Search Results - "LIU PENTAO"

SpatialDM for rapid identification of spatially co-expressed ligand–receptor and revealing cell–cell communication patterns by Li, Zhuoxuan, Wang, Tianjie, Liu, Pentao, Huang, Yuanhua

“…Cell-cell communication is a key aspect of dissecting the complex cellular microenvironment. Existing single-cell and spatial transcriptomics-based methods…”
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Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers by Gao, Xuefei, Tsang, Jason C H, Gaba, Fortis, Wu, Donghai, Lu, Liming, Liu, Pentao

“…The transcription activator-like effectors (TALEs) and the RNA-guided clustered regularly interspaced short palindromic repeat (CRISPR) associated protein…”
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Establishment of porcine and human expanded potential stem cells by Gao, Xuefei, Nowak-Imialek, Monika, Chen, Xi, Chen, Dongsheng, Herrmann, Doris, Ruan, Degong, Chen, Andy Chun Hang, Eckersley-Maslin, Melanie A., Ahmad, Shakil, Lee, Yin Lau, Kobayashi, Toshihiro, Ryan, David, Zhong, Jixing, Zhu, Jiacheng, Wu, Jian, Lan, Guocheng, Petkov, Stoyan, Yang, Jian, Antunes, Liliana, Campos, Lia S., Fu, Beiyuan, Wang, Shengpeng, Yong, Yu, Wang, Xiaomin, Xue, Song-Guo, Ge, Liangpeng, Liu, Zuohua, Huang, Yong, Nie, Tao, Li, Peng, Wu, Donghai, Pei, Duanqing, Zhang, Yi, Lu, Liming, Yang, Fengtang, Kimber, Susan J., Reik, Wolf, Zou, Xiangang, Shang, Zhouchun, Lai, Liangxue, Surani, Azim, Tam, Patrick P. L., Ahmed, Asif, Yeung, William Shu Biu, Teichmann, Sarah A., Niemann, Heiner, Liu, Pentao

“…We recently derived mouse expanded potential stem cells (EPSCs) from individual blastomeres by inhibiting the critical molecular pathways that predispose their…”
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piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells by Woltjen, Knut, Michael, Iacovos P., Mohseni, Paria, Desai, Ridham, Mileikovsky, Maria, Hämäläinen, Riikka, Cowling, Rebecca, Wang, Wei, Liu, Pentao, Gertsenstein, Marina, Kaji, Keisuke, Sung, Hoon-Ki, Nagy, Andras

“…Virus-free iPS cells The discovery that non-germline adult cells can be reprogrammed to become pluripotent, able to differentiate into any cell type, opened up…”
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Bcl11b, a novel GATA3-interacting protein, suppresses Th1 while limiting Th2 cell differentiation by Fang, Difeng, Cui, Kairong, Hu, Gangqing, Gurram, Rama Krishna, Zhong, Chao, Oler, Andrew J, Yagi, Ryoji, Zhao, Ming, Sharma, Suveena, Liu, Pentao, Sun, Bing, Zhao, Keji, Zhu, Jinfang

“…GATA-binding protein 3 (GATA3) acts as the master transcription factor for type 2 T helper (Th2) cell differentiation and function. However, it is still…”
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The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals by Zhang, Nailing, Bai, Haibo, David, Karen K., Dong, Jixin, Zheng, Yonggang, Cai, Jing, Giovannini, Marco, Liu, Pentao, Anders, Robert A., Pan, Duojia

“…The conserved Hippo signaling pathway regulates organ size in Drosophila and mammals. While a core kinase cascade leading from the protein kinase Hippo (Hpo)…”
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Myeloid-derived suppressor cells promote lung cancer metastasis by CCL11 to activate ERK and AKT signaling and induce epithelial-mesenchymal transition in tumor cells by Lin, Shouheng, Zhang, Xuchao, Huang, Guohua, Cheng, Lin, Lv, Jiang, Zheng, Diwei, Lin, Simiao, Wang, Suna, Wu, Qiting, Long, Youguo, Li, Baiheng, Wei, Wei, Liu, Pentao, Pei, Duanqing, Li, Yangqiu, Wen, Zhesheng, Cui, Shuzhong, Li, Peng, Sun, Xiaofang, Wu, Yilong, Yao, Yao

“…Myeloid-derived suppressor cells (MDSCs) suppress antitumor immune activities and facilitate cancer progression. Although the concept of immunosuppressive…”
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Bcl11b is essential for group 2 innate lymphoid cell development by Walker, Jennifer A, Oliphant, Christopher J, Englezakis, Alexandros, Yu, Yong, Clare, Simon, Rodewald, Hans-Reimer, Belz, Gabrielle, Liu, Pentao, Fallon, Padraic G, McKenzie, Andrew N J

“…Group 2 innate lymphoid cells (ILC2s) are often found associated with mucosal surfaces where they contribute to protective immunity, inappropriate allergic…”
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Chromosomal transposition of PiggyBac in mouse embryonic stem cells by Wang, Wei, Lin, Chengyi, Lu, Dong, Ning, Zeming, Cox, Tony, Melvin, David, Wang, Xiaozhong, Bradley, Allan, Liu, Pentao

“…Transposon systems are widely used for generating mutations in various model organisms. PiggyBac (PB) has recently been shown to transpose efficiently in the…”
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Bcl11a is essential for lymphoid development and negatively regulates p53 by Yu, Yong, Wang, Juexuan, Khaled, Walid, Burke, Shannon, Li, Peng, Chen, Xiongfeng, Yang, Wei, Jenkins, Nancy A, Copeland, Neal G, Zhang, Shujun, Liu, Pentao

“…Transcription factors play important roles in lymphopoiesis. We have previously demonstrated that Bcl11a is essential for normal lymphocyte development in the…”
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Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1 by Wang, Wei, Yang, Jian, Liu, Hui, Lu, Dong, Chen, Xiongfeng, Zenonos, Zenon, Campos, Lia S, Rad, Roland, Guo, Ge, Zhang, Shujun, Bradley, Allan, Liu, Pentao

“…Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by expressing four transcription factors: Oct4, Sox2, Klf4, and c-Myc. Here we…”
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Establishment of bovine expanded potential stem cells by Zhao, Lixia, Gao, Xuefei, Zheng, Yuxuan, Wang, Zixin, Zhao, Gaoping, Ren, Jie, Zhang, Jia, Wu, Jian, Wu, Baojiang, Chen, Yanglin, Sun, Wei, Li, Yunxia, Su, Jie, Ding, Yulin, Gao, Yuan, Liu, Moning, Bai, Xiaochun, Sun, Liangzhong, Cao, Guifang, Tang, Fuchou, Bao, Siqin, Liu, Pentao, Li, Xihe

“…Embryonic stem cells (ESCs) and induced pluripotent stem cells have the potential to differentiate to all cell types of an adult individual and are useful for…”
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CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice by Weber, Julia, Öllinger, Rupert, Friedrich, Mathias, Ehmer, Ursula, Barenboim, Maxim, Steiger, Katja, Heid, Irina, Mueller, Sebastian, Maresch, Roman, Engleitner, Thomas, Gross, Nina, Geumann, Ulf, Fu, Beiyuan, Segler, Angela, Yuan, Detian, Lange, Sebastian, Strong, Alexander, de la Rosa, Jorge, Esposito, Irene, Liu, Pentao, Cadiñanos, Juan, Vassiliou, George S., Schmid, Roland M., Schneider, Günter, Unger, Kristian, Yang, Fengtang, Braren, Rickmer, Heikenwälder, Mathias, Varela, Ignacio, Saur, Dieter, Bradley, Allan, Rad, Roland

“…Here, we show CRISPR/Cas9-based targeted somatic multiplexmutagenesis and its application for high-throughput analysis of gene function in mice. Using hepatic…”
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Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells by Tsang, Jason C H, Yu, Yong, Burke, Shannon, Buettner, Florian, Wang, Cui, Kolodziejczyk, Aleksandra A, Teichmann, Sarah A, Lu, Liming, Liu, Pentao

“…Hematopoietic stem cells (HSCs) are a rare cell type with the ability of long-term self-renewal and multipotency to reconstitute all blood lineages. HSCs are…”
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IL-6 trans-signaling promotes the expansion and anti-tumor activity of CAR T cells by Jiang, Zhiwu, Liao, Rui, Lv, Jiang, Li, Shanglin, Zheng, Diwei, Qin, Le, Wu, Di, Chen, Suimin, Long, Youguo, Wu, Qiting, Wang, Suna, Lin, Simiao, Huang, Xiaohan, Tang, Zhaoyang, Shi, Pengcheng, Zhou, Hongsheng, Liu, Qifa, Zhao, Ruocong, Li, Yangqiu, Jie, Yang, Wei, Wei, Lai, Peilong, Du, Xin, Cui, Shuzhong, Weinkove, Robert, Liu, Pentao, Pei, Duanqing, Yao, Yao, Li, Peng

“…Chimeric antigen receptor (CAR) T cell therapies lead to high clinical response rates in B cell malignancies, and are under investigation for treatment of…”
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PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice by Rad, Roland, Rad, Lena, Wang, Wei, Cadinanos, Juan, Vassiliou, George, Rice, Stephen, Campos, Lia S, Yusa, Kosuke, Banerjee, Ruby, Li, Meng Amy, de la Rosa, Jorge, Strong, Alexander, Lu, Dong, Ellis, Peter, Conte, Nathalie, Yang, Fang Tang, Liu, Pentao, Bradley, Allan

“…Transposons are mobile DNA segments that can disrupt gene function by inserting in or near genes. Here, we show that insertional mutagenesis by the PiggyBac…”
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Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c by Wiegreffe, Christoph, Simon, Ruth, Peschkes, Katharina, Kling, Carolin, Strehle, Michael, Cheng, Jin, Srivatsa, Swathi, Liu, Pentao, Jenkins, Nancy A., Copeland, Neal G., Tarabykin, Victor, Britsch, Stefan

“…During neocortical development, neurons undergo polarization, oriented migration, and layer-type-specific differentiation. The transcriptional programs…”
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Human and Pig Pluripotent Stem Cells: From Cellular Products to Organogenesis and Beyond by Xuan, Yiyi, Petersen, Björn, Liu, Pentao

“…Pluripotent stem cells (PSCs) are important for studying development and hold great promise in regenerative medicine due to their ability to differentiate into…”
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Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer by Lv, Jiang, Zhao, Ruocong, Wu, Di, Zheng, Diwei, Wu, Zhiping, Shi, Jingxuan, Wei, Xinru, Wu, Qiting, Long, Youguo, Lin, Simiao, Wang, Suna, Wang, Zhi, Li, Yang, Chen, Yantao, He, Qing, Chen, Suimin, Yao, Huihui, Liu, Zixia, Tang, Zhaoyang, Yao, Yao, Pei, Duanqing, Liu, Pentao, Zhang, Xuchao, Zhang, Zhenfeng, Cui, Shuzhong, Chen, Ren, Li, Peng

“…Gastric cancer (GC) is a common cancer in Asia and currently lacks a targeted therapy approach. Mesothelin (MSLN) has been reported to be expressed in GC…”
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Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis by Qin, Le, Cui, Yuanbin, Yuan, Tingjie, Chen, Dongmei, Zhao, Ruocong, Li, Shanglin, Jiang, Zhiwu, Wu, Qiting, Long, Youguo, Wang, Suna, Tang, Zhaoyang, Pan, Huixia, Li, Xiaoping, Wei, Wei, Yang, Jie, Luo, Xuequn, Zhang, Zhenfeng, Tang, Qiannan, Liu, Pentao, Weinkove, Robert, Yao, Yao, Qin, Dajiang, Thiery, Jean Paul, Li, Peng

“…Co-expression of chimeric switch receptors (CSRs) specific for PD-L1 improves the antitumor effects of chimeric antigen receptor (CAR) T cells. However, the…”
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