Search Results - "LO, Y. Y"
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Noninvasive Prenatal Diagnosis of Congenital Adrenal Hyperplasia Using Cell-Free Fetal DNA in Maternal Plasma
Published in The journal of clinical endocrinology and metabolism (01-06-2014)“…Context: Congenital adrenal hyperplasia (CAH) is an autosomal recessive condition that arises from mutations in CYP21A2 gene, which encodes for the…”
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2
Circulating biomarkers in the diagnosis and management of hepatocellular carcinoma
Published in Nature reviews. Gastroenterology & hepatology (01-10-2022)“…Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal causes of cancer-related death worldwide. The treatment of HCC remains challenging and…”
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3
Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies
Published in Science (American Association for the Advancement of Science) (09-04-2021)“…Liquid biopsies that analyze cell-free DNA in blood plasma are used for noninvasive prenatal testing, oncology, and monitoring of organ transplant recipients…”
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4
The Nexus of cfDNA and Nuclease Biology
Published in Trends in genetics (01-08-2021)“…Cell-free DNA (cfDNA) is a widely used noninvasive biomarker for diagnosis and prognosis of multiple disease states. Emerging evidence suggests that cfDNA…”
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5
Emission trading and carbon market performance in Shenzhen, China
Published in Applied energy (01-05-2017)“…•We assessed the market performance of Shenzhen’s emission trading scheme.•Trading records were used to estimate the degree of volatility and return…”
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The Long and Short of Circulating Cell-Free DNA and the Ins and Outs of Molecular Diagnostics
Published in Trends in genetics (01-06-2016)“…The discovery of cell-free tumor and fetal DNA molecules in the plasma of cancer patients and pregnant women, respectively, has opened up exciting…”
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7
Identification and characterization of extrachromosomal circular DNA in maternal plasma
Published in Proceedings of the National Academy of Sciences - PNAS (21-01-2020)“…We explored the presence of extrachromosomal circular DNA (eccDNA) in the plasma of pregnant women. Through sequencing following either restriction enzyme or…”
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8
Single-step deposition of high-mobility graphene at reduced temperatures
Published in Nature communications (18-03-2015)“…Current methods of chemical vapour deposition (CVD) of graphene on copper are complicated by multiple processing steps and by high temperatures required in…”
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9
Cell-free DNA for Colorectal Cancer Screening
Published in The New England journal of medicine (14-03-2024)“…This editorial describes the science behind a study of a noninvasive blood-based assay of cell-free DNA to screen for colorectal cancer in an average-risk…”
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10
Optimal heat stress metric for modelling heat-related mortality varies from country to country
Published in International journal of climatology (01-10-2023)“…Combined heat and humidity is frequently described as the main driver of human heat-related mortality, more so than dry-bulb temperature alone. While based on…”
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11
Repeated multi-qubit readout and feedback with a mixed-species trapped-ion register
Published in Nature (London) (01-11-2018)“…Quantum error correction is essential for realizing the full potential of large-scale quantum information processing devices 1 , 2 . Fundamental to its…”
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12
Diabetic Retinopathy: Pathophysiology and Treatments
Published in International journal of molecular sciences (20-06-2018)“…Diabetic retinopathy (DR) is the most common complication of diabetes mellitus (DM). It has long been recognized as a microvascular disease. The diagnosis of…”
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13
Quantum harmonic oscillator state synthesis by reservoir engineering
Published in Science (American Association for the Advancement of Science) (02-01-2015)“…The robust generation of quantum states in the presence of decoherence is a primary challenge for explorations of quantum mechanics at larger scales. Using the…”
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14
Enhanced cancer detection from cell-free DNA
Published in Nature biotechnology (01-04-2022)“…A new assay for cell-free DNA fragmentation improves prediction of gene expression in liquid biopsies…”
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15
Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing
Published in Proceedings of the National Academy of Sciences - PNAS (29-05-2018)“…Cell-free DNA in human plasma is nonrandomly fragmented and reflects genomewide nucleosomal organization. Previous studies had demonstrated tissue-specific…”
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16
Optimization of ultrasonic-assisted extraction of pomegranate (Punica granatum L.) seed oil
Published in Ultrasonics sonochemistry (01-01-2013)“…► Ultrasonic extraction gave the highest yield among the treatments investigated. ► Petroleum ether was the most practical and economical extraction solvent. ►…”
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17
Reconceptualizing green infrastructure for climate change adaptation: Barriers to adoption and drivers for uptake by spatial planners
Published in Landscape and urban planning (01-06-2015)“…•The paper defines the concept of green infrastructure within the context of climate adaptation.•Green infrastructure uptake is subject to biophysical and…”
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Discovery of Cell-Free Fetal DNA in Maternal Blood and Development of Noninvasive Prenatal Testing: 2022 Lasker-DeBakey Clinical Medical Research Award
Published in JAMA : the journal of the American Medical Association (04-10-2022)“…In this Viewpoint, 2022 Lasker-DeBakey Clinical Medical Research Award winner Y. M. Dennis Lo discusses his discovery and application of cell-free fetal DNA…”
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Microfluidics Digital PCR Reveals a Higher than Expected Fraction of Fetal DNA in Maternal Plasma
Published in Clinical chemistry (Baltimore, Md.) (01-10-2008)“…The precise measurement of cell-free fetal DNA in maternal plasma facilitates noninvasive prenatal diagnosis of fetal chromosomal aneuploidies and other…”
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Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients
Published in Proceedings of the National Academy of Sciences - PNAS (17-03-2015)“…Significance We used massively parallel sequencing to study the size profiles of plasma DNA samples at single-base resolution and in a genome-wide manner. We…”
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