Protection Society outlines some of the planning and development issues facing the suburb. Source: National Library of New…”
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gamma-Aminobutyric acidA (GABAA) receptors modulate [3H]GABA release from isolated neuronal growth cones in the rat by Lockerbie, R O, Gordon-Weeks, P R

“…Potassium-induced release of gamma-[3H]aminobutyric acid [( 3H]GABA) from a growth cone-enriched fraction isolated from neonatal rat forebrain was inhibited by…”
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An isolated growth cone-enriched fraction from developing rat brain has substance P binding sites by Lockerbie, R O, Beaujouan, J C, Saffroy, M, Glowinski, J

“…A fraction enriched in neuronal growth cones isolated from developing rat forebrain was shown to possess binding sites for the substance P analog,…”
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Isolated neuronal growth cones from developing rat forebrain possess adenylate cyclase activity which can be augmented by various receptor agonists by Lockerbie, R O, Hervé, D, Blanc, G, Tassin, J P, Glowinski, J

“…Isolated neuronal growth cones from neonatal rat forebrain were found to contain a high specific activity of adenylate cyclase (61 pmol cyclic AMP/min/mg…”
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Growth cones isolated from developing rat forebrain: uptake and release of GABA and noradrenaline by Lockerbie, R O, Gordon-Weeks, P R, Pearce, B R

“…A growth cone-enriched fraction isolated from neonatal rat forebrain was shown to accumulate gamma-amino [3H]butyric acid ([3H]-GABA) and [3H]noradrenaline…”
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