Search Results - "LIUSONG YIN"

Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions by Yin, Liusong, Maben, Zachary J, Becerra, Aniuska, Stern, Lawrence J

“…Ag presentation by MHC class II (MHC II) molecules to CD4(+) T cells plays a key role in the regulation of the adaptive immune response. Loading of antigenic…”
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Human CD4+ T Cell Response to Human Herpesvirus 6 by NASTKE, Maria-D, BECERRA, Aniuska, LIUSONG YIN, DOMINGUEZ-AMOROCHO, Omar, GIBSON, Laura, STERN, Lawrence J, CALVO-CALLE, J. Mauricio

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Human CD4+ T Cell Epitope in the Influenza Hemagglutinin Is Cross-Reactive to Influenza A Virus Subtypes and to Influenza B Virus by BABON, Jenny Aurielle B, CRUZ, John, ENNIS, Francis A, LIUSONG YIN, TERAJIMA, Masanori

“…Author's Correction ( vol. 87 , p. 9396 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling by Vicini, Paolo, Tiwari, Abhinav, Chen, Xiaoying, Yin, Liusong, Hickling, Timothy P.

“…Therapeutic protein products (TPP) have been widely used to treat a variety of human diseases, including cancer, hemophilia, and autoimmune diseases. However,…”
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An unstable Th epitope of P. falciparum fosters central memory T cells and anti-CS antibody responses by Parra-López, Carlos A, Bernal-Estévez, David, Yin, Liusong, Vargas, Luis Eduardo, Pulido-Calixto, Carolina, Salazar, Luz Mary, Calvo-Calle, J Mauricio, Stern, Lawrence J

“…Malaria is transmitted by Plasmodium-infected anopheles mosquitoes. Widespread resistance of mosquitoes to insecticides and resistance of parasites to drugs…”
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A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC50 determination by Yin, Liusong, Stern, Lawrence J.

“…HLA-DM (DM) functions as a peptide editor that mediates the exchange of peptides loaded onto MHCII molecules by accelerating peptide dissociation and…”
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Therapeutic outcomes, assessments, risk factors and mitigation efforts of immunogenicity of therapeutic protein products by Yin, Liusong, Chen, Xiaoying, Vicini, Paolo, Rup, Bonita, Hickling, Timothy P.

“…•We review therapeutic protein immunogenicity and its impact on efficacy and safety.•Patient- and product-related risk factors for immunogenicity are…”
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Abstract 5549: First-in-class TNFR2 agonist & antagonist antibodies as Treg-Teff modulator for cancer immunotherapy by Jiang, Xiaoling, Wu, Chonging, Yin, Liusong

“…Abstract Tumor necrosis factor receptor 2 (TNFR2) is expressed on highly suppressive tumor-infiltrating T regulatory cells (Treg), activated T effector cells…”
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Abstract 5307: Preclinical evaluation of a potential FIC 4-1BB/CD24 bispecific antibody IBD0333 by Jiang, Xiaoling, Wu, Chongbing, Chen, Zi, Yin, Liusong

“…Abstract Background: This study demonstrates the preclinical evaluation of a novel 4-1BB/CD24 bispecific antibody IBD0333. 4-1BB’s activation triggers a…”
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Abstract 4080: IBB0979, A novel B7H3/IL-10 immunocytokine of monovalent anti-B7H3 antibody fused with IL-10 homodimer by Jiang, Xiaoling, Wu, Chongbing, Chen, Zi, Yin, Liusong

“…Abstract Background: This study demonstrates the preclinical evaluation of a novel B7H3/IL-10 immunocytokine IBB0979. IBB0979 was designed to solve the…”
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A NOVEL B7H3/NKP30 BISPECIFIC NK CELL ENGAGER FOR CANCER IMMUNOTHERAPY by Jiang, Xiaoling, Wu, Chongbing, Chen, Zi, Yin, Liusong

“…Abstract Background and Significance Biological therapies harnessing the adaptive immune system have achieved a great success, given the clinical efficacy of…”
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Abstract 1889: IAP0971, A novel PD1/IL15 immunocytokine that binds specifically to PD1 and fuses IL15/IL15Rα complex by Yin, Liusong, Jiang, Xiaoling, Wu, Chongbing, Chen, Zi

“…Abstract Immunotherapy has gained great breakthroughs since the 21st century, which however has limitations of relatively low objective response rate, short…”
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Abstract 1888: IAE0972, A novel EGFR/IL10 immunocytokine of monovalent anti-EGFR antibody fused with IL10 homodimer by Yin, Liusong, Jiang, Xiaoling, Wu, Chongbing, Chen, Zi

“…Abstract Exhaustion of immune cells in the tumor microenvironment has been found and confirmed in many tumor cases, accounting for the major problems of…”
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The Dendritic Cell Major Histocompatibility Complex II (MHC II) Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM Sensitivity by Clement, Cristina C., Becerra, Aniuska, Yin, Liusong, Zolla, Valerio, Huang, Liling, Merlin, Simone, Follenzi, Antonia, Shaffer, Scott A., Stern, Lawrence J., Santambrogio, Laura

“…The repertoire of peptides displayed in vivo by MHC II molecules derives from a wide spectrum of proteins produced by different cell types. Although…”
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Preclinical evaluation of IAP0971, a novel immunocytokine that binds specifically to PD1 and fuses IL15/IL15Rα complex by Chen, Jihong, Shen, Ziyou, Jiang, Xiaoling, Huang, Zhenzhen, Wu, Chongbing, Jiang, Dongcheng, Yin, Liusong

“…Abstract Background Currently, cytokine therapy for cancer has demonstrated efficacy in certain diseases but is generally accompanied by severe toxicity. The…”
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Evaluating the role of HLA-DM in MHC II-peptide association reactions1 by Yin, Liusong, Maben, Zachary, Becerra, Aniuska, Stern, Lawrence J.

“…Antigen presentation by major histocompatibility complex class II molecules (MHC II) to CD4+ T cells plays a key role in the regulation of the adaptive immune…”
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MHC II-peptide complex conformation constrained by interactions throughout the peptide binding groove determines HLA-DM susceptibility (P5014) by Yin, Liusong, Trenh, Peter, Stern, Lawrence

“…Abstract HLA-DM (DM) mediates the exchange of peptides loaded onto MHC II. However, the determinants of DM-mediated peptide release remain unclear and…”
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Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide–MHC complexes by Hellman, Lance M., Yin, Liusong, Wang, Yuan, Blevins, Sydney J., Riley, Timothy P., Belden, Orrin S., Spear, Timothy T., Nishimura, Michael I., Stern, Lawrence J., Baker, Brian M.

“…Measurements of thermal stability by circular dichroism (CD) spectroscopy have been widely used to assess the binding of peptides to MHC proteins, particularly…”
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HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-lives by Yin, Liusong, Calvo-Calle, J Mauricio, Dominguez-Amorocho, Omar, Stern, Lawrence J

“…HLA-DM (DM) is a nonclassical MHC class II (MHC II) protein that acts as a peptide editor to mediate the exchange of peptides loaded onto MHC II during Ag…”
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Measurement of Peptide Binding to MHC Class II Molecules by Fluorescence Polarization by Yin, Liusong, Stern, Lawrence J

“…Peptide binding to major histocompatibility complex class II (MHCII) molecules is a key process in antigen presentation and CD4+ T cell epitope selection. This…”
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