Search Results - "LIVI, Carolina B"

L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer by Shim, Eun-Hee, Livi, Carolina B, Rakheja, Dinesh, Tan, Jubilee, Benson, Daniel, Parekh, Vishwas, Kho, Eun-Young, Ghosh, Arindam P, Kirkman, Richard, Velu, Sadanan, Dutta, Shilpa, Chenna, Balachandra, Rea, Shane L, Mishur, Robert J, Li, Qiuhua, Johnson-Pais, Teresa L, Guo, Lining, Bae, Sejong, Wei, Shi, Block, Karen, Sudarshan, Sunil

“…Through unbiased metabolomics, we identified elevations of the metabolite 2-hydroxyglutarate (2HG) in renal cell carcinoma (RCC). 2HG can inhibit…”
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Integrative Epigenetic and Gene Expression Analysis of Renal Tumor Progression to Metastasis by Nam, Hye-Young, Chandrashekar, Darshan S, Kundu, Anirban, Shelar, Sandeep, Kho, Eun-Young, Sonpavde, Guru, Naik, Gurudatta, Ghatalia, Pooja, Livi, Carolina B, Varambally, Sooryanarayana, Sudarshan, Sunil

“…The Cancer Genome Atlas (TCGA) and other large-scale genomic data pipelines have been integral to the current understanding of the molecular events underlying…”
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Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function by Kleensang, Andre, Vantangoli, Marguerite M., Odwin-DaCosta, Shelly, Andersen, Melvin E., Boekelheide, Kim, Bouhifd, Mounir, Fornace, Albert J., Li, Heng-Hong, Livi, Carolina B., Madnick, Samantha, Maertens, Alexandra, Rosenberg, Michael, Yager, James D., Zhao, Liang, Hartung, Thomas

“…Common recommendations for cell line authentication, annotation and quality control fall short addressing genetic heterogeneity. Within the Human Toxome…”
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B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses by Lin, Pei-Yi, Sun, Lishi, Thibodeaux, Suzanne R, Ludwig, Sara M, Vadlamudi, Ratna K, Hurez, Vincent J, Bahar, Rumana, Kious, Mark J, Livi, Carolina B, Wall, Shawna R, Chen, Lieping, Zhang, Bin, Shin, Tahiro, Curiel, Tyler J

“…CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) are immunopathogenic in cancers by impeding tumor-specific immunity. B7-homologue 1 (B7-H1) (CD274) is a…”
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Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice by HUREZ, Vincent, DANIEL, Benjamin J, WALL, Shawna, BRUMLIK, Michael J, SHIN, Tahiro, BIN ZHANG, CURIEL, Tyler J, LISHI SUN, LIU, Ai-Jie, LUDWIG, Sara M, KIOUS, Mark J, THIBODEAUX, Suzanne R, PANDESWARA, Srilakshmi, MURTHY, Kruthi, LIVI, Carolina B

“…Although cancer tends to affect the elderly, most preclinical studies are carried out in young subjects. In this study, we developed a melanoma-specific cancer…”
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Adipose Tissue-Secreted Factors Alter Bladder Cancer Cell Migration by Johnson-Pais, Teresa, Kaushik, Dharam, Wilson, Desiree, Livi, Carolina B., Svatek, Robert S., Ashcraft, Keith A., Hariharan, Nisha, Leach, Robin J.

“…Background. Obesity is associated with an increased risk of bladder cancer recurrence. This study investigated the role of adipose tissue in bladder cancer…”
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Analysis of prostate-specific antigen transcripts in chimpanzees, cynomolgus monkeys, baboons, and African green monkeys by Mubiru, James N, Yang, Alice S, Olsen, Christian, Nayak, Sudhir, Livi, Carolina B, Dick, Jr, Edward J, Owston, Michael, Garcia-Forey, Magdalena, Shade, Robert E, Rogers, Jeffrey

“…The function of prostate-specific antigen (PSA) is to liquefy the semen coagulum so that the released sperm can fuse with the ovum. Fifteen spliced variants of…”
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Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion by Sudarshan, Sunil, Shanmugasundaram, Karthigayan, Naylor, Susan L, Lin, Shu, Livi, Carolina B, O'Neill, Christine F, Parekh, Dipen J, Yeh, I-Tien, Sun, Lu-Zhe, Block, Karen

“…Germline mutations of FH, the gene that encodes for the tricarboxylic acid TCA (TCA) cycle enzyme fumarate hydratase, are associated with an inherited form of…”
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The Human Toxome Collaboratorium: A Shared Environment for Multi-Omic Computational Collaboration within a Consortium by Fasani, Rick A, Livi, Carolina B, Choudhury, Dipanwita R, Kleensang, Andre, Bouhifd, Mounir, Pendse, Salil N, McMullen, Patrick D, Andersen, Melvin E, Hartung, Thomas, Rosenberg, Michael

“…The Human Toxome Project is part of a long-term vision to modernize toxicity testing for the 21st century. In the initial phase of the project, a consortium of…”
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The Oncometabolite Fumarate Promotes Pseudohypoxia Through Noncanonical Activation of NF-κB Signaling by Shanmugasundaram, Karthigayan, Nayak, Bijaya, Shim, Eun-Hee, Livi, Carolina B., Block, Karen, Sudarshan, Sunil

“…Inactivating mutations of the gene encoding the tricarboxylic acid cycle enzyme fumarate hydratase (FH) have been linked to an aggressive variant of hereditary…”
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PRDM16 suppresses HIF-targeted gene expression in kidney cancer by Kundu, Anirban, Nam, Hyeyoung, Shelar, Sandeep, Chandrashekar, Darshan S, Brinkley, Garrett, Karki, Suman, Mitchell, Tanecia, Livi, Carolina B, Buckhaults, Phillip, Kirkman, Richard, Tang, Yawen, Rowe, Glenn C, Wei, Shi, Varambally, Sooryanarayana, Sudarshan, Sunil

“…Analysis of transcriptomic data demonstrates extensive epigenetic gene silencing of the transcription factor PRDM16 in renal cancer. We show that restoration…”
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Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs by Calhoun, Cheresa, Shivshankar, Pooja, Saker, Mirna, Sloane, Lauren B, Livi, Carolina B, Sharp, Zelton D, Orihuela, Carlos J, Adnot, Serge, White, Eric S, Richardson, Arlan, Le Saux, Claude Jourdan

“…Age-associated decline in organ function governs life span. We determined the effect of aging on lung function and cellular/molecular changes of 8- to 32-month…”
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Recovery of Developmentally Defined Gene Sets from High-Density cDNA Macroarrays by Rast, Jonathan P, Amore, Gabriele, Calestani, Cristina, Livi, Carolina B, Ransick, Andrew, Davidson, Eric H

“…New technologies for isolating differentially expressed genes from large arrayed cDNA libraries are reported. These methods can be used to identify genes that…”
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Regulation of spblimp1/krox1a, an alternatively transcribed isoform expressed in midgut and hindgut of the sea urchin gastrula by Livi, Carolina B., Davidson, Eric H.

“…The sea urchin regulatory gene Spblimp1/krox produces alternatively transcribed and spliced isoforms, 1a and 1b, which have different temporal and spatial…”
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Over-represented sequences located on 3' UTRs are potentially involved in regulatory functions by Yoon, Kihoon, Ko, Daijin, Doderer, Mark, Livi, Carolina B., Penalva, Luiz O.F.

“…Eukaryotic gene expression must be coordinated for the proper functioning of biological processes. This coordination can be achieved both at the…”
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HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy by Thattaliyath, Bijoy D, Livi, Carolina B, Steinhelper, Mark E, Toney, Glenn M, Firulli, Anthony B

“…The HAND basic Helix-Loop-Helix (bHLH) transcription factors are essential for normal cardiac and extraembryonic development. Although highly evolutionarily…”
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Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors by Livi, Carolina B, Hardman, Rulon L, Christy, Barbara A, Dodds, Sherry G, Jones, Diane, Williams, Charnae, Strong, Randy, Bokov, Alex, Javors, Martin A, Ikeno, Yuji, Hubbard, Gene, Hasty, Paul, Sharp, Zelton Dave

“…Chronic treatment of mice with an enterically released formulation of rapamycin (eRapa) extends median and maximum life span, partly by attenuating cancer. The…”
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eRapa Restores a Normal Life Span in a FAP Mouse Model by HASTY, Paul, LIVI, Carolina B, LISHI SUN, HUREZ, Vincent, CURIEL, Tyler J, ZELTON DAVE SHARP, DODDS, Sherry G, JONES, Diane, STRONG, Randy, JAVORS, Martin, FISCHER, Kathleen E, SLOANE, Lauren, MURTHY, Kruthi, HUBBARD, Gene

“…Mutation of a single copy of the adenomatous polyposis coli (APC) gene results in familial adenomatous polyposis (FAP), which confers an extremely high risk…”
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Abstract 3047: Sensitization of prostate cancer to chemo-radiation by ribosomal protein S6 inhibition by Hussain, Suleman S., Livi, Carolina B., Papanikolaou, Nikos, Chan, Daniel C., Ghosh, Rita, Kumar, Addanki P.

“…Abstract Radiation Therapy (RT) is curative for most localized prostate cancer (PCA) patients, but is limited by dose-related toxicities and radioresistance…”
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Rapamycin Prevents Surgery-Induced Immune Dysfunction in Patients with Bladder Cancer by Svatek, Robert S, Ji, Niannian, de Leon, Essel, Mukherjee, Neelam Z, Kabra, Aashish, Hurez, Vincent, Nicolas, Marlo, Michalek, Joel E, Javors, Martin, Wheeler, Karen, Sharp, Z Dave, Livi, Carolina B, Shu, Zhen-Ju, Henkes, David, Curiel, Tyler J

“…The mechanistic target of rapamycin (mTOR) integrates environmental inputs to regulate cellular growth and metabolism in tumors. However, mTOR also regulates…”
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