Search Results - "LOCHHEAD, J"

Intranasal delivery of biologics to the central nervous system by Lochhead, Jeffrey J., Thorne, Robert G.

“…Treatment of central nervous system (CNS) diseases is very difficult due to the blood–brain barrier's (BBB) ability to severely restrict entry of all but…”
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Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders by Lochhead, Jeffrey J, Yang, Junzhi, Ronaldson, Patrick T, Davis, Thomas P

“…The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy critical to neuronal function while simultaneously excluding…”
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SSRI-associated optic neuropathy by Lochhead, J

“…Purpose We report five cases of optic neuropathy (ON) identified over a 2-year period within an island population of 140 000. These cases display…”
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Rapid Transport within Cerebral Perivascular Spaces Underlies Widespread Tracer Distribution in the Brain after Intranasal Administration by Lochhead, Jeffrey J, Wolak, Daniel J, Pizzo, Michelle E, Thorne, Robert G

“…The intranasal administration route is increasingly being used as a noninvasive method to bypass the blood—brain barrier because evidence suggests small…”
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Distribution of insulin in trigeminal nerve and brain after intranasal administration by Lochhead, Jeffrey J., Kellohen, Kathryn L., Ronaldson, Patrick T., Davis, Thomas P.

“…In the brain, insulin acts as a growth factor, regulates energy homeostasis, and is involved in learning and memory acquisition. Many central nervous system…”
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Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: Distribution, dose-response, and mechanisms of delivery by Kumar, Niyanta N., Lochhead, Jeffrey J., Pizzo, Michelle E., Nehra, Geetika, Boroumand, Sam, Greene, Gretchen, Thorne, Robert G.

“…The intranasal route has been hypothesized to circumvent the blood-brain and blood-cerebrospinal fluid barriers, allowing entry into the brain via…”
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Perivascular and Perineural Pathways Involved in Brain Delivery and Distribution of Drugs after Intranasal Administration by Lochhead, Jeffrey J, Davis, Thomas P

“…One of the most challenging aspects of treating disorders of the central nervous system (CNS) is the efficient delivery of drugs to their targets within the…”
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Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System by Lochhead, Jeffrey J., Ronaldson, Patrick T., Davis, Thomas P.

“…A functional blood-brain barrier (BBB) is necessary to maintain central nervous system (CNS) homeostasis. Many diseases affecting the CNS, however, alter the…”
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Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation by Lochhead, Jeffrey J, McCaffrey, Gwen, Quigley, Colleen E, Finch, Jessica, DeMarco, Kristin M, Nametz, Nicole, Davis, Thomas P

“…The blood–brain barrier (BBB) has a critical role in central nervous system homeostasis. Intercellular tight junction (TJ) protein complexes of the brain…”
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An Innovative Portable Biosensor System for the Rapid Detection of Freshwater Cyanobacterial Algal Bloom Toxins by Bickman, Sarah R, Campbell, Katrina, Elliott, Christopher, Murphy, Caroline, O’Kennedy, Richard, Papst, Philip, Lochhead, Michael J

“…Harmful algal blooms in freshwater systems are increasingly common and present threats to drinking water systems, recreational waters, and ecosystems. A highly…”
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Increasing incidence of eosinophilic esophagitis in Sweden: a nationwide population study by Garber, John J., Lochhead, Paul J., Uchida, Amiko M., Roelstraete, Bjorn, Bergman, David, Clements, Mark S., Ludvigsson, Jonas F.

“…Background Eosinophilic esophagitis (EoE) is a chronic inflammatory condition of the esophagus associated with dysphagia and esophageal fibrosis. The incidence…”
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Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery by Kumar, Niyanta N., Gautam, Mohan, Lochhead, Jeffrey J., Wolak, Daniel J., Ithapu, Vamsi, Singh, Vikas, Thorne, Robert G.

“…Intranasal administration provides a non-invasive drug delivery route that has been proposed to target macromolecules either to the brain via direct…”
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βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling by Kwak, Eun-A, Pan, Christopher C., Ramonett, Aaron, Kumar, Sanjay, Cruz-Flores, Paola, Ahmed, Tasmia, Ortiz, Hannah R., Lochhead, Jeffrey J., Ellis, Nathan A., Mouneimne, Ghassan, Georgieva, Teodora G., Lee, Yeon Sun, Vanderah, Todd W., Largent-Milnes, Tally, Mohler, Peter J., Hund, Thomas J., Langlais, Paul R., Mythreye, Karthikeyan, Lee, Nam Y.

“…Defective angiogenesis underlies over 50 malignant, ischemic and inflammatory disorders yet long-term therapeutic applications inevitably fail, thus…”
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The incidence of silicone oil-related visual loss following the removal of heavy silicone oil by Lee, J. Y. X., Sawant, R., Jonas, A., Lochhead, J.

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Late reopening of successfully treated macular holes after combined phaco‐vitrectomy ILM peel and gas by Ponomarenko, M., Lochhead, J.

“…Purpose To demonstrate reduction in reopening of macular holes after minimally invasive suturless vitrectomy and ILM peel combined with phaco compared with…”
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Unusual presentation of an intraocular foreign body with double – perforation and retention in lateral rectus muscle by Ponomarenko, M., Lochhead, J.

“…Purpose To report a rare complicated case of eye injury with endophthalmitis, an air bubble (bacteria‐produced), retinal detachment, and traumatic cataract,…”
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The incidence and distribution of iatrogenic retinal tears in 20-gauge and 23-gauge vitrectomy by Gosse, E, Newsom, R, Lochhead, J

“…Purpose The development of 23-gauge vitrectomy surgery has many benefits including a reduction in surgical time and faster postoperative rehabilitation;…”
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‘Double occlusion’: black Artisan iris claw intraocular lens insertion following failed occlusion treatment for intractable diplopia by Shonibare, O, Lochhead, J

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Occludin oligomeric assemblies at tight junctions of the blood–brain barrier are altered by hypoxia and reoxygenation stress by McCaffrey, Gwen, Willis, Colin L., Staatz, William D., Nametz, Nicole, Quigley, Carolyn A., Hom, Sharon, Lochhead, Jeffrey J., Davis, Thomas P.

“…Hypoxic (low oxygen) and reperfusion (post‐hypoxic reoxygenation) phases of stroke promote an increase in microvascular permeability at tight junctions (TJs)…”
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High-Dose Acetaminophen Alters the Integrity of the Blood-Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats by Yang, Junzhi, Betterton, Robert D, Williams, Erica I, Stanton, Joshua A, Reddell, Elizabeth S, Ogbonnaya, Chidinma E, Dorn, Emma, Davis, Thomas P, Lochhead, Jeffrey J, Ronaldson, Patrick T

“…The consumption of acetaminophen (APAP) can induce neurological changes in human subjects; however, effects of APAP on blood-brain barrier (BBB) integrity are…”
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