Search Results - "LLewelyn, Martin"

Transmission of Staphylococcus aureus between health-care workers, the environment, and patients in an intensive care unit: a longitudinal cohort study based on whole-genome sequencing by Price, James R, Dr, Cole, Kevin, BSc, Bexley, Andrew, PhD, Kostiou, Vasiliki, MSc, Eyre, David W, PhD, Golubchik, Tanya, PhD, Wilson, Daniel J, DPhil, Crook, Derrick W, Prof, Walker, A Sarah, Prof, Peto, Timothy E A, Prof, Llewelyn, Martin J, Prof, Paul, John, MD

“…Summary Background Health-care workers have been implicated in nosocomial outbreaks of Staphylococcus aureus , but the dearth of evidence from non-outbreak…”
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The antibiotic course has had its day by Llewelyn, Martin J, Fitzpatrick, Jennifer M, Darwin, Elizabeth, SarahTonkin-Crine, Gorton, Cliff, Paul, John, Peto, Tim E A, Yardley, Lucy, Hopkins, Susan, Walker, Ann Sarah

“…With little evidence that failing to complete a prescribed antibiotic course contributes to antibiotic resistance, it’s time for policy makers, educators, and…”
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Circulating Plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS) by Caserta, Stefano, Kern, Florian, Cohen, Jonathan, Drage, Stephen, Newbury, Sarah F., Llewelyn, Martin J.

“…Systemic inflammation in humans may be triggered by infection, termed sepsis, or non-infective processes, termed non-infective systemic inflammatory response…”
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What diagnostic strategies can help differentiate cellulitis from other causes of red legs in primary care? by Edwards, George, Freeman, Karoline, Llewelyn, Martin J, Hayward, Gail

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Duration of antibiotic treatment for common infections in English primary care: cross sectional analysis and comparison with guidelines by Pouwels, Koen B, Hopkins, Susan, Llewelyn, Martin J, Walker, Ann Sarah, McNulty, Cliodna Am, Robotham, Julie V

“…To evaluate the duration of prescriptions for antibiotic treatment for common infections in English primary care and to compare this with guideline…”
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Trends over time in Escherichia coli bloodstream infections, urinary tract infections, and antibiotic susceptibilities in Oxfordshire, UK, 1998–2016: a study of electronic health records by Vihta, Karina-Doris, Stoesser, Nicole, Llewelyn, Martin J, Quan, T Phuong, Davies, Tim, Fawcett, Nicola J, Dunn, Laura, Jeffery, Katie, Butler, Chris C, Hayward, Gail, Andersson, Monique, Morgan, Marcus, Oakley, Sarah, Mason, Amy, Hopkins, Susan, Wyllie, David H, Crook, Derrick W, Wilcox, Mark H, Johnson, Alan P, Peto, Tim E A, Walker, A Sarah

“…Escherichia coli bloodstream infections are increasing in the UK and internationally. The evidence base to guide interventions against this major public health…”
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Microbial diversity and antimicrobial resistance in faecal samples from acute medical patients assessed through metagenomic sequencing by Yokoyama, Maho, Peto, Leon, Budgell, Eric P, Jones, Nicola, Sheridan, Elizabeth, Liu, Jane, Walker, A Sarah, Stoesser, Nicole, Gweon, Hyun S, Llewelyn, Martin J

“…Antimicrobial resistance (AMR) is a threat to global public health. However, unsatisfactory approaches to directly measuring the AMR burden carried by…”
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Clinical management of Staphylococcus aureus bacteraemia by Thwaites, Guy E, Dr, Edgeworth, Jonathan D, PhD, Gkrania-Klotsas, Effrossyni, FRCP, Kirby, Andrew, MBChB, Tilley, Robert, MBChB, Török, M Estée, FRCP, Walker, Sarah, PhD, Wertheim, Heiman FL, PhD, Wilson, Peter, FRCPath, Llewelyn, Martin J, PhD

“…Summary Staphylococcus aureus bacteraemia is one of the most common serious bacterial infections worldwide. In the UK alone, around 12 500 cases each year are…”
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Endothelial and inflammatory pathophysiology in dengue shock: New insights from a prospective cohort study in Vietnam by McBride, Angela, Duyen, Huynh Thi Le, Vuong, Nguyen Lam, Tho, Phan Vinh, Tai, Luong Thi Hue, Phong, Nguyen Thanh, Ngoc, Nguyen Thanh, Yen, Lam Minh, Nhat, Phung Tran Huy, Vi, Tran Thuy, Llewelyn, Martin J, Thwaites, Louise, Hao, Nguyen Van, Yacoub, Sophie

“…Dengue shock (DS) is the most severe complication of dengue infection; endothelial hyperpermeability leads to profound plasma leakage, hypovolaemia and…”
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Co-infection in critically ill patients with COVID-19: an observational cohort study from England by Baskaran, Vadsala, Lawrence, Hannah, Lansbury, Louise E, Webb, Karmel, Safavi, Shahideh, Zainuddin, Nurul I, Huq, Tausif, Eggleston, Charlotte, Ellis, Jayne, Thakker, Clare, Charles, Bethan, Boyd, Sara, Williams, Tom, Phillips, Claire, Redmore, Ethan, Platt, Sarah, Hamilton, Eve, Barr, Andrew, Venyo, Lucy, Wilson, Peter, Bewick, Tom, Daniel, Priya, Dark, Paul, Jeans, Adam R, McCanny, Jamie, Edgeworth, Jonathan D, Llewelyn, Martin J, Schmid, Matthias L, McKeever, Tricia M, Beed, Martin, Lim, Wei Shen

“…During previous viral pandemics, reported co-infection rates and implicated pathogens have varied. In the 1918 influenza pandemic, a large proportion of severe…”
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Impact of recurrent Clostridium difficile infection: hospitalization and patient quality of life by Wilcox, Mark H, Ahir, Harblas, Coia, John E, Dodgson, Andrew, Hopkins, Susan, Llewelyn, Martin J, Settle, Chris, Mclain-Smith, Susan, Marcella, Stephen W

“…Data quantifying outcomes of recurrent Clostridium difficile infection (rCDI) are lacking. We sought to determine the UK hospital resource use and…”
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Superantigen-induced proliferation of human CD4+CD25- T cells is followed by a switch to a functional regulatory phenotype by Taylor, Amanda L, Llewelyn, Martin J

“…Bacterial superantigens are potent T cell activators. In humans they cause toxic shock and scarlet fever, and they are implicated in Kawasaki's disease,…”
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Accuracy of pancreatic stone protein for the diagnosis of infection in hospitalized adults: a systematic review and individual patient level meta-analysis by Prazak, Josef, Irincheeva, Irina, Llewelyn, Martin J., Stolz, Daiana, García de Guadiana Romualdo, Luis, Graf, Rolf, Reding, Theresia, Klein, Holger J., Eggimann, Philippe, Que, Yok-Ai

“…Background Accurate biomarkers to diagnose infection are lacking. Studies reported good performance of pancreatic stone protein (PSP) to detect infection. The…”
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Severity of Systemic Inflammatory Response Syndrome Affects the Blood Levels of Circulating Inflammatory-Relevant MicroRNAs by Caserta, Stefano, Mengozzi, Manuela, Kern, Florian, Newbury, Sarah F, Ghezzi, Pietro, Llewelyn, Martin J

“…The systemic inflammatory response syndrome (SIRS) is a potentially lethal response triggered by diverse forms of tissue injury and infection. When systemic…”
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Selective culture enrichment and sequencing of feces to enhance detection of antimicrobial resistance genes in third-generation cephalosporin resistant Enterobacteriaceae by Peto, Leon, Fawcett, Nicola J, Crook, Derrick W, Peto, Tim E A, Llewelyn, Martin J, Walker, A Sarah

“…Metagenomic sequencing of fecal DNA can usefully characterise an individual's intestinal resistome but is limited by its inability to detect important…”
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Appraising research policy instrument mixes: a multicriteria mapping study in six European countries of diagnostic innovation to manage antimicrobial resistance by Coburn, Josie, Bone, Frederique, Hopkins, Michael M., Stirling, Andy, Mestre-Ferrandiz, Jorge, Arapostathis, Stathis, Llewelyn, Martin J.

“…•The following contributions are provided: A general process for conducting systematic prospective appraisal of policy options within the field of research…”
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Staphylococcus aureus bloodstream infection: A pooled analysis of five prospective, observational studies by Kaasch, Achim J, Barlow, Gavin, Edgeworth, Jonathan D, Fowler, Vance G, Hellmich, Martin, Hopkins, Susan, Kern, Winfried V, Llewelyn, Martin J, Rieg, Siegbert, Rodriguez-Baño, Jesús, Scarborough, Matthew, Seifert, Harald, Soriano, Alex, Tilley, Robert, Tőrők, M. Estée, Weiß, Verena, Wilson, A.Peter R, Thwaites, Guy E

“…Summary Objectives Staphylococcus aureus bacteraemia is a common, often fatal infection. Our aim was to describe how its clinical presentation varies between…”
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Mortality risks associated with emergency admissions during weekends and public holidays: an analysis of electronic health records by Walker, A Sarah, Prof, Mason, Amy, DPhil, Quan, T Phuong, MSc, Fawcett, Nicola J, MBChB, Watkinson, Peter, MD, Llewelyn, Martin, Prof, Stoesser, Nicole, DPhil, Finney, John, MSc, Davies, Jim, Prof, Wyllie, David H, DPhil, Crook, Derrick W, Prof, Peto, Tim E A, Prof

“…Summary Background Weekend hospital admission is associated with increased mortality, but the contributions of varying illness severity and admission time to…”
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Sepsis biomarkers in unselected patients on admission to intensive or high-dependency care by Llewelyn, Martin J, Berger, Mario, Gregory, Mark, Ramaiah, Ravi, Taylor, Amanda L, Curdt, Ingo, Lajaunias, Frédéric, Graf, Rolf, Blincko, Stuart J, Drage, Stephen, Cohen, Jonathan

“…Although many sepsis biomarkers have shown promise in selected patient groups, only C-reactive protein and procalcitonin (PCT) have entered clinical practice…”
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Antibiotic policies in acute English NHS trusts: implementation of 'Start Smart-Then Focus' and relationship with Clostridium difficile infection rates by Llewelyn, Martin J, Hand, Kieran, Hopkins, Susan, Walker, A Sarah

“…The objective of this study was to establish how antibiotic prescribing policies at National Health Service (NHS) hospitals match the England Department of…”
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