Search Results - "LOCKER, Joseph"

Pharmacologic Inhibition of Epidermal Growth Factor Receptor Suppresses Nonalcoholic Fatty Liver Disease in a Murine Fast‐Food Diet Model by Bhushan, Bharat, Banerjee, Swati, Paranjpe, Shirish, Koral, Kelly, Mars, Wendy M., Stoops, John W., Orr, Anne, Bowen, William C., Locker, Joseph, Michalopoulos, George K.

“…Epidermal growth factor receptor (EGFR) is a critical regulator of hepatocyte proliferation and liver regeneration. Our recent work indicated that EGFR can…”
Get full text

Hdac1 Regulates Differentiation of Bipotent Liver Progenitor Cells During Regeneration via Sox9b and Cdk8 by Ko, Sungjin, Russell, Jacquelyn O., Tian, Jianmin, Gao, Ce, Kobayashi, Makoto, Feng, Rilu, Yuan, Xiaodong, Shao, Chen, Ding, Huiguo, Poddar, Minakshi, Singh, Sucha, Locker, Joseph, Weng, Hong-Lei, Monga, Satdarshan P., Shin, Donghun

“…Upon liver injury in which hepatocyte proliferation is compromised, liver progenitor cells (LPCs), derived from biliary epithelial cells (BECs), differentiate…”
Get full text

Genome Wide Methylome Alterations in Lung Cancer by Mullapudi, Nandita, Ye, Bin, Suzuki, Masako, Fazzari, Melissa, Han, Weiguo, Shi, Miao K, Marquardt, Gaby, Lin, Juan, Wang, Tao, Keller, Steven, Zhu, Changcheng, Locker, Joseph D, Spivack, Simon D

“…Aberrant cytosine 5-methylation underlies many deregulated elements of cancer. Among paired non-small cell lung cancers (NSCLC), we sought to profile DNA…”
Get full text

Cubilin-, megalin-, and Dab2-dependent transcription revealed by CRISPR/Cas9 knockout in kidney proximal tubule cells by Long, Kimberly R, Rbaibi, Youssef, Bondi, Corry D, Ford, B Rhodes, Poholek, Amanda C, Boyd-Shiwarski, Cary R, Tan, Roderick J, Locker, Joseph D, Weisz, Ora A

“…The multiligand receptors megalin ( ) and cubilin ( ) and their endocytic adaptor protein Dab2 ( ) play essential roles in maintaining the integrity of the…”
Get more information

Biliary fibrosis drives liver repopulation and phenotype transition of transplanted hepatocytes by Yovchev, Mladen I, Locker, Joseph, Oertel, Michael

“…Background & Aims Current research focuses on developing alternative strategies to restore decreased liver mass prior to the onset of end-stage liver disease…”
Get full text

Constitutive Activation of the Human Aryl Hydrocarbon Receptor in Mice Promotes Hepatocarcinogenesis Independent of Its Coactivator Gadd45b by Lu, Peipei, Cai, Xinran, Guo, Yan, Xu, Meishu, Tian, Jianmin, Locker, Joseph, Xie, Wen

“…Abstract 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or dioxin, is a potent liver cancer promoter through its sustained activation of the aryl hydrocarbon…”
Get full text

Repopulation of the fibrotic/cirrhotic rat liver by transplanted hepatic stem/progenitor cells and mature hepatocytes by Yovchev, Mladen I., Xue, Yuhua, Shafritz, David A., Locker, Joseph, Oertel, Michael

“…Considerable progress has been made in developing antifibrotic agents and other strategies to treat liver fibrosis; however, significant long‐term restoration…”
Get full text

Transcriptional Programs Driving Shear Stress-Induced Differentiation of Kidney Proximal Tubule Cells in Culture by Park, Hyun Jung, Fan, Zhenjiang, Bai, Yulong, Ren, Qidong, Rbaibi, Youssef, Long, Kimberly R, Gliozzi, Megan L, Rittenhouse, Natalie, Locker, Joseph D, Poholek, Amanda C, Weisz, Ora A

“…Cultured cell models are an essential complement to dissecting kidney proximal tubule (PT) function in health and disease but do not fully recapitulate key…”
Get full text

Shear stress and oxygen availability drive differential changes in opossum kidney proximal tubule cell metabolism and endocytosis by Ren, Qidong, Gliozzi, Megan L., Rittenhouse, Natalie L., Edmunds, Lia R., Rbaibi, Youssef, Locker, Joseph D., Poholek, Amanda C., Jurczak, Michael J., Baty, Catherine J., Weisz, Ora A.

“…Kidney proximal tubule (PT) cells have high‐metabolic demands to drive the extraordinary ion and solute transport, water reabsorption, and endocytic uptake…”
Get full text

The transcriptome of the Didelphis virginiana opossum kidney OK proximal tubule cell line by Eshbach, Megan L, Sethi, Rahil, Avula, Raghunandan, Lamb, Janette, Hollingshead, Deborah J, Finegold, David N, Locker, Joseph D, Chandran, Uma R, Weisz, Ora A

“…The OK cell line derived from the kidney of a female opossum has proven to be a useful model in which to investigate the unique regulation of ion transport and…”
Get more information

Failure of Postnatal Ductus Arteriosus Closure in Prostaglandin Transporter-Deficient Mice by CHANG, Hee-Yoon, LOCKER, Joseph, RUN LU, SCHUSTER, Victor L

“…Prostaglandin E(2) (PGE(2)) plays a major role both in maintaining patency of the fetal ductus arteriosus and in closure of the ductus arteriosus after birth…”
Get full text

Binding of Drug-Activated CAR/Nr1i3 Alters Metabolic Regulation in the Liver by Tian, Jianmin, Marino, Rebecca, Johnson, Carla, Locker, Joseph

“…The constitutive androstane receptor (CAR/Nr1i3) regulates detoxification of drugs and other xenobiotics by the liver. Binding of these compounds, activating…”
Get full text

Skp2 is required for survival of aberrantly proliferating Rb1 -deficient cells and for tumorigenesis in Rb1 +/− mice by Locker, Joseph, Ji, Peng, Xu, Xiaoliang, Nakayama, Keiko, Cobrinik, David, Nakayama, Keiich I, Zhu, Liang, Sellers, Rani S, Sun, Daqian, Wang, Hongbo, Bauzon, Frederick

“…Liang Zhu and colleagues report that inactivation of Skp2, a target of the pRb tumor suppressor, completely prevented tumorigenesis in tumor-prone mice with…”
Get full text

Antagonizing Activin A/p15INK4b Signaling as Therapeutic Strategy for Liver Disease by Mekala, Sowmya, Rai, Ravi, Reed, Samantha Loretta, Bowen, Bill, Michalopoulos, George K., Locker, Joseph, Raeman, Reben, Oertel, Michael

“…Background/Aim: Activin A is involved in the pathogenesis of human liver diseases, but its therapeutic targeting is not fully explored. Here, we tested the…”
Get full text

Nkx2.9 Contributes to Mid-Hindbrain Patterning by Regulation of mdDA Neuronal Cell-Fate and Repression of a Hindbrain-Specific Cell-Fate by Kouwenhoven, Willemieke M, von Oerthel, Lars, Gruppilo, Maria, Tian, Jianmin, Wagemans, Cindy M R J, Houwers, Imke G J, Locker, Joseph, Mesman, Simone, Smidt, Marten P

“…is a member of the NK homeobox family and resembles both in homology and expression pattern. However, while is required for development of serotonergic…”
Get full text

A Nonhuman Primate Model of Human Radiation-Induced Venocclusive Liver Disease and Hepatocyte Injury by Yannam, Govardhana Rao, MD, Han, Bing, MD, Setoyama, Kentaro, DVM, PhD, Yamamoto, Toshiyuki, MD, Ito, Ryotaro, MD, Brooks, Jenna M., BS, Guzman-Lepe, Jorge, MD, Galambos, Csaba, MD, PhD, Fong, Jason V., MD, Deutsch, Melvin, MD, Quader, Mubina A., PhD, Yamanouchi, Kosho, MD, PhD, Kabarriti, Rafi, MD, Mehta, Keyur, MD, Soto-Gutierrez, Alejandro, MD, PhD, Roy-Chowdhury, Jayanta, MD, Locker, Joseph, MD, PhD, Abe, Michio, MD, Enke, Charles A., MD, Baranowska-Kortylewicz, Janina, PhD, Solberg, Timothy D., PhD, Guha, Chandan, MBBS, PhD, Fox, Ira J., MD

“…Background Human liver has an unusual sensitivity to radiation that limits its use in cancer therapy or in preconditioning for hepatocyte transplantation…”
Get full text

Both Gene Amplification and Allelic Loss Occur at 14q13.3 in Lung Cancer by HARRIS, Thomas, QIULU PAN, SIRONI, Juan, LUTZ, Dionne, JIANMIN TIAN, SAPKAR, Jana, PEREZ-SOLER, Roman, KELLER, Steven, LOCKER, Joseph

“…Because loss of Nkx2-8 increases lung cancer in the mouse, we studied suppressive mechanisms in human lung cancer. NKX2-8 is located within 14q13.3, adjacent…”
Get full text

Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal trancriptional regulatory region in an antifolate-resistant HeLa cell line by Diop-Bove, Ndeye Khady, Wu, Julia, Zhao, Rongbao, Locker, Joseph, Goldman, I. David

“…This laboratory recently identified a novel proton-coupled folate transporter (PCFT) that mediates intestinal folate absorption and transport of folates into…”
Get full text

Precise let-7 expression levels balance organ regeneration against tumor suppression by Wu, Linwei, Nguyen, Liem H, Zhou, Kejin, de Soysa, T Yvanka, Li, Lin, Miller, Jason B, Tian, Jianmin, Locker, Joseph, Zhang, Shuyuan, Shinoda, Gen, Seligson, Marc T, Zeitels, Lauren R, Acharya, Asha, Wang, Sam C, Mendell, Joshua T, He, Xiaoshun, Nishino, Jinsuke, Morrison, Sean J, Siegwart, Daniel J, Daley, George Q, Shyh-Chang, Ng, Zhu, Hao

“…The in vivo roles for even the most intensely studied microRNAs remain poorly defined. Here, analysis of mouse models revealed that let-7, a large and ancient…”
Get full text

Rybp/DEDAF Is Required for Early Postimplantation and for Central Nervous System Development by Pirity, Melinda K., Locker, Joseph, Schreiber-Agus, Nicole

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text