Search Results - "LIVERSIDGE, G. G"

Nanosizing for oral and parenteral drug delivery: A perspective on formulating poorly-water soluble compounds using wet media milling technology by Merisko-Liversidge, Elaine, Liversidge, Gary G.

“…A significant percentage of active pharmaceutical ingredients identified through discovery screening programs is poorly soluble in water. These molecules are…”
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Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds by Merisko-Liversidge, Elaine M., Liversidge, Gary G.

“…More than 40% of compounds identified through combinatorial screening programs are poorly soluble in water. These molecules are difficult to formulate using…”
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Nanosizing: a formulation approach for poorly-water-soluble compounds by Merisko-Liversidge, Elaine, Liversidge, Gary G, Cooper, Eugene R

“…Poorly-water-soluble compounds are difficult to develop as drug products using conventional formulation techniques and are frequently abandoned early in…”
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Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs by Jinno, Jun-ichi, Kamada, Naoki, Miyake, Masateru, Yamada, Keigo, Mukai, Tadashi, Odomi, Masaaki, Toguchi, Hajime, Liversidge, Gary G., Higaki, Kazutaka, Kimura, Toshikiro

“…The purpose of the present study was to investigate the effects of particle size on the dissolution and oral absorption of cilostazol. Three types of…”
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Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs by Liversidge, Gary G., Cundy, Kenneth C.

“…Danazol is a poorly water soluble compound (10 μg/ml) that demonstrates poor bioavailability. The impact on bioavailability of increasing the area for…”
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In vitro–in vivo correlation for wet-milled tablet of poorly water-soluble cilostazol by Jinno, Jun-ichi, Kamada, Naoki, Miyake, Masateru, Yamada, Keigo, Mukai, Tadashi, Odomi, Masaaki, Toguchi, Hajime, Liversidge, Gary G., Higaki, Kazutaka, Kimura, Toshikiro

“…The purpose of the present study was to investigate oral bioavailability of an immediate release tablet containing wet-milled crystals of a poorly…”
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Drug particle size reduction for decreasing gastric irritancy and enhancing absorption of naproxen in rats by Liversidge, Gary G., Conzentino, Phil

“…Gastric mucosal damage, the most common event following oral administration of NSAIDs, is due to a combination of a systemic effect and a high local drug…”
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Formulation and antitumor activity evaluation of nanocrystalline suspensions of poorly soluble anticancer drugs by MERISKO-LIVERSIDGE, E, SARPOTDAR, P, JONES, J, CORBETT, T, COOPER, E, LIVERSIDGE, G. G, BRUNO, J, HAJII, S, WEI, L, PELTIER, N, RAKE, J, SHAW, J. M, PUGH, S, POLIN, L

“…Determine if wet milling technology could be used to formulate water insoluble antitumor agents as stabilized nanocrystalline drug suspensions that retain…”
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Insulin nanoparticles: a novel formulation approach for poorly water soluble Zn-insulin by Merisko-Liversidge, Elaine, McGurk, Simon L, Liversidge, Gary G

“…To determine the feasibility of using wet milling technology to formulate poorly water soluble zinc-insulin as a stable, biologically active, nanoparticulate…”
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A formulation strategy for gamma secretase inhibitor ELND006, a BCS class II compound: development of a nanosuspension formulation with improved oral bioavailability and reduced food effects in dogs by Quinn, Kevin, Gullapalli, Rampurna Prasad, Merisko-Liversidge, Elaine, Goldbach, Erich, Wong, Angelina, Liversidge, Gary G, Hoffman, Wherly, Sauer, John-Michael, Bullock, John, Tonn, George

“…ELND006 is a novel gamma secretase inhibitor previously under investigation for the oral treatment of Alzheimer's disease. ELND006 shows poor solubility and…”
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Model optimization via "Lateral validation", for purposes of clinical trial simulation by Gobburu, J.V.S., Holford, N.H.G., Ko, H.C., Peck, C.C., Liversidge, G.G.

“…Clinical Pharmacology & Therapeutics (1999) 65, 164–164; doi:…”
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The electrophoretic mobility of tripeptides as a function of pH and ionic strength : comparison with iontophoretic flux data by VANORMAN HUFF, B, LIVERSIDGE, G. G, MCINTIRE, G. L

“…Capillary electrophoresis (CE) is an extremely efficient separations tool which can also be used to determine fundamental molecular parameters, e.g., the…”
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Rectal route of administration for peptides by Liversidge, G G

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Determination of allopurinol and oxypurinol in rat plasma, intestinal wash, and bile by high-performance liquid chromatography with electrochemical detection (HPLC/EC) following automated solid phase extraction by EISENBERG, E. J, CONZENTINO, P, LIVERSIDGE, G. G, CUNDY, K. C

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Influence of indomethacin amphoteric gel on gastric ulcerogenicity and absorption of indomethacin in rats by LIVERSIDGE, G. G, DENT, J, MARK EICKHOFF, W

“…Indomethacin is a potent and efficacious antiinflammatory agent. However, a limiting side effect is its ability to cause gastric ulceration. This study was…”
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Nasal delivery of a vasopressin antagonist in dogs by Liversidge, G G, Wilson, C G, Sternson, W L, Kinter, L B

“…The dosage form (drop or spray) and site of administration (dorsal or ventral surface of the nostril) profoundly affect the distribution and clearance of a…”
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Liquid chromatographic analysis of a potential polymeric-pendant drug delivery system for peptides. Application of high-performance size-exclusion chromatography, reversed-phase high-performance liquid chromatography and ion chromatography to the evaluation of biodegradable poly[(chloromethoxytrialanine methyl ester)phosphazenes] by Eickhoff, W M, Liversidge, G G, Mutharasan, R

“…A novel water-soluble polymer, poly[(chloromethoxytrialanine methyl ester)phosphazene] (poly-Tame), was characterized and evaluated using high-performance…”
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Simultaneous analysis of 1-beta-D-arabinofuranosylcytosine, 1-beta-D-arabinofuranosyluracil and sodium salicylate in biological samples by high-performance liquid chromatography by Liversidge, G G, Nishihata, T, Higuchi, T, Shaffer, R, Cortese, M

“…A reversed-phase high-performance liquid chromatographic column switching system is described for the rapid and complete separation of…”
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Enhanced serum concentrations of Ara-C using suppositories containing tetrahydrouridine as a deamination inhibitor of Ara-C by Liversidge, G G, Nishihata, T, Engle, K K, Higuchi, T

“…Rectal bioavailability of Ara-C (serum AUC 4 h: 65 micrograms h-1 ml-1) administered in a suppository formulation containing tetrahydrouridine (a deamination…”
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Nanosizing for oral and parenteral drug delivery: A perspective on formulating poorly-water soluble compounds using wet media milling technology: NANODRUG PARTICLES AND NANOFORMULATIONS FOR DRUG DELIVERY by MERISKO-LIVERSIDGE, Elaine, LIVERSIDGE, Gary G

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