Search Results - "LIU, Jeff C"

Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem-Cell-Derived Venous Angioblasts by Gage, Blair K., Liu, Jeff C., Innes, Brendan T., MacParland, Sonya A., McGilvray, Ian D., Bader, Gary D., Keller, Gordon M.

“…Liver sinusoidal endothelial cells (LSECs) form a highly specialized microvasculature that plays a critical role in liver function and disease. To better…”
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RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation by Jones, Robert A, Robinson, Tyler J, Liu, Jeff C, Shrestha, Mariusz, Voisin, Veronique, Ju, YoungJun, Chung, Philip E D, Pellecchia, Giovanna, Fell, Victoria L, Bae, SooIn, Muthuswamy, Lakshmi, Datti, Alessandro, Egan, Sean E, Jiang, Zhe, Leone, Gustavo, Bader, Gary D, Schimmer, Aaron, Zacksenhaus, Eldad

“…Triple-negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which no specific treatment is currently available. Although the…”
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Single‐Cell, Single‐Nucleus, and Spatial RNA Sequencing of the Human Liver Identifies Cholangiocyte and Mesenchymal Heterogeneity by Andrews, Tallulah S., Atif, Jawairia, Liu, Jeff C., Perciani, Catia T., Ma, Xue‐Zhong, Thoeni, Cornelia, Slyper, Michal, Eraslan, Gökcen, Segerstolpe, Asa, Manuel, Justin, Chung, Sai, Winter, Erin, Cirlan, Iulia, Khuu, Nicholas, Fischer, Sandra, Rozenblatt‐Rosen, Orit, Regev, Aviv, McGilvray, Ian D., Bader, Gary D., MacParland, Sonya A.

“…The critical functions of the human liver are coordinated through the interactions of hepatic parenchymal and non‐parenchymal cells. Recent advances in…”
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Mitochondrial OXPHOS Induced by RB1 Deficiency in Breast Cancer: Implications for Anabolic Metabolism, Stemness, and Metastasis by Zacksenhaus, Eldad, Shrestha, Mariusz, Liu, Jeff C, Vorobieva, Ioulia, Chung, Philip E D, Ju, YoungJun, Nir, Uri, Jiang, Zhe

“…A switch from catabolic to anabolic metabolism, a major hallmark of cancer, enables rapid cell duplication, and is driven by multiple oncogenic alterations,…”
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RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs by Robinson, Tyler J W, Liu, Jeff C, Vizeacoumar, Frederick, Sun, Thomas, Maclean, Neil, Egan, Sean E, Schimmer, Aaron D, Datti, Alessandro, Zacksenhaus, Eldad

“…Triple negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which only chemotherapy and radiation therapy are currently available…”
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Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer by Liu, Jeff C., Granieri, Letizia, Shrestha, Mariusz, Wang, Dong-Yu, Vorobieva, Ioulia, Rubie, Elizabeth A., Jones, Rob, Ju, YoungJun, Pellecchia, Giovanna, Jiang, Zhe, Palmerini, Carlo A., Ben-David, Yaacov, Egan, Sean E., Woodgett, James R., Bader, Gary D., Datti, Alessandro, Zacksenhaus, Eldad

“…CDK4/6 inhibitors are effective against cancer cells expressing the tumor suppressor RB1, but not RB1-deficient cells, posing the challenge of how to target…”
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Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status by Jiang, Zhe, Deng, Tao, Jones, Robert, Li, Huiqin, Herschkowitz, Jason I, Liu, Jeff C, Weigman, Victor J, Tsao, Ming-Sound, Lane, Timothy F, Perou, Charles M, Zacksenhaus, Eldad

“…Breast cancer is a highly heterogeneous disease, with several different subtypes being characterized by distinct histology, gene expression patterns, and…”
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Distinct shared and compartment-enriched oncogenic networks drive primary versus metastatic breast cancer by Jiang, Zhe, Ju, YoungJun, Ali, Amjad, Chung, Philip E. D., Skowron, Patryk, Wang, Dong-Yu, Shrestha, Mariusz, Li, Huiqin, Liu, Jeff C., Vorobieva, Ioulia, Ghanbari-Azarnier, Ronak, Mwewa, Ethel, Koritzinsky, Marianne, Ben-David, Yaacov, Woodgett, James R., Perou, Charles M., Dupuy, Adam, Bader, Gary D., Egan, Sean E., Taylor, Michael D., Zacksenhaus, Eldad

“…Metastatic breast-cancer is a major cause of death in women worldwide, yet the relationship between oncogenic drivers that promote metastatic versus primary…”
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Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy by Chung, Philip E. D., Gendoo, Deena M. A., Ghanbari-Azarnier, Ronak, Liu, Jeff C., Jiang, Zhe, Tsui, Jennifer, Wang, Dong-Yu, Xiao, Xiao, Li, Bryan, Dubuc, Adrian, Shih, David, Remke, Marc, Ho, Ben, Garzia, Livia, Ben-David, Yaacov, Kang, Seok-Gu, Croul, Sidney, Haibe-Kains, Benjamin, Huang, Annie, Taylor, Michael D., Zacksenhaus, Eldad

“…Pineoblastoma is a rare pediatric cancer induced by germline mutations in the tumor suppressors RB1 or DICER1 . Presence of leptomeningeal metastases is…”
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Identification of tumorsphere- and tumor-initiating cells in HER2/Neu-induced mammary tumors by Liu, Jeff C, Deng, Tao, Lehal, Rajwinder S, Kim, Jinny, Zacksenhaus, Eldad

“…A variety of human malignancies, including breast cancer, are thought to be organized in a hierarchy, whereby a relatively minor population of tumor initiating…”
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Combined deletion of Pten and p53 in mammary epithelium accelerates triple‐negative breast cancer with dependency on eEF2K by Liu, Jeff C, Voisin, Veronique, Wang, Sharon, Wang, Dong‐Yu, Jones, Robert A, Datti, Alessandro, Uehling, David, Al‐awar, Rima, Egan, Sean E, Bader, Gary D, Tsao, Ming, Mak, Tak W, Zacksenhaus, Eldad

“…The tumor suppressors Pten and p53 are frequently lost in breast cancer, yet the consequences of their combined inactivation are poorly understood. Here, we…”
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Cooperation between Pik3ca and p53 Mutations in Mouse Mammary Tumor Formation by ADAMS, Jessica R, KELI XU, EGAN, Sean E, LIU, Jeff C, RUIZ AGAMEZ, Natalia M, LOCH, Amanda J, WONG, Ruth G, WEI WANG, WRIGHT, Katherine L, LANE, Timothy F, ZACKSENHAUS, Eldad

“…PIK3CA, which codes for the p110α catalytic subunit of phosphatidylinositol 3-kinase, is one of the most frequently mutated genes in human breast cancer. Here,…”
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Seventeen-gene signature from enriched Her2/Neu mammary tumor-initiating cells predicts clinical outcome for human HER2⁺:ERα⁻ breast cancer by Liu, Jeff C., Voisin, Veronique, Bader, Gary D., Deng, Tao, Pusztai, Lajos, Symmans, William Fraser, Esteva, Francisco J., Egan, Sean E., Zacksenhaus, Eldad

“…Human Epidermal Growth Factor Receptor 2-positive (HER2⁺) breast cancer (BC) is a highly aggressive disease commonly treated with chemotherapy and anti-HER2…”
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RB1 and p53 at the crossroad of EMT and triple-negative breast cancer by Jiang, Zhe, Jones, Robert, Liu, Jeff C., Deng, Tao, Robinson, Tyler, Chung, Philip E.D., Wang, Sharon, Herschkowitz, Jason I., Egan, Sean E., Perou, Charles M., Zacksenhaus, Eldad

“…Triple-negative breast cancer (TNBC) is a heterogeneous disease that includes Basal-like and Claudin-low tumors. The Claudin-low tumors are enriched for…”
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CDC25 as a common therapeutic target for triple-negative breast cancer - the challenges ahead by Zacksenhaus, Eldad, Liu, Jeff C., Granieri, Letizia, Vorobieva, Ioulia, Wang, Dong-Yu, Ghanbari-Azarnier, Ronak, Li, Huiqin, Ali, Amjad, Chung, Philip E.D., Ju, YoungJun, Jiang, Zhe, Shrestha, Mariusz

“…The dual phosphatase CDC25 has recently been identified as a target for diverse triple-negative breast cancers including RB1/PTEN/P53-deficient tumors…”
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Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations by MacParland, Sonya A., Liu, Jeff C., Ma, Xue-Zhong, Innes, Brendan T., Bartczak, Agata M., Gage, Blair K., Manuel, Justin, Khuu, Nicholas, Echeverri, Juan, Linares, Ivan, Gupta, Rahul, Cheng, Michael L., Liu, Lewis Y., Camat, Damra, Chung, Sai W., Seliga, Rebecca K., Shao, Zigong, Lee, Elizabeth, Ogawa, Shinichiro, Ogawa, Mina, Wilson, Michael D., Fish, Jason E., Selzner, Markus, Ghanekar, Anand, Grant, David, Greig, Paul, Sapisochin, Gonzalo, Selzner, Nazia, Winegarden, Neil, Adeyi, Oyedele, Keller, Gordon, Bader, Gary D., McGilvray, Ian D.

“…The liver is the largest solid organ in the body and is critical for metabolic and immune functions. However, little is known about the cells that make up the…”
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Preferential Killing of Breast Tumor Initiating Cells by N,N-Diethyl-2-[4-(Phenylmethyl)Phenoxy]Ethanamine/Tesmilifene by Deng, Tao, Liu, Jeff C, Pritchard, Kathleen I, Eisen, Andrea, Zacksenhaus, Eldad

“…Purpose: N,N -Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE; tesmilifene) is thought to potentiate the antineoplastic effect of cytotoxic drugs. In a…”
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Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer by Wang, Sharon, Liu, Jeff C, Kim, Danbi, Datti, Alessandro, Zacksenhaus, Eldad

“…Triple-negative breast cancer (TNBC), an aggressive disease comprising several subtypes including basal-like and claudin-low, involves frequent deletions or…”
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Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer by Langille, Ellen, Al-Zahrani, Khalid N, Ma, Zhibo, Liang, Minggao, Uuskula-Reimand, Liis, Espin, Roderic, Teng, Katie, Malik, Ahmad, Bergholtz, Helga, Ghamrasni, Samah El, Afiuni-Zadeh, Somaieh, Tsai, Ricky, Alvi, Sana, Elia, Andrew, Lü, YiQing, Oh, Robin H, Kozma, Katelyn J, Trcka, Daniel, Narimatsu, Masahiro, Liu, Jeff C, Nguyen, Thomas, Barutcu, Seda, Loganathan, Sampath K, Bremner, Rod, Bader, Gary D, Egan, Sean E, Cescon, David W, Sørlie, Therese, Wrana, Jeffrey L, Jackson, Hartland W, Wilson, Michael D, Witkiewicz, Agnieszka K, Knudsen, Erik S, Pujana, Miguel Angel, Wahl, Geoffrey M, Schramek, Daniel

“…Systematically investigating the scores of genes mutated in cancer and discerning disease drivers from inconsequential bystanders is a prerequisite for…”
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Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients by Wright, Katherine L, Adams, Jessica R, Liu, Jeff C, Loch, Amanda J, Wong, Ruth G, Jo, Christine E B, Beck, Lauren A, Santhanam, Divya R, Weiss, Laura, Mei, Xue, Lane, Timothy F, Koralov, Sergei B, Done, Susan J, Woodgett, James R, Zacksenhaus, Eldad, Hu, Pingzhao, Egan, Sean E

“…Breast cancer is associated with alterations in a number of growth factor and hormone-regulated signaling pathways. Mouse models of metastatic breast cancer…”
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