Search Results - "LO, Y. M. Dennis"

Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing by Sun, Kun, Jiang, Peiyong, Wong, Ada I. C., Cheng, Yvonne K. Y., Cheng, Suk Hang, Zhang, Haiqiang, Chan, K. C. Allen, Leung, Tak Y., Chiu, Rossa W. K., Lo, Y. M. Dennis

“…Cell-free DNA in human plasma is nonrandomly fragmented and reflects genomewide nucleosomal organization. Previous studies had demonstrated tissue-specific…”
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Identification and characterization of extrachromosomal circular DNA in maternal plasma by Sin, Sarah T. K., Jiang, Peiyong, Deng, Jiaen, Ji, Lu, Cheng, Suk Hang, Dutta, Anindya, Leung, Tak Y., Chan, K. C. Allen, Chiu, Rossa W. K., Lo, Y. M. Dennis

“…We explored the presence of extrachromosomal circular DNA (eccDNA) in the plasma of pregnant women. Through sequencing following either restriction enzyme or…”
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Microfluidics Digital PCR Reveals a Higher than Expected Fraction of Fetal DNA in Maternal Plasma by Lun, Fiona M. F, Chiu, Rossa W. K, Allen Chan, K. C, Yeung Leung, Tak, Kin Lau, Tze, Dennis Lo, Y. M

“…The precise measurement of cell-free fetal DNA in maternal plasma facilitates noninvasive prenatal diagnosis of fetal chromosomal aneuploidies and other…”
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Detection and Characterization of Placental MicroRNAs in Maternal Plasma by Chim, Stephen S.C, Shing, Tristan K.F, Hung, Emily C.W, Leung, Tak-yeung, Lau, Tze-kin, Chiu, Rossa W.K, Dennis Lo, Y.M

“…The discovery of circulating fetal nucleic acids in maternal plasma has opened up new possibilities for noninvasive prenatal diagnosis. MicroRNAs (miRNAs), a…”
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Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin by Sun, Kun, Jiang, Peiyong, Cheng, Suk Hang, Cheng, Timothy H T, Wong, John, Wong, Vincent W S, Ng, Simon S M, Ma, Brigette B Y, Leung, Tak Y, Chan, Stephen L, Mok, Tony S K, Lai, Paul B S, Chan, Henry L Y, Sun, Hao, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis

“…Cell-free DNA (cfDNA) in human plasma is a class of biomarkers with many current and potential future diagnostic applications. Recent studies have shown that…”
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Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing by Chan, Rebecca W Y, Jiang, Peiyong, Peng, Xianlu, Tam, Lai-Shan, Liao, Gary J W, Li, Edmund K M, Wong, Priscilla C H, Sun, Hao, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis

“…We performed a high-resolution analysis of the biological characteristics of plasma DNA in systemic lupus erythematosus (SLE) patients using massively parallel…”
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High-resolution profiling of fetal DNA clearance from maternal plasma by massively parallel sequencing by Yu, Stephanie C Y, Lee, Shara W Y, Jiang, Peiyong, Leung, Tak Y, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis

“…With the advent of massively parallel sequencing (MPS), DNA analysis can now be performed in a genomewide manner. Recent studies have demonstrated the high…”
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Noninvasive prenatal methylomic analysis by genomewide bisulfite sequencing of maternal plasma DNA by Lun, Fiona M F, Chiu, Rossa W K, Sun, Kun, Leung, Tak Y, Jiang, Peiyong, Chan, K C Allen, Sun, Hao, Lo, Y M Dennis

“…Epigenetic mechanisms play an important role in prenatal development, but fetal tissues are not readily accessible. Fetal DNA molecules are present in maternal…”
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Methy-Pipe: an integrated bioinformatics pipeline for whole genome bisulfite sequencing data analysis by Jiang, Peiyong, Sun, Kun, Lun, Fiona M F, Guo, Andy M, Wang, Huating, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis, Sun, Hao

“…DNA methylation, one of the most important epigenetic modifications, plays a crucial role in various biological processes. The level of DNA methylation can be…”
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Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies by Lo, Y M Dennis, Han, Diana S C, Jiang, Peiyong, Chiu, Rossa W K

“…Liquid biopsies that analyze cell-free DNA in blood plasma are used for noninvasive prenatal testing, oncology, and monitoring of organ transplant recipients…”
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Noninvasive prenatal diagnosis of fetal trisomy 21 by allelic ratio analysis using targeted massively parallel sequencing of maternal plasma DNA by Liao, Gary J W, Chan, K C Allen, Jiang, Peiyong, Sun, Hao, Leung, Tak Y, Chiu, Rossa W K, Lo, Y M Dennis

“…Plasma DNA obtained from a pregnant woman contains a mixture of maternal and fetal DNA. The fetal DNA proportion in maternal plasma is relatively consistent as…”
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Noninvasive Prenatal Diagnosis of Fetal Chromosomal Aneuploidies by Maternal Plasma Nucleic Acid Analysis by Dennis Lo, Y. M, Chiu, Rossa W. K

“…The discovery of circulating cell-free fetal nucleic acids in maternal plasma has opened up new possibilities for noninvasive prenatal diagnosis. The potential…”
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Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA by Serpas, Lee, Chan, Rebecca W. Y., Jiang, Peiyong, Ni, Meng, Sun, Kun, Rashidfarrokhi, Ali, Soni, Chetna, Sisirak, Vanja, Lee, Wing-Shan, Cheng, Suk Hang, Peng, Wenlei, Chan, K. C. Allen, Chiu, Rossa W. K., Reizis, Boris, Lo, Y. M. Dennis

“…Circulating DNA in plasma consists of short DNA fragments. The biological processes generating such fragments are not well understood. DNASE1L3 is a secreted…”
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Enhanced cancer detection from cell-free DNA by Jiang, Peiyong, Lo, Y. M. Dennis

“…A new assay for cell-free DNA fragmentation improves prediction of gene expression in liquid biopsies…”
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Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients by Jiang, Peiyong, Chan, Carol W. M., Chan, K. C. Allen, Cheng, Suk Hang, Wong, John, Wong, Vincent Wai-Sun, Wong, Grace L. H., Chan, Stephen L., Mok, Tony S. K., Chan, Henry L. Y., Lai, Paul B. S., Chiu, Rossa W. K., Lo, Y. M. Dennis

“…Significance We used massively parallel sequencing to study the size profiles of plasma DNA samples at single-base resolution and in a genome-wide manner. We…”
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Genome-wide detection of cytosine methylation by single molecule real-time sequencing by Tse, O. Y. Olivia, Jiang, Peiyong, Cheng, Suk Hang, Peng, Wenlei, Shang, Huimin, Wong, John, Chan, Stephen L., Poon, Liona C. Y., Leung, Tak Y., Chan, K. C. Allen, Chiu, Rossa W. K., Lo, Y. M. Dennis

“…5-Methylcytosine (5mC) is an important type of epigenetic modification. Bisulfite sequencing (BS-seq) has limitations, such as severe DNA degradation. Using…”
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Cell-free DNA for Colorectal Cancer Screening by Lo, Y.M. Dennis

“…This editorial describes the science behind a study of a noninvasive blood-based assay of cell-free DNA to screen for colorectal cancer in an average-risk…”
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Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus by Lo, Y M Dennis, Chan, K C Allen, Sun, Hao, Chen, Eric Z, Jiang, Peiyong, Lun, Fiona M F, Zheng, Yama W, Leung, Tak Y, Lau, Tze K, Cantor, Charles R, Chiu, Rossa W K

“…Cell-free fetal DNA is present in the plasma of pregnant women. It consists of short DNA fragments among primarily maternally derived DNA fragments. We…”
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Screening of Fetal Chromosomal Aneuploidy by Noninvasive Prenatal Testing: From Innovation to Setting Public Health Agendas to Potential Impact on Other Fields by Dennis Lo, Y M

“…[...]it was an exciting development when my group and Stephen Quake's group at Stanford reported in 2007 that a single molecular counting approach such as…”
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Single-Molecule Sequencing Enables Long Cell-Free DNA Detection and Direct Methylation Analysis for Cancer Patients by Choy, L Y Lois, Peng, Wenlei, Jiang, Peiyong, Cheng, Suk Hang, Yu, Stephanie C Y, Shang, Huimin, Olivia Tse, O Y, Wong, John, Wong, Vincent Wai Sun, Wong, Grace L H, Lam, W K Jacky, Chan, Stephen L, Chiu, Rossa W K, Chan, K C Allen, Lo, Y M Dennis

“…Abstract Background Analysis of circulating tumor DNA has become increasingly important as a tool for cancer care. However, the focus of previous studies has…”
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